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Biomedical subjects

J F Navarro

Publications and source records attributed to J F Navarro.

At least 19 recordsLinked to original sources
PubMed2006

Effects of (+)SKF 10047, a sigma-1 selective agonist, on isolation-induced aggression in male mice.

sigma-1 Receptors have been identified in numerous brain regions, including areas such as hypothalamus and amygdala, which have long been linked to the regulation of aggression. However, there is no clear information with respect to the possible effects of sigma-1 ligands on aggressive behavior in laboratory animals. Consequently, the present study examined the effects of (+)SKF 10047 (0.5-6 mg/kg, i.p.), a sigma-1 prototypical agonist, on isolation-induced aggression in male mice, using an ethopharmacological approach. Individually housed mice were exposed to anosmic "standard opponents" 30 min after drug administration. Ten minutes of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped, and the accumulated time allocated by subjects to 10 broad behavioral categories was estimated using an ethologically based analysis. Results showed that (+)SKF 10047 (6 mg/kg) produced a significant reduction of offensive behaviors, without affecting immobility. Social investigation behaviors were also slightly increased after drug treatment (2-6 mg/kg). These results suggest a role for sigma-1 receptors in aggression modulation in mice.

Aggression↗
PubMed2004

Behavioral profile of SB 269970, a selective 5-HT(7) serotonin receptor antagonist, in social encounters between male mice.

The 5-HT(7) receptor is targeted by several antipsychotics, such as pimozide or clozapine, which have demonstrated antiaggressive properties in laboratory animal models. Likewise, 'in situ' hybridization and autoradiography studies have revealed moderate to high densities of 5-HT(7) receptors in limbic areas and hypothalamus, which have long been involved in the control of aggression. However, to date there is no evidence concerning the role of this receptor in the regulation of aggression. This study was designed to examine the effects of SB 269970 (1, 2, 4, 8, 16 and 32 mg/kg, i.p.), a selective 5-HT(7) receptor antagonist, on agonistic behavior elicited by isolation in mice. Individually housed mice were exposed to anosmic standard opponents 15 min after drug administration and encounters were videotaped and evaluated using an ethopharmacologically-based analysis. The results indicated that SB 269970 did not produce any significant behavioral changes, suggesting that 5-HT(7) receptors might not be involved in the modulation of aggression. Further studies with other selective ligands for these receptors are needed to confirm these findings.

Agonistic Behavior↗
PubMed2003

Effect of clinical and socio-economic factors on the rate of clustering of Mycobacterium tuberculosis clinical isolates in Elche (Spain).

We studied the association that exists between the epidemiological type clustering of isolates of Mycobacterium tuberculosis and certain clinical, epidemiological and socio-economic characteristics of tuberculosis patients in the Elche health district of Spain. A total of 144 patients diagnosed between 1993 and 1999 and whose isolates had been genotyped by IS6110-RFLP in an earlier study were included. Multivariate analysis showed that the independent variables associated with clustering of strain types were: age (1-25 years, OR 2.92, 95% CI 0.83 10.3), a high percentage of infection in the first circle of contacts (OR 2.89, 95% CI 0.96-8.68), urban dwelling (OR 2.12. 95% CI 0.73-6.2), use of bronchoscopy to obtain samples (OR 16.3, 95% CI 2.3-11.5) and working contact with many people (OR 2.81, 95% CI 0.94-8.3). These data contribute to a better understanding of the epidemiology of tuberculosis and improved systems of control.

Adolescent↗
PubMed2002

Molecular epidemiology of tuberculosis in Elche, Spain: a 7-year study.

The epidemiology of tuberculosis in Elche (Spain) was studied by restriction fragment-length polymorphism (RFLP) typing of clinical isolates of Mycobacterium tuberculosis over a 7-year period. A total of 165 isolates was typed and the clinico-epidemiological data of the patients were studied retrospectively. An overall cluster aggregation of 52.4% was found, rising to 71.43% in HIV-positive patients. There was greater aggregation in younger patients, but no statistically significant differences when other variables were analysed. The percentage of aggregation was higher than in other studies in Spain and this may be due to the longer time period of this study. The high percentage of aggregation in young patients and in thosewho were HIV-positive suggests increased recent transmission in both groups.

Adolescent↗
PubMed2001

MDMA ("ecstasy") exhibits an anxiogenic-like activity in social encounters between male mice.

Recent studies have suggested that 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"), a synthetic amphetamine derivative, might exhibit an anxiogenic-like activity in rodents. In this work, we examined the effects of MDMA (1, 8 and 15 mg kg(-1), i.p.) on social encounters between male mice using an ethopharmacological approach. Likewise, we compared the behavioural profile of MDMA with that induced by FG 7142 (15 mg kg(-1), i.p.), an anxiogenic benzodiazepine receptor ligand. Individually housed mice were exposed to anosmic standard opponents 30 min after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. MDMA (8 and 15 mg kg(-1)) produced a behavioural pattern characterized by a marked decrease of aggression (threat and attack) as well as social investigation, body care and digging behaviours, without affecting immobility. Moreover, avoidance/flee and defence/submission behaviours were significantly increased by the drug. A very similar behavioural profile was observed in FG 7142-treated animals. Overall, these findings might indicate that MDMA has anxiogenic-like properties in male mice.

Adrenergic Uptake Inhibitors↗
PubMed2001

Androgen therapy for anemia in elderly uremic patients.

Androgens were the mainstay of treatment of renal anemia prior to the introduction of recombinant human erythropoietin. With the introduction of this recombinant hormone, the protocols of treatment of anemia were completely modified, and the use of androgens was relegated to the background. However, several authors have continued showing interest in the use of androgenic steroids for the treatment of anemia. This review examines several aspects of aging on androgenic hormones and hematopoiesis, the effects of androgen administration on hematological parameters, the side effects of these compounds and the future of this treatment for anemia in renal patients.

Aged↗
PubMed2001

Attitudes toward animal research among psychology students in Spain.

Animal research plays a central role in psychology, and its use, prevalence and quality depends on the attitudes of students who enter psychology in Spain. Attitudes among psychology students about the use of laboratory animals are not known, so the aim of this work was to analyze the attitudes of Spanish psychology students toward animal research. An attitude questionnaire of 15 items was given to 661 undergraduate students of the School of Psychology at the University of Málaga, Spain. Several results were found: (a) 65.7% of the respondents strongly agreed or agreed with animal research. General support for animal research was significantly higher by men than by women. (b) Support for animal research was higher for senior students, suggesting that the psychology curriculum or self-selection to remain in the program might influence students' attitudes. (c) Attitudes toward animal research were similar among students independent of the type of animal being used for research in biological or psychological studies. (d) 58% considered that laboratory animals never or almost never are inappropriately handled. (c) 55.6% indicated that research in psychology on animals could be generalized to humans. Overall, these results suggest that among Spanish psychology students animals research is considered important for the advancement of the science. Likewise, a majority of students displayed positive attitudes toward animal research.

Adult↗