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Biomedical subjects

J F Murphy

Publications and source records attributed to J F Murphy.

At least 109 records · Page 6Linked to original sources
PubMed1984

Obstetric analgesia, anaesthesia and the Apgar score.

This study examines the changing pattern of maternal analgesia administration during the decade 1970-1979. In addition, the relationship between analgesia, anaesthesia and the infant's Apgar score was documented. Approximately 40000 deliveries to South Glamorgan residents were included in the study. Over the two quinquennia 1970-1974 and 1975-1979 the administration of epidural block increased from 5.6% to 17.5%. The Apgar score of babies in the epidural block group was significantly better in the latter period. Respiratory depression following Caesarean section remains a problem. The group delivered by elective Caesarean section contained a substantial proportion of infants with a low Apgar score; 30% had an Apgar score less than 8 and 10% had a score of less than 4. Likely causative factors include undue sensitivity of the infants' respiratory centre and aortocaval compression during surgery.

Analgesia↗
PubMed1984

Drugs and pregnancy.

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Abnormalities, Drug-Induced↗
PubMed1983

Antimicrobial properties of preterm breast milk cells.

The antimicrobial properties of preterm and term breast milk cells were compared. They were similar in cell numbers and in the capacity to phagocytose and kill staphylococci. Interferon production on endotoxin challenge appeared to be higher in preterm cells. The antibacterial activity of breast milk cells was retained after storage at 4 degrees C for 24-48 hours. Cell numbers were unaffected by passage through a standard oral paediatric feeding set.

Female↗
PubMed1983

Plasma 17-hydroxyprogesterone concentrations in ill newborn infants.

Plasma 17-hydroxyprogesterone concentrations were determined in 47 preterm and term infants who were ill from a variety of causes. The results were compared with those in 53 healthy term infants. Mean plasma 17-hydroxyprogesterone values were appreciably higher in ill term and healthy preterm infants compared with healthy term infants, but the highest values were found in ill preterm infants. None of the infants had adrenal disease but some very ill infants had plasma 17-hydroxyprogesterone values approaching those seen in untreated infants with congenital adrenal hyperplasia. Interpretation of the results of plasma steroid measurements in newborn infants must take account of gestational age and the presence of stress related illness.

17-alpha-Hydroxyprogesterone↗
PubMed1982

Ritodrine in the management of fetal distress.

The potential value of a bolus injection of ritodrine in the management of fetal distress was examined in 24 patients. Following the injection of ritodrine, uterine activity measured over a period of 14.7 +/- 6.3 (SD) min was reduced to 22 (+/- 12.4 SD)% of the pre-existing values. The cardiotocographic tracings showed a reversion to a normal or less ominous pattern in 14 of the 16 patients where this could be evaluated. The infants in the ritodrine group took less time to establish regular respirations. The perinatal neurobehaviour in the ritodrine and control groups did not differ. Two mothers who were given ritodrine and who received atropine premedication developed tachycardia and marked systolic hypertension. The administration of a bolus of ritodrine may have a place in the management of fetal distress when caesarean section is unavoidably delayed, but atropine premedication must be avoided as the combination can lead to potentially serious cardiovascular complications.

Adult↗
PubMed1981

Objective birth data and the prediction of child abuse.

The Cardiff Births Survey contains objective data that are easily collected and are reproducible between observers. We have compared survey records of 80 abused children with those of 80 control children. Of 44 factors that were examined 11 were appreciably more common in abused children. Such factors included the fact that the baby was preterm and had been admitted to a special care baby unit. Other factors were young maternal age, marital instability, low social class, and maternal smoking. 66% of abused children had at least 5 of these factors compared with only 16% of the control group.

Adolescent↗
PubMed1981

Pregnanediols and breast milk jaundice.

Samples of breast milk collected from mothers of infants with breast milk jaundice were analysed for 5 beta-pregnane-3 alpha, 20 beta-diol, and other pregnanediols using gas chromatography-high resolution mass spectrometry. None was detected in any of the specimens and therefore it is unlikely to be the inhibitory factor in bilirubin conjugation. The plasma osmolalities of the infants, which were determined at the onset of jaundice, were within normal limits.

Breast Feeding↗