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Biomedical subjects

J F Morgan

Publications and source records attributed to J F Morgan.

68 records · Page 4Linked to original sources
PubMed1966

Triethylene thiophosphoramide (thio-tepa) and pterygium.

A 1:2000 solution of a radiomimetic alkylating agent-triethylene thiophosphoramide (thio-tepa, Lederle Laboratories) with a proven inhibitory action on proliferating vascular endothelium, was used topically as an adjunct to pterygium surgery in an attempt to decrease the incidence of recurrence. A bare-sclera technique, with excision of the pterygium, was the surgical method used. Two drops of 1:2000 solution of thiotepa (15 mg in 30 cc of Ringer's solution) were applied every three hours while awake from the second postoperative day for six weeks. Twenty-six eyes received this treatment. There was one recurrence in the period of follow-up, which has been up to three years. Four fellow eyes, operated on at the same time with the same surgical technique, received no topical thio-tepa postoperatively. Two of these eyes developed a recurrence of the pterygium. No sequelae related to corneal damage, defective vision, or interference with wound healing were observed. No systemic effects were encountered. It is concluded that thio-tepa, used as described, is a safe, inexpensive and valuable aid in pterygium surgery.

Antineoplastic Agents, Alkylating↗
PubMedDate not supplied

Anorexia nervosa: changes in sexuality during weight restoration.

OBJECTIVE: We examined changes in sexual drive during weight restoration in patients with anorexia nervosa. METHODS: Eleven women with anorexia nervosa prospectively completed the Sexual Daydreaming Questionnaire (SDQ) and the Hospital Anxiety and Depression Scale (HADS) at five time points during inpatient treatment involving weight restoration. SDQ and HADS scores were recorded every 4 weeks until 8 weeks after subjects had reached the mean matched population weight (MMPW), which was monitored against body mass index (BMI). Histories were 'taken for purging, self-cutting, childhood sexual abuse, and number of sexual partners. Repeated-measures analysis of variance, regression analyses, and t tests were performed. RESULTS: BMI and sexual daydreaming were closely associated (p < .001). BMI and depression also achieved a statistically significant association (p = .046), with "caseness" for anxiety disorder throughout. Higher levels of sexual drive at MMPW seemed to be associated with purging, self-cutting, and childhood sexual abuse but not at low weight. Levels of sexual drive did not reflect previous sexual behavior. CONCLUSIONS: An increase in sexual drive accompanies weight restoration in patients with anorexia nervosa, which is consistent with psychological and physiological explanations of altered sexuality. Transient depression is also associated with weight gain. Changes in sexuality should be considered in both recovery and treatment failure.

Adult↗
PubMedDate not supplied

Psychogenic mania and bereavement.

Early notions of mania invoked a combination of psychogenic and organic factors, but psychogenic mania has not endured as a concept. We present a 37-year-old woman with an acute manic episode precipitated by the prolonged death of her husband from cancer. To our knowledge this is the first published account of 'maniacal grief' in the absence of pre-existing affective disorder, and with clear causal relations. Mania was clearly induced by the bereavement and we argue that the loss represented more than a non-specific life event. This case supports a re-examination of mania as potentially a 'reactive' or psychogenic phenomenon.

Acute Disease↗