Biomedical subjects
Publications and source records attributed to J F Molinari.
A bilateral compound hyperopic astigmat, with-the-rule, with incipient presbyopia and refractive amblyopia fitted with toric (custom) soft lenses in a monofit mode is described. Shortly after wearing the hydrogel toric lenses the patient developed a severe allergic reaction from a thimerosal based saline, which eventually resolved.
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This paper reviews two approved soft bifocal contact lenses for the U.S. market. The discussion centers around lens specifications, fitting philosophies, and clinical experiences with these lenses during clinical investigations.
This study was designed to determine the variability and validity of various hydrogel contact lens parameters. The front vertex power of the contact lens was measured with the Nikon Projection Vertometer. The contact lens overall diameter, base curve, and center thickness were measured (for 59 hydrogel contact lenses) using the Hydro-Vue Soft Lens Analyzer, model 1100. These hydrogel lenses were measured by three investigators in a masked comparison. It was demonstrated that the inter-investigator variability was minimal for the measured lens parameters. However, the measured parameters differed significantly from those stated by the manufacturer.
Clinicians use various topical agents for mydriasis in evaluation of the retina and its periphery. This paper shows the use of two mydriatic methods for this procedure--a combination of one drop 1% tropicamide (Mydriacyl) and the drop 1% hydroxyamphetamine hydrobromide (Paredrine) in comparison with the regimen of two drops 1% tropicamide (Mydriacyl) separated by five minutes. The degree of dilation, the resistance to intense comparable binocular indirect ophthalmoscope (BIO) illumination and the time recovery from these agents were evaluated in an optometric clinical setting. The same degree of mydriasis was demonstrated at the p greater than 0.01 level with these two regimens. The two regimens appear to be clinically similar for cycloplegic and mydriatic recovery time.
A case of transient ptosis due to GPC in a 14-year-old white female was presented. The hydrogel contact lenses were removed and after 3 days of cold compress management, the ptosis disappeared. After two months of spectacle wear the patient was refitted with hydrogel lenses made from a different material in a different design. In addition the solution regimen was changed to non-preserved saline and thermal disinfection. A review of the GPC literature and pathophysiological mechanism were presented.
Twelve human eyes had central corneal thickness measurements made by two investigators with the Haag-Streit 900 slitlamp and standard pachometer. Two endpoint methods were used for the final corneal thickness measurement setting in the microscope viewing eyepiece. The two methods used were (1) a touching of the epithelium/endothelium corneal split images and (2) an overlapping of the split images. Although final thickness measurements of the two investigators were similar, the results reveal a statistically significant difference for the two measurement methods.
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This study examines the validity of labeled parameters of aphakia-correcting soft contact lenses. The Nikon Projection Lensometer (NPL) and the Hydro-Vue Soft Lens Analyzer (HSLA) were used by two independent inspectors to measure 51 aphakia-correcting lenses. The contact lens power, diameter, and base curve were measured by each of the inspectors and compared to the labeled parameters. All parameter relations that were analyzed revealed that measurements made by the inspectors were not statistically different (p greater than 0.05) from each other and that their combined measurements were not statistically different (p greater than 0.05) from the labeled values.
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Giant papillary conjunctivitis (GPC) has recently been observed on the upper tarsal palpebral conjunctiva in soft contact lens patients. This article describes and discusses a group of patients who developed GPC. From these observations, a simple clinical procedure was devised to manage this problem while the patient maintained soft lens wearing time. The procedure included changes in the lens polymer, design, and cleaning regimen, which together enabled the affected patients to continue soft lens wear.
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Retinoscopy under cycloplegia with various agents can yield varied results. Additionally, cycloplegics and produce adverse local as well as central nervous system disturbances. A noncycloplegic near retinoscopy technique as promulgated by Mohindra is compared with cycloplegic retinoscopy on schoolchildren in early grades. Results obtained by a study utilizing the two techniques show that they yield similar objective measurements of refraction.