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Biomedical subjects

J F McManus

Publications and source records attributed to J F McManus.

At least 19 recordsLinked to original sources
PubMed1980

Dialysis enhances renal epithelial proliferations.

Study of 115 kidneys from 60 patients with chronic renal failure maintained by dialysis for two months to five years revealed an unexpected number and variety of epithelial proliferative processes, several types of which are hitherto unreported. Proliferative activity was defined either by the presence of epithelial structures in ectopic situations, continuity with existing structures being demonstrable by serial sections, or by mitotic figures, or by both. The tendency for renal carcinoma development may relate to these dialysis-related epithelial proliferations originating in both glomerular and tubular epithelia. Enhanced renal epithelial proliferative capacity in dialysis may be employable in the experimental study of renal regeneration and in the therapy of patients with preterminal renal disease.

Epithelium↗
PubMed1979

Studies of end-stage kidneys. III. Glycogen deposition in interstitial cells of the renal medulla.

Examination of kidneys of ten patients with uremia and severe hypertension treated by chronic intermittent hemodialysis revealed a deposition of glycogen within interstitial cells of the renal medulla. This is unlike any described renal distribution of glycogen. Electron microscopic studies performed in one case demonstrated monoparticulate glycogen both diffuse in the interstitial cell cytoplasm and locally aggregated beside lipid droplets. The findings provide evidence for a metabolic abnormality of renal medullary interstitial cells in patients who have protracted uremia.

Adult↗
PubMed1979

Studies on end-stage kidneys. V. Unusual epithelial activity or remarkable endothelial metaplasia. Findings in a dialyzed kidney.

Tubule-like cells were found lining an artery and several arterioles and within the capillaries of infarcted glomeruli in one block of kidney from one of 54 cases of end-stage/dialysis kidneys. Three other blocks showed tubule-like structures within infarcted glomeruli and adjacent arterioles. Squamous metaplasia of remaining tubule epithelium was found in sections from four blocks of the same kidney. In two of these blocks, infarcted glomeruli had capillaries which were occupied by squamous cells. These findings are discussed as examples of metaplasia of the endothelium or alternatively as epithelial growth and invasion. The use of special stains and multiple blocks for this study seem to have been justified. These changes offer further evidence that the end-stage kidney after dialysis has unique alterations.

Adult↗
PubMed1979

New therapies and new pathologies: end-stage--dialysis kidneys.

End-stage kidneys in patients who are receiving long-term intermittent treatment with hemodialysis are metabolic structures that participate in many body processes and that themselves develop and change despite severe excretory deficiencies. Nephron loss is severe. Other lesions in such kidneys include the following: smooth muscle nodules that arise in necrotic arteries and arterioles; embryonal hyperplasia of Bowman's capsular epithelium; remodeling of the arteries and veins; tubular atrophy; dilation and cyst formation (acquired cystic disease); arteriolar granular cell hyperplasia and hypertension; deposits of oxalate, calcium, and immune complexes; interstitial fibrosis with collagen and smooth muscle; mucoid change; and cellular infiltration. This list does not include all pathologic conditions found in the end-stage--dialysis kidney. The necessity of and the criteria for an experimental model of human long-term intermittent hemodialysis for end-stage renal disease, presently lacking, are indicated.

Acute Kidney Injury↗
PubMed1979

Induction of extraglomerular renal damage in experimental chronic serum sickness. I. Histologic and immunofluorescence findings.

Histologic and immunofluorescence studies were performed in nine rabbits after daily administration of human serum albumin at a fixed dosage for periods up to 26 weeks. All but one of the rabbits studied by immunofluorescence showed IgG, C3, and fibrinogen deposits in the renal glomeruli and in the tubules or peritubular tissues. In most cases, human serum albumin could also be identified in the deposits. In two rabbits killed at week 10, kidney pathology was minimal; in one of the rabbits killed in the early phases of the disease and in all rabbits killed after week 20, there were obvious pathologic changes affecting glomeruli, tubules, and/or interstitium. Tubulointerstitial changes were absent in only one of the rabbits killed at late stages of human serum albumin administration, in spite of evidence of tubular deposition of immune complexes. These observations suggest that tubulointerstitial damage is at least as frequent as glomerular damage during the induction of chronic serum sickness.

Animals↗
PubMed1978

Studies on "end-stage" kidneys. II. Embryonal hyperplasia of Bowman's capsular epithelium.

Clusters of deeply staining "embryonal-type" epithelial cells surround hyaline glomeruli in some patients with end-stage renal disease treated with dialysis. The kidneys of 40 patients, dialyzed for 2 months to 2 years, were studied with a variety of histologic and histochemical staining techniques. In 4 of these cases such "embryonal-type" cell clusters, arising from the parietal epithelium of Bowman's capsule and here termed "embryonal hyperplasia of Bowman's capsule epithelium" (EHBCE), are identified. In 6 additional cases there are similar cells in a tubular pattern, resembling the adenomatoid or pseudotubule structures of chronic, cresentic glomerulonephritis. The largest lesions are often found in groups within localized areas of cortex, giving their distribution a "field" effect. In such cases they have the appearance of new growths, suggesting the induction of a less differentiated cell type in these diseased adult tissues.

Adult↗
PubMedDate not supplied

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