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Biomedical subjects

J F Lucke

Publications and source records attributed to J F Lucke.

30 records · Page 2Linked to original sources

Collateral compensation of severe carotid stenosis.

In 516 patients who had endarterectomies for unilateral severe carotid stenoses, arteriography demonstrated no contralateral severe stenoses or occlusions. Pre and postoperative ocular pneumoplethysmography (OPG-Gee) measured simultaneous bilateral ophthalmic systolic pressures (OSP). Immediately after each OPG test a brachial systolic pressure (BSP) was measured with a stethoscope, cuff and manometer. Bilateral ophthalmobrachial systolic pressure (OBSP) indices were calculated from the three pressures measured with the combined testing. Analysis of these OBSP data indicates that the severe stenoses were relatively well compensated in 314 of the 516 patients (61%) whereas there was limited collateral compensation in the remaining 202 patients (39%). The data also suggest that the latter group incurs a greater element of compensatory central hypertension, which is reversed by carotid endarterectomy.

Blood Pressure↗

Reappraisal of ocular pneumoplethysmography after carotid endarterectomy.

An initial report documented a 3-year experience (1978 through 1980) with ocular pneumoplethysmography (OPG-Gee) done in the recovery room after carotid endarterectomy. The present report analyzes a similar 4-year experience (1981 through 1984) on 864 carotid endarterectomies performed by 20 surgeons in which the results of OPG tests done in the recovery room suggested carotid endarterectomy thromboses in 33 of the 864 patients (3.8%). All patients underwent immediate reoperation, and thromboses were confirmed in 26 of the 33 patients (79%). In the seven patients without thromboses, findings at reoperation accounted for the abnormal physiology in six of the seven patients. Overall, in 32 of the 33 patients (97%) the recovery room OPG tests accurately reflected a source of hemodynamic compromise. The application of the special OPG-Gee criteria in this report will minimize needless reoperation after carotid endarterectomy.

Anesthesia Recovery Period↗

Evidence for extending the circumplex model of personality trait language to self-reported moods.

We show that self-ratings by 141 undergraduates on 17 items form a circumplex that closely agrees with Conte and Plutchik's (1981) circumplex of personality traits. The order of items on a circumplex, generated by self-ratings following a here-and-now instruction set, scarcely differs from that of a circumplex representing the same ratings averaged over a 2-week period. The configuration becomes more elliptical as one moves from the state-like measures (here-and-now ratings) to pure trait measures (averages), but measurement bias is shown to be the most probable cause of the distortion. Allowing for the limitations of small samples of items and raters, the findings show that the circumplex model represents a valid theoretical construct and does not arise from measurement error or from an illusory implicit personality theory.

Adolescent↗

Measurement of the normal cervical cord by metrizamide myelography.

A modified C1-2 myelogram, using metrizamide (Amipaque), provides excellent visualization of the cervical spinal cord. The mean values of the sagittal diameter of the spinal cord are given in 100 selected cases. Comparison with these normal values is useful in the preliminary diagnosis of cervical cord atrophy versus syringohydromyelia.

Adolescent↗

Comparison of phenytoin and phenobarbital effects on far-field auditory and somatosensory evoked potential interpeak latencies.

Far-field somatosensory and auditory evoked potential (EP) interpeak latencies were measured in normal controls, epileptics not receiving medications, and epileptics receiving phenytoin, phenobarbital, or both. Phenytoin, but no phenobarbital, was associated with a prolongation of EP interpeak latencies at serum level concentrations over 20 micrograms/ml. Neither carbamazepine nor primidone in smaller series were associated with prolongation of EP interpeak latencies.

Epilepsy↗

Cerebellar atrophy in epilepsy and headache: lack of relationship to phenytoin.

CT scans of 70 patients with seizures and 48 patients with headaches were studied. Using accepted CT criteria for the diagnosis of cerebellar atrophy, the films were analyzed in a blind, unbiased fashion to evaluate possible relationship between cerebellar atrophy and phenytoin use or epilepsy itself. We found no evidence that either phenytoin or epilepsy caused cerebellar atrophy.

Adolescent↗

Estimation of nitrogen excretion based on abbreviated urinary collections in patients on continuous parenteral nutrition.

The physiologic response to stress can create a net loss of nitrogen, which is indicative of a catabolic state. Nitrogen balance has been demonstrated to be a useful clinical indicator of a patient's catabolic state and the effectiveness of parenteral nutrition, but requires an estimate of total urinary nitrogen excretion. The standard method for determining total urinary nitrogen excretion is 24-hour urinary urea nitrogen excretion. Unfortunately, the 24-hour urine collection is inconvenient, cumbersome, sometimes inaccurate, and induces a lag in response time to changes in therapy. Although shorter collection times have been proposed, the validity of shorter-timed determinations remains open to question. To evaluate the estimation of 24-hour urine urea excretion from shorter-timed determinations, the urinary urea nitrogen excretion of 4-, 8-, and 12-hour durations was regressed against the 24-hour collection in 56 critically ill adult patients. The 12-hour determination provided satisfactory estimates of the 24-hour nitrogen excretion, but the 4-hour and 8-hour determinations did not. Thus, two times the 12-hour urine urea nitrogen determination can be substituted for the 24-hour determination in calculating nitrogen balance. A 12-hour determination can provide a more rapid turnaround of biochemical analysis, allow more timely nutritional intervention, decrease nursing time, and reduce the frequency of inaccurate or lost specimens.

Humans↗