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Biomedical subjects

J F Larsen

Publications and source records attributed to J F Larsen.

At least 73 records · Page 4Linked to original sources
PubMed1986

Serum lipoprotein changes in climacteric women induced by sequential therapy with natural estrogens and medroxy-progesterone acetate or norgestrel.

Thirty perimenopausal women were randomized to sequential therapy with either estradiol-valerate and norgestrel (Cyclo-Progynon), or estradiol and medroxy-progesterone acetate (EM 627). Blood samples were drawn before treatment and in the third treatment cycle during estrogen and progestogen phases respectively. The clinical effects of the two treatments were without significant difference. Ovulation was not suppressed by the treatments, which induced similar increases in serum estradiol and estrone concentrations. The medium serum high density lipoprotein-(HDL)-cholesterol concentration expressed as a percentage of the pretreatment level decreased in the postmenopausal women treated with Cyclo-Progynon to 90% compared with 104% (p less than 0.01) in the EM 627 group. However, the concentrations expressed in mmol/l did not differ significantly, probably owing to non-significant differences in the pretreatment levels. Low density lipoprotein-(LDL)-cholesterol concentrations decreased by approximately 10% in the postmenopausal women during both treatments. Cyclic addition of medroxy-progesterone acetate to estrogen replacement therapy does not adversely affect the serum lipoprotein pattern, and may be preferable to norgestrel.

Adult↗
PubMed1986

Transcutaneous oxygen tension response to exercise in health and in occlusive arterial disease.

Transcutaneous oxygen tension (TcPO2) was measured on the foot at rest and during exercise in supine position in 21 clinically healthy controls and in 17 patients with intermittent claudication. All patients had ankle pressure greater than 50 mmHg and arteriographically proven peripheral vascular disease. Resting TcPO2 was significantly lower in the patient group than in the control group, though with considerable overlap between the groups. During exercise, however, TcPO2 showed highly significant decrease in the patient group. The median change following exercise in that group was -90% (range -54 to -100%) of the resting value. In the control group there was no significant fall in TcPO2 during 4 min exercise--median change -8% (range +30 to -34%). During exercise there was no overlap between the patient and the control group. Foot TcPO2 measurement during exercise in supine position is a simple, noninvasive and highly specific test for identifying patients with significant peripheral vascular disease.

Adult↗
PubMed1984

Preserved prolactin fluctuations and response to metoclopramide in ovulatory, infertile, hyperprolactinemic women.

The study included 18 infertile, hyperprolactinemic women with preserved menstrual cycles. Among 13 women with consistently elevated prolactin (PRL) levels, 6 had either anovulatory cycles or luteal insufficiency, whereas 7 had apparently normal ovulatory cycles. Comparisons of these two groups showed that basal levels were similar but the PRL response to metoclopramide (MTC) and the day-to-day fluctuations were significantly lower in the group with altered ovulatory function. In this group the PRL response to MTC was significantly greater than in control patients with hyperprolactinemic amenorrhea (n = 12), but lower than in normal women (n = 10). The PRL response to MTC in hyperprolactinemic women with normal ovulatory function did not differ significantly from that of normal women, irrespective of whether hyperprolactinemia was sustained (n = 7) or intermittent (n = 5). The study indicates that the degree of autonomy of PRL secretion reflected by both the fluctuations in basal levels and the response to a dopamine antagonist, may be used to evaluate whether or not slightly elevated PRL levels are of clinical significance in relation to fertility.

Adult↗
PubMed1983

Placenta flow index in posterior wall placentas measured with 99mtechnetium-labelled human serum albumin.

Measurement of the perfusion of posterior wall placentas with the isotope technique may pose a problem owing to attenuation of the gamma radiation. The present investigation compares the placenta flow index (PFI) in 34 pregnant women with anterior wall placenta and 13 with posterior wall placenta. We found no difference in the shortest skin-to-placenta distance on ultrasound scanning and no difference in PFI between the anterior and the posterior wall placentas.

Adult↗
PubMed1982

Suppressed prolactin but normal neurophysin levels in cigarette smoking breast-feeding women.

The hormonal responses to breast-feeding were studied during the first 3 post-partum weeks in ten women smoking more than fifteen cigarettes/day and in a control group. Basal PRL levels were significantly lower in smokers compared with non-smokers, but suckling induced acute increments in serum PRL and oxytocin-linked neurophysin, which were not influenced by smoking. The lactational pattern was normal, but smokers weaned their babies significantly earlier compared with non-smokers. Heavy cigarette smoking women have lower basal PRL levels and this may shorten the period of lactation.

Adult↗
PubMed1982

Perfusion of the intervillous space of the human placenta measured with 99mtechnetium labelled human serum albumin.

The perfusion of the intervillous space of the human placenta was investigated with 99Tc-Human Serum Albumin and external counting in 45 pregnant women between the 34th and 38th week of gestation. The pregnancy was normal in 34 women, while there was placental insufficiency in 11. Two variables were calculated from the placenta curve: the placenta flow index (PFI) and the mean transit time (t) for plasma through the intervillous space. From double determinations, the coefficient of variation for PFI was calculated to 1.6%. For t it was 20%. PFI was significantly higher in the controls than in the patients with placental dysfunction (P less than 0.05). There was a significant correlation between PFI and t (rs = - 0.36, P less than 0.05). The plasma oestriol level and the PFI correlated significantly, whereas the correlation between t and the plasma oestriol level was not significant. The placenta flow index can be used to measure the physiological effect of a pharmacological treatment, bedrest or other treatments.

Chorionic Villi↗