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Biomedical subjects

J F Hirsch

Publications and source records attributed to J F Hirsch.

At least 109 records · Page 6Linked to original sources
PubMed1976

[New data on the disease induced by laxatives].

The authors report 5 personal case and recall the physiopathological mechanisms of metabolic disorders observed during the abuse of laxatives. They emphasize the fact that electrolyte losses were not only fecal, but also aggravated by frequent use of diuretics or dietary restriction. One may oppose the constant, very marked fall in body potassium to the variation in sodium content of the organism. Oedema formed part of the clinical picture. The withdrawal of drastic laxatives and diuretics, led to rapid recovery of all the symptoms.

Adult↗
PubMed1976

Temporo-spatial propagation of epileptoform after-discharges in the isolated cat suprasylvian gyrus.

1. Epileptiform after-discharges (EADSs) induced by electrical stimulation of the isolated suprasylvian gyrus were studied in cats with chronically implanted electrodes. 2. In a given region and at a certain time after stimulation, the following events took place: (a) a slow radial spread of the zone of maximal depolarization, from the cortical surface downward, as evidenced by a laminar study; (b) a massive cellular discharge preceded by a period during which few unit activities were detected, followed by bursts of spike activity timed with the surface-positive waves of the ECoG; (c) a surface-negative DC shift with maximal amplitude around 1000 mum below the surface; (d) the occurrence of a synchronizing focus from which the paraoxysmal waves propagated to the whole gyrus. 3. All these phenomena spread across the surface of the gyrus with a velocity (7-20 mm/min) similar to that of focal seizures in man.

Action Potentials↗
PubMed1976

Intracranial pressure and rapid eye movement sleep in hydrocephalus.

Intracranial pressure (ICP) was monitored for 24 h in 30 hydrocephalic patients (21 infants, 9 children) representing borderline cases. The need for surgery was uncertain because their hydrocephalus seemed to be more or less arrested. In 13 cases an electroencephalogram, an electro-oculogram, an electromyogram and an actogram were simultaneously recorded. During sleep related to a period of rapid eye movement (REM) fairly regular steep-rising waves of raised ICP recurred every 50-75 min, decreasing slowly to previous levels in 25-40 min. No concomitant clinical symptoms were exhibited. The cerebral pulse wave amplitude increase during REM sleep, but might vary during one period of REM sleep. The relationship between these raised ICP waves and an increase in cerebral blood flow occurring during REM sleep is studied.

Child, Preschool↗
PubMed1975

[Role of the ventriculocisternostomy in the treatment of non-communicating hydrocephalus].

44 ventriculo-cisternostomies were carried out on infants and children who manifested non communicating hydrocephalus. They were performed through perforation of the floor of the 3th ventricle with the aid of a leukotomy trochar which was introduced through a frontal ventriculography burr hole, and then guided under X ray control. The study of this group showed that the operation is benign, although the mortality is not null, and is effective except in the case where non communicating hydrocephalus develops after meningeal haemorrhage of meningitis. The late results seem good, but the time lapse is too short for a final conclusion. The preoperative radio-isotopic cisternography does not unable prediction of the cases which will be failures; it does however sometimes make it possible to foresee those which will be successful. The post-operative radio-isotopic cisternography is useful in checking on the permeability of the shunt.

Cerebral Ventricles↗
PubMed1975

[Neurosurgery under strict asepsis. Effect of the surgical isolator on the level of infections after valve shunts for hydrocephalus].

The authors report on two groups of 75 shunts for hydrocephalus. Each group includes both cases in which the shunt was implanted for the first time and cases in which the repair of a former shunt was necessary either for mechanical or infectious complications. The operations within the first group were performed with traditional techniques; those of the second group were carried out during the same period of time and by the same team, but with the use of a surgical isolator. The overall rate of early infections was greatly reduced in the second group. Careful analysis of the infections which still occured with the surgical isolator indicated that they were related to the reappearance of a preoperative infection or to secondary contamination through post-operative cutaneous complication. In this second group using the surgical isolator, no contamination occured during the operation itself.

Antisepsis↗