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Biomedical subjects

J F Hansen

Publications and source records attributed to J F Hansen.

At least 127 records · Page 7Linked to original sources
PubMed1980

A new high quality albumin for therapeutic use.

A method of large scale plasma fractionation where PEG precipitation combined with absorption is described. This method permits isolation of most globulins under mild conditions. The final purification of the albumin is achieved by heat treatment at 60 degrees C pH 4.8. The quality of albumin preparations for therapeutic use is discussed from two points of view, purity and nativity. The main problem of purity is the content of high molecular weight aggregates formed by the pasteurization (60 degrees C, 10 h.). The aggregates give a risk for immunological reactions. The nativity of albumin is correlated to the contents of oxidized albumin, and to the metabolism in man. In all the methods discussed, considerable differences are found between albumin preparations produced by different methods.

Hot Temperature↗
PubMed1980

Progress in chemical and in vivo characterization of albumin preparations.

In plasma fractionation industry different methods are used for producing albumin for therapeutic use. We wanted to investigate whether the different ways of fractionating plasma have an effect on the nativity of the albumin molecules. Isoelectric focusing in 6M urea has shown the presence of variable amounts of oxidized albumin in different preparations. The presence of oxidized forms indicates that an initial denaturation has taken place. To evaluate if the alteration in the albumin molecules has any effects in vivo, metabolic studies in rabbits and humans with radioiodinated albumin were undertaken. Our preliminary results show a correlation between the in vivo metabolic studies and the amount of oxidized albumin.

Albumins↗
PubMed1979

Q waves and coronary artery disease.

In a consecutive series of 234 patients admitted for selective coronary arteriography, 78 had pathological Q waves. In 32 of these 78 patients, ECG showed left ventricular hypertrophy, QRS duration of greater than or equal to 0.12 sec, incomplete left bundle branch block, or left axis deviation. Fourteen (44%) of these 32 patients had coronary artery disease (CAD), while 40 (87%) of the remaining 46 patients without these ECG changes had CAD (p less than 0.0005). Among the 46 patients, 34 of 35 with angina pectoris had CAD compared to 6 of 11 without angina pectoris (p less than 0.01). Our study thus shows that Q waves may be reliable predictors of CAD especially in patients with angina pectoris.

Angina Pectoris↗
PubMed1979

DC-conversion of atrial fibrillation after mitral valve operation. An analysis of the long-term results.

In a prospective study comprising 43 patients with atrial fibrillation after mitral valve surgery, an evaluation was made of the prognostic significance of clinical, radiological, haemodynamic and operative factors for the maintenance of sinus rhythm after DC-conversion. Atrial fibrillation with a duration of less than 12 months proved to be the only single factor of significance for sustained sinus rhythm after 12 months and it is suggested as a simple clinical criterion for selection of patients for DC-conversion after mitral valve operation.

Adult↗
PubMed1978

The influence of acute blood volume changes on plasma renin activity in man.

The effect of an acute 10% blood volume reduction on plasma renin activity (PRA) was examined in seven patients with minor heart diseases during haemodynamic investigation and in five healthy subjects after 3 days furosemide administration. PRA was not significantly changed. Blood pressure remained constant, atrial pressures decreased. The effect on PRA of an acute 10% blood volume expansion with albumin infusion was studied in thirteen patients with liver or heart diseases. A slight reduction of PRA after albumin did not exceed the expected decrease due to plasma dilution. Blood pressure was unchanged, atrial pressures increased. Renal blood flow increased after albumin in all of the five patients investigated. The effect of PRA of an acute 10% blood volume expansion with whole blood flow increased after albumin in all of the five patients investigated. The effect on PRA of an acute 10% blood volume expansion with whole blood was then investigated in five healthy subjects, pretreated with furosemide for 3 days. A significant decrease in PRA was found. Blood pressure remained constant. It is concluded that an acute blood loss of 10% and an acute blood volume expansion of 10% with albumin have little influence on PRA in supine man, whereas an acute blood volume expansion of 10% with whole blood induces a significant PRA suppression.

Adult↗
PubMed1978

Determinants of coronary sinus noradrenaline in patients with ischaemic heart disease: coronary sinus catecholamine concentration in relation to arterial catecholamine concentration, pulmonary artery oxygen saturation and left ventricular end-diastolic pressure.

Arterial and coronary sinus noradrenaline (NA) and adrenaline (A) concentrations, cardiac output, pulmonary artery oxygen saturation (PAO2), coronary sinus oxygen saturation, left ventricular end-diastolic pressure (LVEDP), and arterial pressure were examined in 21 patients with ischaemic heart disease at rest and during exercise before and after intravenous propranolol. The heart had a net uptake of A and a net release of NA. It can be estimated that at least 50% of NA in the coronary sinus derived from the heart. NA in the coronary sinus and in the arterial blood originated therefore, at least partially, in different tissues. The NA concentration showed close correlation with PAO2, but not with cardiac index or arterial blood pressure. Multiple regression analysis also revealed a relationship between LVEDP and arterial and coronary sinus NA independent of PAO2. A very close correlation between arterial and coronary sinus NA (r = 0.93, P less than 0.001) indicates that they are largely controlled by the same factors.

Adult↗
PubMed1978

Coronary arteriographic findings in patients with previous acute myocardial infarction.

In a consecutive series of 234 patients admitted for selective coronary arteriography, 49 had had definite acute myocardial infarction (AMI) three months to ten years previously. More than 75% stenosis in at least one of the major coronary arteries was found in 80% of the patients. Two and three-vessel disease was demonstrated in 31% of the patients, which differs significantly from the 75-80% reported in autopsy studies in patients dying from AMI. At ventriculography all 22 patients with pathological Q waves had dyssynergy of the left ventricle.

Acute Disease↗
PubMed1978

Enhanced sympathetic nervous activity after intravenous propranolol in ischaemic heart disease: plasma noradrenaline splanchnic blood flow and mixed venous oxygen saturation at rest and during exercise.

To study the mechanisms by which acute beta-adrenergic blockade may change the activity of the sympathetic nervous system we have measured haemodynamic responses including splanchnic blood flow in twenty-three patients with ischaemic heart disease at rest and during supine exercise before and after i.v. injection of 0.039 mmol (10 mg) dl-propranolol. After propranolol both at rest and on exercise blood pressure, cardiac output and heart rate decreased, while splanchnic vascular resistance increased; mixed venous oxygen saturation decreased whilst arterial oxygen saturation and oxygen uptake were unchanged. Plasma noradrenaline increased after propranolol, values correlating with mixed venous oxygen saturation and splanchnic vascular resistance, both at rest and during exercise before and after propranolol, only at rest was there any correlation with arterial blood pressure. The increase in sympathetic nervous activity after propranolol may be due to a reduction in cardiac output and thereby alteration of the metabolic state (oxygen or related factors) in tissues. Afferent neural signals from the tissues may play a significant role in the regulation of sympathetic nervous activity.

Abdomen↗
PubMed1978

Reduced myocardial blood flow in acute and chronic digitalization.

The myocardial blood flow was measured by the 133Xenon disappearance curve from the left ventricular wall following an injection of 133Xenon in the left coronary artery in 8 dogs without digoxin pretreatment and in 8 chronically digitalized dogs. The myocardial blood flow was significantly less (30%) in the digitalized dogs than in the dogs without pretreatment. In the digitalized dogs as well as in those without pretreatment an intravenous injection of digoxin resulted in a further significant decrease of the myocardial blood flow of about 20% and a significant increase of the coronary vascular resistance. The reduced myocardial blood flow both during acute and chronic digitalization is beleived to be of clinical importance.

Animals↗
PubMed1978

Closed mitral valvulotomy after the age of fifty.

This retrospective study is based upon a consecutive series of 90 patients with mitral stenosis who had their first closed mitral valvulotomy after the age of fifty. All patients were operated on during the period 1959--70 and were followed-up for at least 5 years until July 1, 1976. Calculated survival curves were compared with those of a group of 68 patients over fifty whose mitral stenosis was medically treated. The surgical mortality was 7.8%, largely due to the high mortality among patients in functional class IV. The late mortality rate after valvulotomy was significantly higher than in a matched population of the same age and sex, but significantly lower than in the medically treated patients. According to functional classification, the patients had improved markedly at the time of follow-up. High incidences of atrial fibrillation and late thromboembolic complications were noted. This study supports the view that closed mitral valvulotomy can be performed safely in patients over fifty with mitral stenosis without significant mitral regurgitation and heavy clacifications in functional classes II and III.

Age Factors↗