An insulin-inhibitory factor of human blood.
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Biomedical subjects
Publications and source records attributed to J F Green.
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1. The effects of isoprenaline on the pressure-flow relationships in the peripheral circulation were studied in five anaesthetized dogs during right heart bypass procedures. 2. Isoprenaline (1 mug/kg per min) produced a significant drop in arterial pressure and arterial resistance. 3. There was a significant decrease in the resistance to venous return which resulted in a significant increase in venous return. 4. The findings suggest that the increase in cardiac output produced by isoprenaline results in large part from dilatation of venous resistance vessels.
1. The influence of practolol (a proposed beta1-adrenoreceptor antagonist) upon the pressure-flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by-pass procedures. 2. Practool (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective beta-adrenoreceptor antagonist.
Chronic synovitis of the elbow in rheumatoid arthritics that has not responded to four to six months of optimal nonoperative management should be treated by synovectomy even in the absence of significant intra-articular X-ray changes. When intra-articular damage is significant, an arthroplasty will not only relieve the pain, but may also provide a satisfactory range of motion. It is necessary to consider all the possible complications and the fact that technically, total elbow arthroplasty is a difficult operation to perform. Because of the potential for loosening, one might consider using an unconstrained device in the patient with adequate bone structure, reserving the semiconstrained devices for elbows with disintegrated bone tissues. The constrained prostheses should be used only for the most severely disorganized and unstable elbows.