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Biomedical subjects

J F Foncin

Publications and source records attributed to J F Foncin.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Estrogen and progestin receptors in meningiomas: a study in 22 cases (author's transl)].

The authors have searched for oestrogene (RE) and progesterone (RP) receptors in 22 cases of meningiomas. Hormone receptors were determined on the cytosol and nuclear fractions of tumor tissues, using synthetic oestrogen R 2858 and progestin R 5020 in conditions where exchange was nearly achieved. The receptors were considered as present for values equal or higher than 100 femtomoles per gram of tumour tissue (fmol/gT). For the 22 studied cases the RE were present in 13 cases (59 p. 100) with values between 100 and 500 fmol/gT in 9 cases and higher than 500 fmol/gT in 4 cases. The RP were present in all cases (100 p. 100), with values between 100 and 500 fmol/gT in one case, between 500 et 5 000 fmol/gT in 13 cases and higher than 5 000 fmol/gT in 8 cases. The results were compared with neuropathologic data obtained by light microscopy. The clinical and biological significance of results are discussed.

Adult↗
PubMed1978

[Myelinopathy due to carbon monoxyde poisoning. A study in ultrastructural neuropathology (author's transl)].

A 24-year-old woman was found comatose after 2 days of cephalalgia and vomiting. An immediate diagnosis of carbon monoxyde poisoning was disclaimed when blood carbon monoxyde was found to be 1.75 ml/100. A diagnosis of acute intracranial hypertension led to trephination with ventricular punction and brain biopsy on the third day. The patient died on the eleventh day. Ultrastructural study of biopsy tissue showed nearly normal cortex, and injured white matter, with disrupted or destroyed myelin and pycnotic oligodendroglia in contrast with nearly normal axons, astrocytes, and capillaries. Autopsy showed a typical semioval center myelinopathy. After discussion of the histotoxic, vascular, and edema theories for myelinopathy pathogenesis, primary oligodendrogial lesion is considered, and correlated with the diphasic evolution often observed in the course of carbon monoxyde myelinopathy.

Adult↗
PubMed1978

The brain surrounding malignant gliomas: an ultrastructural study.

Brain samples were taken in macroscopically oedematous zones during 21 operations for malignant glioma, and studied with the electron microscope. Oedema was found in 17 cases, mostly as serous extracellular fluid. Vascular changes in the oedema region are mostly as serous extracellular fluid. Vascular changes in the oedema region are mostly secondary to oedema: the origin of oedema fluid ought to be found in the tumour proper. Cellular reaction is slight; neuronal lesions may be ascribed mostly to a perturbation of axonal flow. Oedema round malignant gliomas and oedema round other malignant or benign tumours are morphologically distinct.

Astrocytes↗
PubMed1977

[Curable ECHO 5 virus encephalitis. Clinical, electroencephalographic, virologic and ultrastructural study].

A 10 1/2 years old boy fell brutally ill with a fit followed by confusion, and then by deep coma, with 40 degrees C fever and morbilliform rash. Consciousnesse came back within ten days, with transient Parkinson-like tremor. Myoclonus persisted for about six months. Complete recovery was followed up for six years. A diagnosis of encephalitis was considered on early EEG evidence (stereotyped repetitive sharp wave bursts) and was confirmed by isolation of ECHO 5 virus from brain specimen, and ultrastructural observation of characteristic cytopathic effect (disappearance of organelles, proliferation of smooth membranes) and of probable viral particules in astrocytes, without any inflammatory process.

Cerebral Cortex↗
PubMed1976

[Cerebral cortex in normal pressure hydrocephalus: an electron microscopy study (author's transl)].

A cortical biopsy was taken at the time when ventricular pressure was measured, or a ventriculo-atrial shunt placed, in 11 patients with Normal Pressure Hydrocephalus (N.P.H.), and was studied with the electron microscope. In 9 cases, a rather typical electron microscopic picture with marked increase of extracellular space in an otherwise normal cortical neuropil was observed. 2 patients did not exhibit this pattern and, coincendentally, did not benefit from the placing of the shunt. As a control, about 600 cortical biopsies that had been taken for other reasons were reviewed. In the group, there were only 3 cortices that had a pattern of increased extracellular space similar to the described in N.P.H. On review of the clinico-pathologic data of these cases, it was felt that all 3 probably represented cases of normal pressure hydrocephalus. It is concluded that the ultrastructure of the cerebral cortex is of at least nosological interest in the study of N.P.H.

Cerebral Cortex↗
PubMed1975

[Human Scarpa ganglion cell sheath].

The ganglion vestibulare (Scarpa) has been studied with the electron microscope on thirteen operative specimens (neurectomy for Meniere's vertigo) and two random autopsy specimens. Neuroganglionar cell bodies are enclosed in a Schwann sheath, without any myelin. This observation is at variance with previous descriptions in various vertebrate forms.

Humans↗
PubMed1975

Primary and borderline brain lymphosarcoma: a neuropathological review of nine cases.

Brain lymphosarcoma may be divided into the circumscribed forms, surrounded by marked oedema with fibrin, and the diffuse or infiltrating forms. Cytology of the former is more uniformly lymphocytic, its clinical course is more rapidly fatal. Anatomically primary diffuse lymphosarcoma of the brain may be secondary to 'cured' systemic lymphoma.

Adult↗
PubMed1975

[The neurosurgical forms of Hurst's acute hemorrhagic leukoencephalitis].

Within the group of acute encephalitis, H.A.H.L. is individualized mostly by its post mortem pathology. But several cases of recovery were recently published, the diagnostic being based on biopsy material. In 4 of our 8 cases, a comparison between the biopsy and post mortem examinations was possible : in/the diagnostic of H.A.H.L. was unequivocally confirmed, in 2 H.A.H.L. is nearly certain, in 1 it is doubtful. These considerations do not contradict the necessity of an emergency brain decompression in many instances of acute encephalitic states.

Acute Disease↗