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Biomedical subjects

J F Fitzgerald

Publications and source records attributed to J F Fitzgerald.

At least 127 records · Page 7Linked to original sources
PubMed1978

A suggested classification and reappraisal of mortality statistics for ruptured atherosclerotic infrarenal aortic aneurysms.

A retrospective review of 80 ruptured infrarenal abdominal aortic aneurysms with classification of the patients into clinical groups based upon the findings at laparotomy was undertaken. Patients with small hematomas confined to the area of rupture were uniformly salvaged. Those with free intraperitoneal blood almost invariably died. Intermediate groups had mortalities od 37.5 and 62.5 per cent. It is concluded that operative mortality is related to the clinical group to which the patient belongs. Attention must be focused upon the potentially salvageable intermediate groups, with regard to early laparotomy and prompt, effective proximal and distal control of the aorta before entering the retroperitoneal hematoma. Major improvements in survival have occurred with smaller ruptures but little has been achieved with larger ruptures during the past 25 years.

Aged↗
PubMed1977

Cosmetic excision of an isolated extracranial arteriovenous malformation using Gelfoam embolization.

Surgical excision of extracranial arteriovenous malformations may be indicated for cosmetic or urgent medical reasons, such as haemorrhage or high output cardiac failure. However, serious haemorrhage, incomplete removal and poor cosmetic results are well-known complications encountered after this operation. Preoperative embolization under angiographic control is recommended to reduce the incidence of these problems.

Arteriovenous Malformations↗
PubMed1977

Effect of maternal protein deprivation on the development of neonatal intestinal function in rats.

The developmental pattern of in vitro intracellular accumulation (IA) was studied in the small intestine of the offspring of females fed a 27% protein diet (normal) (NPD animals) and the offspring of females fed an 8% protein diet (low) (LPD animals). At 2 days of age, the IA of L-leucine (Leu) and D-galactose (Gal) was significantly reduced in the intestines of the LPD animals as compared to the NPD animals at initial velocities (75% and 81%) and under steady state conditions (82% and 84%). The IA of both compounds in the intestines of the LPD animals increased relative to the NPD animals until at weaning the IA of Leu and Gal under steady state conditions was significantly greater in the LPD animals (139% and 133%). After weaning, the IA of Leu was statistically increased (137%) and the IA of Gal was the same in the LPD animals as compared to the NPD animals at initial velocities. The variations in the developmental patterns of the IA of Leu and Gal in the intestines of LPD animals as compared to NPD animals appear to be related to animal age, which may reflect an improved caloric intake at weaning.

Animals↗
PubMed1977

Colonization of the gastrointestinal tract.

The alimentary tract is sterile at birth but colonic colonization is relatively complete by the end of the first week of life. The upper alimentary tract is colonized by microorganisms normally inhabiting the oral cavity. The colon on the other hand appears to be colonized by microorganisms originating in the maternallower alimentary tract. The colonic flora of infants is affected by diet (breast or formula feedings). The presence of a "fecal-type" flora in the proximal small bowel should be considered abnormal. Most authors agree on the need to define the role of the microflora in health and disease.

Adult↗
PubMed1976

Unusual manifestations of Henoch-Schönlein syndrome.

Henoch-Schönlein syndrome represents a diagnostic challenge when the abdominal and/or joint manifestations precede the cutaneous lesions. Laparotomy is often performed unnecessarily. We describe a patient whose abdominal symptoms antedated the appearance of cutaneous lesions by three months. Gastrointestinal blood loss, thrombocytosis, hypoproteinemia, and the roentgenographic appearance of the small intestine suggested the correct diagnosis. His course was further complicated by hypertension associated with elevated plasma renin levels without evidence of nephritis. Joint manifestations were mild and transient as were testicular pain and swelling.

Child↗
PubMed1976

Portal hypertension in infants and children with histiocytosis X.

Histiocytosis X describes a disease characterized by histiocytic infiltration of the reticuloendothelial system, skin, bones, and pituitary gland. The disseminated form frequently occurs in infants and children. Chemotherapy has significantly improved the prognosis in this disorder. Sixty-three per cent of survivors, however, have some residual disability related to fibrosis of tissues previously infiltrated by histiocytes. In instances of liver involvement, healing by fibrosis may result in cirrhosis with portal hypertension and bleeding esophageal varices. Clinical findings include hepatosplenomegaly, jaundice, ascites, hypoalbuminemia, prolonged prothrombin time, and Bromsulphalein retention. Histologic examination of the liver shows a characteristic dense "macronodular" periportal cirrhotic pattern. Three children with portal hypertension and bleeding varices due to healed histiocytosis X were sucessfully managed by portosystemic shunt procedures. Portacaval, mesocaval, and central splenorenal shunts were equally effective in relieving poral hypertension. These children had neither recurrence of bleeding nor evidence of encephalopathy. Two children remain well whereas in one patient a primary hepatoma developed fourteen years posthung and he died of pulmonary metastases. Portosystemic shunt procedures effectively relieve the threat of potentially fatal variceal hemorrhage and improve the opportunity for long-term survival in children with cirrhosis and portal hypertension due to healed histiocytosis X.

Age Factors↗
PubMed1975

Effect of maternal protein deprivation on in vitro neonatal intestinal function in rats.

Pregnant rats were fed a 27% (normal) protein diet or an 8% (low) protein diet. The in vitro absorptive capacity of the small intestine of the 2-day-old offspring of these animals was studied. The intracellular accumulations of a prototype amino acid (L-leucine) and sugar (D-galactose) were measured at initial velocity. The offspring of females fed the 8% (low) protein diet demonstrated a 32% decrease in the intracellular accumulation of leucine and a 19% decrease in the intracellular accumulation of galactose. The results are suggestive of a decrease in available transport sites in the offspring of protein-deprived females.

Animals↗
PubMed1975

False aneurysm as a late complication of anterior dislocation of the shoulder.

A review of the leterature since 1947 fails to show a report of a false aneurysm with uncomplicated anterior shoulder dislocation. If this potential late complication is to be diagnosed and treated before the patient is released from followup medical care, careful attention must be given to alterations in the radial pulse prior to reduction. Patients who demonstrate an abnormal radial pulse which reverts to normal following reduction should have an angiogram. Pathological findings to the underlying axillary artery must be repaired promptly. Anterior dislocations of the shoulder account for approximately 50% of all dislocations and tend to be most frequent in healthy males. Late vascular complications associated with this injury are infrequent and can therefore be easily overlooked as illustrated in this report.

Aneurysm↗
PubMed1974

Infant feeding.

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Birth Weight↗
PubMed1974

Infant feeding.

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Animals↗