Nucleotide and polynucleotide synthesis in Trypanosoma cruzi. VI. In vitro effect of analogs of the aminonucleoside of stylomycin.
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Biomedical subjects
Publications and source records attributed to J F FERNANDES.
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In rats and guinea-pigs both mast cell damage and histamine release in anaphylaxis were inhibited by pyridine, nicotinamide, diethylnicotinamide, nicotinic acid, isonicotinic acid and isonicotinic acid hydrazide, which are known to be inhibitors of diphosphopyridine nucleotidases. On the other hand these compounds potentiated histamine release and mast cell damage by compound 48/80 in guinea-pigs although inhibiting the same phenomena in rats. The relationship of these findings with the mechanism of histamine liberation in anaphylaxis is discussed.
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