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Biomedical subjects

J F Davidson

Publications and source records attributed to J F Davidson.

At least 91 records · Page 5Linked to original sources
PubMed1974

Medicines evaluation and monitoring group: central nervous system effects of pentazocine.

Hospital-based drug monitoring facilities have been used to investigate the frequency of perceptual disturbances in inpatients receiving pentazocine and the occurrence of dependence upon this drug after discharge from hospital. A pilot study was carried out in which seven out of 70 hospital inpatients receiving pentazocine reported such episodes, while in a prospective study, 9 out of 132 patients receiving pentazocine and 1 out of 112 receiving cyclimorph, dihydrocodeine, or pethidine reported their occurrence. A total of 135 patients who received pentazocine for disorders likely to require longterm analgesia were followed up for six months after their discharge from hospital. 24 had received pentazocine after discharge; two required an increase in dosage and four expressed a preference for pentazocine.

Adolescent↗
PubMed1972

Haemostatic changes during dialysis associated with thrombus formation on dialysis membranes.

Platelet counts, coagulation factors, and the fibrinolytic system were studied in seven regular dialysis patients during the course of haemodialysis by parallel flow (Gambro-Alwall) and coil (Travenol Ultra-Flo 100) dialysers. Significant falls in the patients' platelet counts and rises in their factor V levels were found with both dialysis systems. The changes were more pronounced over the course of a Gambro-Alwall dialysis, when significant falls in the partial thromboplastin clotting time and in the plasminogen levels were also noted. These haemostatic changes were associated with the retention of platelets on the dialysis membranes and, in the case of the Gambro-Alwall dialyser, with the formation of platelet-fibrin thrombus. This thrombus formation may take place in spite of efficient heparin anticoagulation and may cause excessive blood loss to the regular dialysis patient.

Blood Cell Count↗
PubMed1969

Fibrin degradation products in normal and abnormal pregnancy and parturition.

The levels of fibrin, fibrinogen degradation products (F.D.P.) in the serum were investigated in normal pregnancy and parturition, after caesarean section, and in patients with abruptio placentae, eclampsia, intrauterine death, and post-partum haemorrhage. No significant change occurred during normal pregnancy, but a highly significant increase was found during labour and again during the first week after normal delivery. After caesarean section the levels of F.D.P. were increased two to four hours after operation, and substantially higher levels were found three to eight days after operation than after normal delivery. High levels of F.D.P. were associated with abruptio placentae and eclampsia, and increased levels after intrauterine death and post-partum haemorrhage.An excess of F.D.P. with diminished or normal systemic fibrinolytic activity suggests that local intravascular fibrin deposition and fibrinolysis occur in normal parturition and in these complications of pregnancy. The very high levels of F.D.P. found in abruptio placentae will be important in the pathogenesis of the defective haemostasis that may accompany this complication.

Abruptio Placentae↗
PubMed1969

Plasminogen-activator-producing tumour.

In a patient with giant-cell carcinoma of the lung a secondary tumour deposit in the arm was incised and bled for three weeks. Investigations showed the tumour to be rich in plasminogen activator. Haemostasis in the tumour was achieved with aminocaproic acid therapy. For a period the plasminogen-activator properties were retained in cell culture of the tumour.

Aged↗