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Biomedical subjects

J F Curran

Publications and source records attributed to J F Curran.

25 records · Page 2Linked to original sources

Rheumatologic aspects of painful conditions affecting the shoulder.

Patients with shoulder arthritis present to the orthopedic surgeon due to joint pain and loss of shoulder motion. A differential diagnosis is established, based on the history and physical examination and selected laboratory tests and roentgenograms. Synovial fluid analysis is often very helpful in the diagnosis of shoulder arthritis and critical for differential diagnosis of inflammatory, degenerative, and septic arthritis. Shoulder involvement in primary osteoarthritis is uncommon. The shoulder is rarely the initial joint involved in rheumatoid arthritis. Several uncommon conditions, e.g., amyloid arthropathy and reflex sympathetic dystrophy syndrome, may present early and frequently in the form of shoulder pain. The results of treatment are determined by etiology of shoulder joint disease. Patients with shoulder involvement in rheumatoid arthritis generally respond to the basic management for rheumatoid arthritis. Physical therapy to improve the range of motion of the shoulder and anti-inflammatory medications, including intra-articular corticosteroids, are helpful in most cases.

Amyloidosis↗

A study of antibody levels in alcoholic, depressive and schizophrenic patients.

A study was undertaken to compare IgG, IgA, IgM, IgE and IgD antibodies in adult alcoholic, depressive and schizophrenic patients with healthy, adult controls. Total IgG, -IgA, -IgM, -IgE, and -IgD and specific-IgE antibodies were assessed using 33 allergens: 12 inhalant and 21 foods. There was no significant difference observed in the total immunoglobulin results between the patients and controls. There were, however, significant differences between the groups for allergen specific-IgE with the depressive patients exhibiting the greatest number of positive test results. The depressives had an over-all t-test value of 10.080 (5% = 1.960), the alcoholics t = 6.800 and the schizophrenics t = 6.015. The most often positive allergens were those from the perennial/mold group, although the most frequently positive single allergen was egg white and 100% of the depressives were sensitive to it. The data in this investigation suggest that psychiatric patients with alcohol dependence, depression and schizophrenia be studied further so that information on a causal relationship between allergen specific-IgE antibodies and these mental disorders can be evaluated.

Adult↗

Comparison of Mus musculus (rodent) antigen specific IgE test results on sensitive asthmatics from two different laboratories.

A series of asthmatics with known sensitivity to Mus musculus (rodent) antigen were compared to non-sensitive asthmatics and normal, nonatopic controls by the Fadal/Nalebuff Modified RAST (F/N RAST) protocol in an attempt to duplicate the results of a similar study in the Cook County Hospital. Two lots of extract material were used in the preparation of the reagent discs. A significant difference was observed between the results obtained on the two lots of extract but not between the results found at Cook County Hospital and Immunodiagnostic Research Foundation when the freshly extracted preparation was used. No clinically positive patient was scored as negative on the F/N RAST system when the fresh extract was used and no clinically negative individual was scored as positive. The over-all concordance of results at the two institutions was 74%, with 26% being equivocal. One patient, originally evaluated as skin test negative, was later re-evaluated and found to be 3+ positive after Immunodiagnostic Research Foundation reported a Class 4 RAST score. These results appear to confirm the findings of Lim and Ganju that rodent antigen causes the formation of specific IgE antibodies in sensitive asthmatics.

Animals↗