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Biomedical subjects

J F Chatal

Publications and source records attributed to J F Chatal.

At least 127 records · Page 7Linked to original sources
PubMed1981

Does the corticoadrenal adenoma with "pre-Cushing's syndrome" exist?

An adrenal tumor was discovered fortuitously in a patient with no clinical features of Cushing's syndrome. On adrenal imaging, there was good uptake in the nodule but no visualization of the contralateral adrenal. The latter was seen, however, in a second scan performed under ACTH treatment. In the hormone assessment, basal cortisol and 17-hydroxycorticoids were normal and cortisol diurnal variation was near normal, but a dexamethasone suppression test and ACTH responses to metyrapone and insulin hypoglycemia were abnormal. Eight months after excision of a spongiocytic-type adenoma, the remaining adrenal was visible on scintigram and the hormonal tests were normal. This pattern suggests that the clinical Cushing's syndrome but enough to suppress partially ACTH and, consequently, visualization of the contralateral gland.

17-Hydroxycorticosteroids↗
PubMed1981

[The diagnostic value of the radioimmunological estimation of prostatic acid phosphatase. Comparative value of the measurement of enzyme activity (author's transl)].

Radioimmunological estimation of prostatic acid phosphatase was carried out in 72 reference subjects, 46 patients with benign prostatic hypertrophy, 106 patients with untreated prostatic carcinoma and 25 patients with a carcinoma of some other origin. The mean concentration in non-acidified serum was 1.3 +/- 0.4 (M +/- SD) ng/ml for the reference group and 1.6 +/- 0.8 ng/ml for the benign hypertrophy group. The upper limit of discriminatory values for the diagnosis of prostatic carcinoma was fixed at 3 ng/ml. Taking this value, the overall percentage of positive results for carcinoma of the prostate was 61% (65/106). The number of cases with a value greater than 3 ng/ml was 3/18 (17%) for stage A, 8/27 (30%) for stage B, 7/13 (54%) for stage C and 47/48 (98%) for stage D. 8% (2/25) of carcinomas of another origin gave a positive result. The results of estimation using the radioimmunological technique were compared with those obtained by the measurement of enzyme activity using para nitro-phenyl phosphate as a substrate in 34 untreated prostatic carcinomas (all stages mixed together). When measurements by both techniques were carried out under the same ideal conditions using fresh sera as soon as possible after the blood was drawn, the result was abnormal in 10 cases out of 12 (83%) for the radioimmunological method and in 8 cases out of 12 (67%) for the measurement of enzyme activity. By contrast, under routine conditions, the positive percentage figures were 77% (17/22) for the radioimmunological technique and only 36% (8/22) for the measurement of enzyme activity. It would thus appear that radioimmunological measurement is more reliable than the measurement of enzyme activity.

Acid Phosphatase↗
PubMed1981

[Diagnosis of aortic aneurysm by scintigraphy and ultrasonography (author's transl)].

Angioscintigraphy, performed on 50 patients suspected of aortic aneurysm and complemented by abdominal ultrasonography in 31 cases, disclosed: -- Three cases of thoracic aortic aneurysm, 2 of which were confirmed by arteriography and surgery. It was impossible to perform surgery in the third case, no arteriography was done. Strict agreement with standard thoracic images had made the angioscintigraphic diagnosis seem correct. -- Twenty-seven cases of abdominal aortic aneurysms confirmed by arteriography or surgery. Ultrasonography disclosed an abdominal aortic aneurysm in 26 cases, 20 of which were confirmed. The agreement of the two procedures in 10 unconfirmed cases (6 positive and 4 negative diagnoses) led us to consider the diagnosis as correct. Angioscintigraphy appears to be a reliable procedure for detecting thoracic and abdominal aortic aneurysms. Ultrasonography is the simplest and least costly procedure for study of abdominal aortic aneurysms.

Adult↗
PubMed1980

The respective roles of gallium 67 citrate scanning and diagnostic ultrasound in detecting suppurations in renal allograft recipients.

The authors report their experiments relative to the advantage of using gallium 67 scanning in the diagnosis of suppurative lesions in renal allograft recipients. Nineteen cases suggesting abscess were analyzed. In 7 cases in which abnormal isotope uptake was noted, a suppuration was detected in the area where the gallium 67 had accumulated. In 2 cases, the abnormal image corresponded to the location of a healing drained abscess, and, in 1 case of pathological uptake at the level of the graft, it was determined that the cause was chronic rejection without suppurative lesion. In 9 cases in which no abnormal focus of uptake was noted, the symptomatology suggesting abscess was eventually attributed to nonsuppurative causes (rejection, urinary fistula, etc.). It is concluded that gallium 67 scanning is a useful means of detecting suppurations in immunodepressed patients undergoing treatment with steroids which prevent the usual signs of suppuration from appearing. Generally, it can be said that diagnostic ultrasound, performed with respect to the area of abnormal gallium 67 uptake, permits optimum determination of the possibilities of an abscess existing.

Adolescent↗
PubMed1978

[The value of gallium 67 citrate in the diagnosis and localisation of deep-seated abdominal abscesses (author's transl)].

Six French Departments of Nuclear Medicine have pooled their results of Gallium 67 citrate scanning, carried out with the aim of demonstrating an abcess. Two hundred and thirty five examinations were performed. During the postoperative period, an abcess was correctly localised in 83 cases out of 89. For the 188 patients undergoing the examination, the reliability was 92%. In cases of suspicion of a subphrenic abcess, precise diagnosis was obtained in 19 cases out of 21. In 35 patients with an infectious syndrome in the absence of surgery, scanning gave an accurate diagnosis in 33. In 12 patients who had recently had a renal transplant, scanning revealed a purulent collection in 5 cases. By virtue of the affinity of Gallium for any inflammatory process, echotomography must always be performed after the isotope scan in order to confirm the presence or absence of a fluid collection in the region of the zone of increased uptake. These atraumatic techniques, easy to carry out, should provide clinicians with precious information when an infectious process within the abdomen is being sought.

Abdomen↗
PubMed1978

[Value of isotope study with ytterbium-169 citrate in the diagnosis of pulmonary opacities of cancerous nature].

Out of 60 observations, the authors deduct the value of the isotopic study with Ytterbium169 citrate in the diagnosis of cancerous pulmonary opacities. Ytterbium169 is a radiolanthanide with a period of 32 days. Patients receive intravenously 500 muCi of Ytterbium169 citrate. Recordings are made on the 2nd, 7th and 14th day. Valuable information on the data of the fixation rate on the 2nd and 14th day can be obtained from drawing a curve of fixation. As shown by the dosimetric study the radioactive pollution is minimal; nevertheless the dose of irradiation should not be underestimated and not recommended for young patients. Reliability of the examination is great: the percentage of true positive results is satisfactory (87%) and above all the percentage of false positive results (7.7%) much below that of other isotopes (30-40%). Results are excellent for peripheral opacities which escape the usual diagnostic mean. The main failure of the examination is the relatively frequent lack of fixation, not prejudicial in itself as it has no diagnostic value. Indications and limits of this examination are drawn from this study.

Age Factors↗