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Biomedical subjects

J F Bale

Publications and source records attributed to J F Bale.

100 records · Page 6Linked to original sources
PubMedDate not supplied

Neuroradiographic abnormalities in congenital cytomegalovirus infection.

To determine the spectrum of neuroradiographic abnormalities associated with congenital cytomegalovirus (CMV) infection, CT brain scans of 15 infants with symptomatic infection were reviewed. The initial CT scans were abnormal in 13 patients. Abnormalities included intracranial calcifications, cortical atrophy, ventricular enlargement, subdural effusions, porencephaly and polycystic encephalomalacia. Intracranial calcifications were present in 33% of the infants. In addition, three of the 15 infants developed progressive hydrocephalus which required ventriculoperitoneal shunt placement. These cases illustrate that congenital CMV infection causes a variety of structural CNS lesions and suggest that progressive hydrocephalus may be a relatively common consequence of symptomatic congenital CMV infection.

Atrophy↗
PubMedDate not supplied

Magnetic resonance imaging in childhood disseminated encephalomyelitis.

We report the magnetic resonance imaging features in two children with post-infectious disseminated encephalomyelitis. Magnetic resonance imaging dramatically demonstrated multiple white matter lesions in both children and resolution of lesions in conjunction with clinical recovery. These cases indicate that magnetic resonance imaging has considerable diagnostic utility in disseminated encephalomyelitis of childhood.

Brain↗
PubMedDate not supplied

Congenital fourth nerve palsy and occult cranium bifidum.

A 6-year-old girl had paresis of the fourth cranial nerve since infancy. Computed tomography and magnetic resonance imaging revealed occult cranium bifidum with elevation of the straight sinus and tentorium, an abnormal tectal configuration, and a mass in the posterior fossa. Surgical resection revealed that the mass consisted of adipose and fibrous connective tissue. This patient further illustrates that congenital fourth cranial nerve palsy is associated in rare instances with anomalies of the brainstem and adjacent structures.

Brain Neoplasms↗
PubMedDate not supplied

Human cytomegalovirus nucleic acids in tissues from congenitally infected infants.

In situ nucleic acid hybridization methods were used to study autopsy tissues from 2 infants with clinical or pathologic evidence of congenital cytomegalovirus infections: a premature infant with multiple congenital malformations and inclusion bodies in several organs and an infant with culture-proved symptomatic congenital cytomegalovirus infection. Cytomegalovirus nucleic acids were detected in lung, kidney, adrenal, thyroid, skin, pancreas, and anterior pituitary tissues. In the second infant, hybridization studies of neural tissues failed to reveal cytomegalovirus nucleic acids despite neuropathologic abnormalities consisting of extensive necrotizing ependymitis and periventricular cavitation.

Cytomegalovirus↗
PubMedDate not supplied

Recurrent lateral rectus palsy in childhood.

Five patients with recurrent, lateral rectus palsy in childhood, examined at the University of Iowa Hospitals over a period of 22 years, are reported. During the same period, 131 abducens nerve palsy patients, younger than 18 years of age, were evaluated. Eighteen similar patients, most single case reports, are reviewed from the literature. All reported patients, including our own, shared the following features: spontaneous recovery within 6 months in the majority of patients, ipsilateral recurrence, and painless palsy. There is female and left-sided preponderance. Etiology is undetermined. Hypotheses include viral etiology, neurovascular compression by aberrant artery, and migraine.

Abducens Nerve↗
PubMedDate not supplied

Pubertal arrest associated with valproic acid therapy.

Valproic acid has previously been demonstrated to decrease the secretion of multiple pituitary hormones; however, clinical symptoms associated with decreased hormone secretion have not been described. A girl is reported with complex partial seizures who was treated with valproic acid from age 10 years, 7 months to 12 years, 1 month and during this time had an arrest of both growth and secondary sexual development. Two months after discontinuing valproic acid she had resumption of both pubertal growth and maturation. A prospective controlled study is needed to determine more precisely the effects of valproic acid on growth and development.

Body Height↗
PubMedDate not supplied

Survival of cytomegalovirus in paper diapers and saliva.

We studied the survival of human cytomegalovirus inoculated experimentally into saliva and urine-soaked paper diapers. Infectious virus could be recovered from saliva maintained at room temperature or 37 degrees C for up to 2 hours after inoculation. Cytomegalovirus survived in paper diapers for periods as long as 48 hours, with the quantity of virus in urine remaining relatively constant for the initial 12 hours. These observations provide further support for the concept that fomites may have a role in the transmission of cytomegalovirus infections.

Adult↗
PubMedDate not supplied

Cytomegalovirus infection in burn patients.

We studied the seroepidemiology of cytomegalovirus (CMV) infection in 59 patients with thermal injuries. Among the 31 patients who were initially CMV seronegative, seven (22.5%) seroconverted. Patients who seroconverted had longer hospital stays (mean, 27 +/- 23.9 days v 14.9 +/- 8.8 days in seronegative patients [P = 0.03]) and they received more blood products (mean, 10.7 +/- 17.9 units v 1.8 +/- 2.8 units [P = 0.02]) than patients who remained seronegative. Among 18 patients who were initially seropositive for CMV, 10 (56%) had a fourfold or greater rise in CMV antibodies, evidence of CMV reactivation. Patients who had reactivated CMV infection tended to be younger, to have a larger burn area, and to have a longer hospital stay. No patient who experienced CMV infection, whether primary or reactivated, had serious complications attributable to CMV.

Antibodies, Viral↗