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Biomedical subjects

J Esteve

Publications and source records attributed to J Esteve.

103 records · Page 6Linked to original sources
PubMed1982

Comparative assays in three laboratories of serum specimens containing pregnancy-specific beta 1 glycoprotein with different proportions of the alpha variant.

Following several reports that the alpha component of pregnancy-specific beta 1 glycoprotein (SP1) gives dose-response curves that are flatter than those of the beta component when assayed by radioimmunoassay of the competitive type, a collaborative study was carried out by 3 laboratories to examine whether radial immunodiffusion or rocket immunoelectrophoresis give similar result. Five sera from pregnant women at the 34-39th week of gestation with beta : alpha ratios of 0.8-4.7 were assayed by both the latter methods against either the IARC 78 610 reference preparation of the SP1 Behring standard. When preparations were assayed by rocket immunoelectrophoresis (two laboratories), the dose-response curves were parallel. When preparations were assayed by radial immunodiffusion (two laboratories), parallelism was observed (one laboratory) after the addition of polyethylene glycol, the presence of which is necessary to visualize immune precipitates in which alpha is involved. Discrepancies observed when methodologies such as competitive radioimmunoassay are used, in which there are limited amounts of antibodies, are explained, at least partially, but the fact that the beta component has a greater relative affinity for the antibody as higher concentrations of beta : alpha mixtures are assayed. However, when antibody is present in excess, as in radial immunodiffusion and rocket immunoelectrophoresis, no such difference in affinity seems to occur.

Australia↗
PubMed1981

The evaluation of the effect of the venous tonic 263-E on capillary permeability in the rabbit after administration by intradermal and intravenous routes.

The effects of 2,5-dihydroxybenzene-1,4-disulphonic acid-bisdiethylamine salt (263-E) and trihydroxyethylrutoside (Vitamin P4) on capillary permeability have been compared in the rabbit. Both drugs were administered by intradermal and intravenous routes. Histamine and bradykinin were injected intradermally to increase permeability. 263-E was sown to be a potent inhibitor of permeability changes induced by histamine and bradykinin intravenous routes. Vitamin P4 maximally inhibited permeability at the lowest intravenous dose level but with increasing dose the inhibition became negligible. After intradernal administration, vitamin P4 did not inhibit permeability but potentiated the permeability response induced by histamine and bradykinin.

Animals↗
PubMed1980

Tobacco use, occupation, coffee, various nutrients, and bladder cancer.

In a Canadian population-based case-control study of 480 males and 152 female case-control pairs, the relative risk for development of bladder cancer for ever used versus never used cigarettes was 3.9 for males and 2.4 for females, with a dose-response relationship in both sexes. A reduced risk was associated with the use of filter cigarettes compared to nonfilter cigarettes. After control for cigarette usage, a significant risk was noted for male pipe smokers. For male ex-smokers the risk after 15 years of no smoking was less than one-half that of current male smokers. Bladder cancer risk was found for workers in the chemical, rubber, photographic, petroleum, medical, and food processing industries among males and for workers occupationally exposed to dust or fumes among both sexes. Bladder cancer risk was elevated for males consuming all types of coffee, regular coffee, and instant coffee and for females consuming instant coffee, but no dose-response relationship was found. Risk was found for males consuming water from nonpublic supples but not for females. No risk was observed in males or females consuming nitrate-containing foods, beverages other than coffee, or fiddlehead greens. Hair dye usage in females and phenacetin usage in males and females carried no risk. Divergent findings by area for aspirin suggested that an overall association was not causal. Reevaluation of the data on artificial sweeteners confirmed a significant bladder cancer risk in males and a dose-response relationship. The cumulated population attributable risk for bladder cancer was 90% for males from cigarette smoking, industrial exposure, and exposure to nonpublic water supplies and 29% for females from cigarette smoking, industrial exposure, and instant coffee consumption.

Age Factors↗
PubMedDate not supplied

Single and multiple dose pharmacokinetics of sultosilic acid in humans.

Single and multiple oral doses of Sultosilic acid were administered to four healthy volunteers. Plasma and Urine levels of unchanged Sultosilic acid (I) and its major metabolite (II) were measured. I and II were extracted from plasma and urine with chloroform after ion-pair formation and analysed by HPLC using a U.V. detector. Sultosilic acid was well absorbed and the plasma concentrations declined bioexponentially with mean half-lives of 1.9 h (fast disappearance phase, alpha) and 17.6 h (slow disappearance phase, beta) for I and 2.0 h (alpha) and 17.0 h (beta) for II. Renal clearances of I and II were 50.5 ml/min and 74.8 ml/min respectively. 60% of the administered dose was excreted in urine, 28% unchanged (I), the remainder as carboxylic derivative (II). Minimal drug concentrations in plasma in the range of those detected in steady state conditions were already found within the first day of treatment.

Adult↗
PubMedDate not supplied

[Congenital renal arteriovenous fistula].

On the occasion of a recent observation in our Centre of a case of congenital renal arteriovenous fistula, we make a review of the literature and give a detailed description of the clinical case presented. We stress the difficulty in differentiating between congenital and acquired fistulae and explain the course of therapy currently used.

Adult↗
PubMedDate not supplied

[Perineal ectopic testis].

The authors present three cases of perineal, testicle ectopia, two of which were diagnosed and treated in the Urology Department of the "La Fe" Hospital. The other observation was diagnosed and treated by one of us privately. The treatment was surgical in all the cases and good results were obtained in them all. They discuss the etiopathogeny, clinical characteristics and the uselessness of hormone treatment.

Adolescent↗
PubMedDate not supplied

Simultaneous occurrence of B-cell chronic lymphocytic leukemia and chronic myeloid leukemia with further evolution to lymphoid blast crisis.

The coexistence of chronic myeloid leukemia (CML) and B-cell chronic lymphocytic leukemia (CLL) in the same patient is rare. A 71-year-old woman developed a B-lineage lymphoid blast crisis at 18 months after diagnosis of Ph-positive CML. At this time, a lymphoid cell population with morphologic and immunophenotypic features of CLL was demonstrated. The retrospective review of the tests performed at diagnosis and thereafter disclosed the presence of lymphoid nodules in the initial bone marrow biopsy in the absence of lymphocytosis. Subsequently, there was an appearance of moderate lymphocytosis in the following months. Therefore, diagnosis of CML and coexistent CLL was established. Although a transient remission of blast crisis was achieved, blast cells reappeared two months later and the patient died shortly afterwards. Molecular studies of the immunoglobulin heavy chain gene (IH) rearrangement pattern point to the origin of the diseases in two different cell clones. In addition, previously published cases of simultaneous CLL and CML are reviewed.

Aged↗