Search PubMed⌕ Search

Biomedical subjects

J Esteban

Publications and source records attributed to J Esteban.

At least 91 records · Page 5Linked to original sources
PubMed1995

Long interval between HCV infection and development of hepatocellular carcinoma.

A high prevalence of HCV infection has been reported in patients with hepatocellular carcinoma. The progression from acute transfusion-associated hepatitis to hepatic cirrhosis and hepatocellular carcinoma has been suggested in several studies to be very long. We have investigated the prevalence of anti-HCV and the interval between HCV infection and hepatocellular carcinoma among 191 consecutive patients with cirrhosis and liver-cell carcinoma. Serum samples from 191 patients with cirrhosis and hepatocellular carcinoma, consecutively diagnosed in our hospital between 1988 and 1993, were tested for serological markers of HBV and HCV infection. One hundred and forty-eight patients (77.5%; 95% confidence interval (c.i): 76% to 80%) were anti-HCV positive by 2nd generation enzyme immunoassay (confirmed by 2nd generation recombinant immunoblot assay) and 152 patients (79.5%; 95% c.i: 76% to 80%) were anti-HCV positive by 3rd generation enzyme immunoassay, while only 14 (7.4%; 95% c.i: 5% to 10%) were HBsAg positive. Of the 29 anti-HCV positive patients with previous transfusion, the interval between the date of blood transfusion and the diagnosis of hepatic cirrhosis was 24 +/- 12.5 years and that of hepatocellular carcinoma was 26.8 +/- 12.4 years. These results confirm the high prevalence of HCV infection in patients with hepatocellular carcinoma and the slow sequential progression from HCV infection through cirrhosis and hepatocellular carcinoma.

Carcinoma, Hepatocellular↗
PubMed1995

[Extrapulmonary tuberculosis. Experience at a general hospital (1980-1993)].

In order to know extrapulmonary tuberculosis in our environment the results of all samples submitted for culture of mycobacteria to the Microbiology Department, Fundación Jiménez Díaz, from 1980 to 1993 were analyzed. During this period 290 cases of extrapulmonary cases were diagnosed, 101 from 1980 to 1985 and 189 from 1986 to 1993. The most common site of infection before 1985 was in genitourinary tract (42.6%); in contrast, from 1986 onwards the more common sites of infection were pleural (22.8%), genitourinary tract and lymphatic glands (22.2% in both sites). When EPT was compared in the two periods of time the observations made were a relative decrease of genitourinary infections (p = 0.00004) and increase in disseminated (p = 0.015) and pleural tuberculosis (p = 0.011) from 1986 compared with previous years. From 1986 a greater proportion of disseminated form was observed (p < 0.0001) in positive-HIV patients and of genitourinary (p = 0.011) and pleural (p = 0.076) forms in negative HIV-patients. In conclusion, extrapulmonary tuberculosis has increased in our environment during the period 1980-1993, and this increase is not attributable only to positive-HIV patients. The distribution of clinical forms of this disease was different in the two studied periods and among positive and negative HIV patients.

HIV Infections↗
PubMed1995

[Tuberculous meningitis: prognostic aspects of 22 microbiologically confirmed cases].

BACKGROUND: Tuberculous meningitis continues to be a severe disease difficult to diagnose within a reasonable time carrying a high morbimortality. METHODS: A retrospective review of cases of microbiologically confirmed tuberculous meningitis diagnosed and treated in the authors' institution is presented. RESULTS: From 1974-1993, 22 patients (12 males and 10 females, mean age of 31.5 years; range: 4 months and 77 years) were studied. Eighteen patients (81%) presented extrameningeal tuberculosis. Seven (31.8%) died and 6 (27.3%) presented severe neurologic sequelae. The worst prognosis was observed in patients older than the mean (p = 0.03), worse neurologic situation on admittance (p = 0.03) and hydrocephaly diagnosed by imaging techniques (p = 0.04). Corticoids were administered in 15 patients (68%) without contributing comparatively to better disease prognosis. CONCLUSIONS: The authors consider that the initiation of specific early treatment in justified while awaiting microbiologic confirmation of the disease.

Adolescent↗
PubMed1995

[Soft-tissue infection caused by Aeromonas hydrophila].

BACKGROUND: Two cases of soft tissue infection by Aeromonas hydrophila are presented with review of the literature. PATIENTS AND METHODS: Two cases of soft tissue infection by Aeromonas hydrophila diagnosed from 1992-1993 are reported. RESULTS: Most soft tissue infection produced by Aeromonas organisms are caused by Aeromonas hydrophila. These infections predominantly affect the lower limbs of middle-aged males with previous history of injury favoring infection. The most common clinical presentation is cellulitis with a good prognosis if bacteremia is not produced. Antibiotics, such as mainly third generation cephalosporins, imipenem, aztreonam, cotrimoxazole, tetracycline, chloramphenicol, quinolones and aminoglucosides (except streptomycin) are usually very active in vitro against these organisms. Surgery is often necessary to cure the process. CONCLUSIONS: Cellulitis by Aeromonas hydrophila is a very infrequent entity in Spain and is usually associated to previous injury and probable contamination by environmental bacteria.

Adult↗
PubMed1995

[Evaluation of 3 culture media for isolating mycobacteria from extrapulmonary samples].

OBJECTIVE: To compare three different media (Middlebrook 7H11, Löwenstein-Jensen and MB-Check System) for the isolation of mycobacteria from extrapulmonary samples in a routine medium-size microbiology laboratory. MATERIAL AND METHODS: Extrapulmonary samples were processed for mycobacterial isolation during a 22-month period, and the three media above described were evaluated in paralell during the usual routine work. RESULTS: 907 extrapulmonary specimens were processed during the study period, being the MB-Check system the most sensitive medium for detection of mycobacterial growth (79.3%) compared with Middlebrook 7H11 (62.2%) and Löwenstein-Jensen (71.8%), increasing the overall sensitivity in 11.1%. However, the fastest medium for detection of mycobacterial growth was Middlebrook 7H11 (18.2 days) compared with Löwenstein-Jensen (21.6 days) and MB-Check (23.8 days), despite the higher rates of contamination detected in Middlebrook 7H11 (61.4% compared with 10.8% for Löwenstein-Jensen and 6.1% for MB-Check). CONCLUSIONS: The combination of the three studied media is a useful alternative for isolation of mycobacteria from extrapulmonary specimens in medium-size laboratories.

Body Fluids↗
PubMed1994

Isolation of Nocardia sp. from blood cultures in a teaching hospital.

To determine the clinical significance of the isolation of Nocardia sp. from blood cultures, clinical records of patients with bacteremia due to Nocardia sp. in our hospital from January 1986 to December 1990 were retrospectively reviewed. Eight patients had 9 blood cultures positive for Nocardia sp. Four of the isolates were identified as Nocardia asteroides. Only 2 of the patients had disseminated nocardiosis due to N. asteroides, and both were appropriately treated for Nocardia sp. In the other cases, isolation of Nocardia sp. was considered nonsignificant or undetermined, and all were clinically cured. Nocardia sp. may be an occasional contaminant of blood cultures. The significance of nocardemia is a matter of clinical judgment.

Adult↗
PubMed1993

Cytopathic effect mimicking virus culture due to Mycobacterium tuberculosis.

Mycobacterium tuberculosis grew, from a bronchoalveolar lavage of a patient with AIDS, on a gentamicin-supplemented cell culture monolayer, causing a focal and slowly spreading cytopathic effect resembling that of a virological isolate. The same effect was observed after inoculation of two different inocula of M. tuberculosis onto the same cell culture.

Acquired Immunodeficiency Syndrome↗