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Biomedical subjects

J Eshchar

Publications and source records attributed to J Eshchar.

At least 55 records · Page 3Linked to original sources
PubMed1986

Gastrointestinal endoscopy in octagenarians.

Seventy-five patients, 80-90 years old, each having approximately three associated diseases, underwent a total of 104 gastrointestinal endoscopies. Of these, 73 were upper (29 emergencies) and 31 lower endoscopies (21 were rigid sigmoidoscopies). There were two very mild short-lived complications; vomiting and bleeding. We found 16 gastric ulcers, 16 duodenal or pyloric ulcers, and 11 cases of esophagitis. Bleeding duodenal (8) or gastric (4) ulcers and polyps or malignant tumors (7) were seen less often. In 34 of 68 lesions the endoscopic and x-ray findings were the same. In the other 34 there were 10 endoscopic failures to identify colonic diverticula, hiatus hernia, and gastroesophageal reflux that were seen radiologically. In 24 patients, diagnoses were not made radiologically, but were recognized at endoscopy. The safety and accuracy of endoscopy in the old and sick does not differ from that in younger patients.

Aged↗
PubMed1986

Serum beta-N-acetyl hexosaminidase levels in chronic renal failure.

Serum beta-N-acetyl hexosaminidase (beta-NAH) levels, the indirect indicators of hepatic endothelial and Kupffer cell function, were examined in 16 anuric chronic hemodialysis patients, and in 11 patients in different stages of chronic renal failure (serum creatinine 2-8.8 mg/dl). They were found to be lower than those of the healthy controls, contrary to expectation. It might be concluded that nonparenchymal liver cells are functioning well in chronic renal failure. However, the possibility that production of beta-NAH in these patients is abnormally reduced cannot be excluded.

Adult↗
PubMed1985

Chemical burns of the upper gastrointestinal tract.

Burns of the upper gastrointestinal tract, caused by acids, alkalis, drugs or heat may lead to stenoses, some of them severe, to perforations, to inanition and to the patient's death. The type of damage differs among the various groups of noxious agents. First aid at home is almost non existent. On admission every effort must be made to identify the ingested material. Parenteral fluids and antibiotics are used and in some patients nutritional support will be required. The extent of the damage must be evaluated endoscopically. Strictures, caused by intramuscular collagen formation, could possibly be prevented by steroid therapy. If stenoses occur, these must be cautiously dilated. A late complication of oesophageal burns is carcinoma. There appears to be a relation between this grave complication and the use of very hot beverages in certain countries where oesophageal cancer is common. Upper gastrointestinal burns are similar to skin burns, however, their dangers may be greater as they occur in a pipe-like structure and very close to vital viscera.

Acids↗
PubMed1985

Hepatotoxicity of hornet's venom sac extract in isolated perfused rat liver.

The changes in the activity of some enzymes in parenchymal liver cells were measured in the perfusate of rat isolated liver after a single envenomation with two different doses of Hornet's (Vespa orientalis) venom sac extract (VSE). The maximal observed enzymatic changes were significant: twenty four fold rise of alkaline phosphatase E.C.3.1.3.1(ALP), six fold rise of alanine aminotransferase E.C.2.6.1.2. (ALT) and nine fold rise of aspartate aminotransferase E.C.2.6.1.1. (AST) activity. There were moderate changes (four fold) in lactic dehydrogenase activity E.C.1.1.1.2.7. (LDH) and a non-significant change in gamma-glutamyl-transferase E.C.2.3.2.1. (GGT) activity. These changes varied with the venom's dose. Also a decrease in the rate of effluent draining out via the hepatic vein was noted as an additional sign of liver damage. In light of the biochemical evidence presented here, as well as in previous work, it seems that no further biochemical proof is needed to establish the hepatotoxicity of VSE in rats, cats and probably humans too. It seems that VSE is a predictable hepatotoxin causing a pattern of enzyme changes of the cholangiocellular type.

Alanine Transaminase↗
PubMed1984

Double pylorus or antro-bulbar fistula.

A patient suffering from rheumatoid arthritis and a gastric ulcer was found endoscopically to have a double pylorus. One year later the two apertures were found to be fused and appeared endoscopically like a deformed pylorus. We suggest that this lesion, which is usually acquired but may sometimes be congenital, would be better called antro-bulbar fistula.

Adult↗
PubMed1983

Hornet (Vespa orientalis) venom sac extract causes hepatic injury in cats.

1. Injection of sublethal doses of hornet venom to cats was followed by increases in serum aminotransferases and alkaline phosphatase, together with hyperglycemia, uremia and hyperkalemia. 2. The blood pH and PO2 fell significantly. 3. All changes occurred within 30 min of injection and were found to be partially reversible. 4. These results may be due to specific liver cell injury. 5. The possibility of a generalized metabolic effect, such as shock, cannot be discounted, although it is quite unlikely.

Animals↗
PubMed1983

Hepatotoxicity of hornet's venom sac extract, after repeated in vivo and in vitro envenomation.

The activity of some enzymes involved in hepatic function was measured in rats, in vivo, after one week's repeated envenomation with Hornet's (Vespa orientalis) venom sac extract (VSE) and in vitro in monolayers of tissue culture of rat hepatocytes treated with VSE. The maximal serum enzymatic changes observed in vivo were significant: twenty fold rise of alkaline phosphatase (ALP), a 7-8 fold rise of aspartate aminotransferase (AST) and a 4-5 fold rise in alanine aminotransferase (ALP) activity. Also 2-3x increases of both serum lactic dehydrogenase (LDH) and creatine phosphokinase (CPK) were noted. The maximal in vitro changes were observed after six days of daily envenomation. There were five fold rises of the activity of AST in the medium, as well as of two-three fold rises of ALT, ALP and LDH. These changes suggest that Hornet's VSE induces enzymatic changes in the liver after prolonged, repeated exposures. They also exclude a general effect, like shock, that might possibly occur in the intact animal, as the cause of the demonstrated hepatic damage.

Animals↗
PubMed1983

Zollinger-Ellison syndrome, prolonged cimetidine administration and nasopharyngeal carcinoma:--a coincidence?

A patient with Zollinger-Ellison syndrome who developed an undifferentiated nasopharyngeal carcinoma (NPC) after 3 years of daily treatment with a least 1.0 g cimetidine is described. The question is raised whether large doses of cimetidine, administered for long periods to patients perhaps already immunologically compromised, may change T-suppressor cell functions so as to enable proliferation of oncogenic viruses (e.g. EB virus) and the appearance of tumor. We feel that when the population at risk is small, even a solitary case should alert all concerned.

Cimetidine↗