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Biomedical subjects

J Escourrou

Publications and source records attributed to J Escourrou.

89 records · Page 5Linked to original sources
PubMed1977

[Problem posed by the prevention and detection of colorectal cancers].

The incidence of colonic and rectal carcinoma is in constant progression. The detection and destruction of polyps is the only effective means of reducing the number of adenocarcinomas. The technical means of detection are well known and fully proved: rectosigmoidoscopy, thin layer double contrast enema, colonoscopy. The true problem is that of the cost of this prevention. It is important to define high risk groups in which these tests should be carried out as a routine. Furthermore it is necessary to know whether blood tests or examination of the stools may be considered as a means of detection of polyp or at least certain types of potentially malignant polyp. without suggesting a considerable increase in the number of medical investigations, one may hope for better use of sigmoidoscopy and double contrast barium enema. These two examinations represent undoubtedly the essential factor in the diagnosis of colonic and rectal tumours.

Adenocarcinoma↗
PubMedDate not supplied

[Functional pancreatic studies in the diagnosis and treatment of chronic pancreatitis].

The diagnosis of chronic pancreatitis is usually established by clinical history and morphological criteria based on radiological and/or endoscopic (ERCP) findings. When these morphological signs are absent or equivocal, pancreatic function testing is necessary. Direct testing by duodenal intubation with hormonal stimulation is still considered as the reference method ("gold standard"). Numerous indirect tests have been introduced to replace the duodenal intubation which is rarely well accepted and difficult to repeat. Moreover this technique is only available in highly specialized centres. Among the tubeless tests, the Paba test and the pancreolauryl test are gaining interest. Several modifications of these tests have improved their sensitivity and specificity. In most instances, these tests are unable to detect mild pancreatic insufficiency. However their reproducibility in individual cases could be useful for the follow-up of patients with proven pancreatic insufficiency, particularly with regard to the efficacy and the compliance of replacement therapy.

Chronic Disease↗
PubMedDate not supplied

[Incidence of colorectal cancer in the Haute-Garonne Department. Evaluation of 2 years of registration (1982-1983)].

During a two-year period ending in 1983, 882 colorectal cancers (CRC) were diagnosed among 820,000 residents in the department of Haute-Garonne (France). The age-standardized incidences were 24.3 and 19.1 per 100,000 in men and 15.2 and 9.5 per 100,000 in women, for colon and rectal carcinomas respectively. The Haute-Garonne population-based registry showed one of the highest rates of risk of CRC in Europe. A relatively high incidence of rectal cancer, a marked male preponderance particularly in left-side colon cancers, and a higher mean age in female patients (67.1 +/- 11.6 and 70.2 +/- 11.9 (p less than 0.001] was observed. Distribution of CRC within the department was heterogeneous. Although there was no significant difference between urban and rural areas, some regions showed a higher incidence (the "Volvestre" in both sexes and the "Riviere" in women) whereas the "Pyrénées Centrales" showed a lower incidence in women only. CRC was often diagnosed at an advanced stage (Dukes A: 26.1 p. 100, Dukes B: 22.2 p. 100, Dukes C: 27.4 p. 100, visceral metastases: 24.4 p. 100 especially in women (p less than 0.02). Among symptom-free patients (4.5 p. 100) cancers limited to the colonic wall represented 71.4 p. 100 of cases. This suggests that prognosis of CRC could be improved by routine screening of healthy populations. Surgery was performed in 91 p. 100 of colonic cancers and 85 p. 100 of rectal cancers but was considered to be curative in only 55 p. 100 of all cases.

Adult↗