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Biomedical subjects

J Eschar

Publications and source records attributed to J Eschar.

9 recordsLinked to original sources
PubMed1990

Bile acids in rat serum as indicators of hepatotoxicity by hornet venom.

The effect of hornet venom sac extract (VSE) on hepatic function in rats was evaluated by measurement of bile acid (BA) levels. A significant dose-dependent elevation of BA in rat serum upon repeated VSE administration was found. Rats envenomed for 2 weeks showed a significant rise of serum BA compared with the controls or with rats envenomed for 6 days. In rats envenomed for 1 week and killed after another week without envenomation, an improvement of the biochemical status was observed. These observations demonstrated that BA levels reflect the VSE-induced hepatic injury. They suggest that the cholestatic effects of VSE may be due to an impairment of bile acid excretion, but the elevations could also reflect parenchymal hepatic injury.

Animals↗
PubMed1985

Histopathological changes in rat liver following repeated vespine envenomation.

The histopathological picture of rat liver was studied after repeated envenomation with hornet (Vespa orientalis) venom sac extract (VSE). Light microscopical and histochemical investigation showed foci of necrosis of the hepatocytes, a decrease in glycogen content and in succinic dehydrogenase activity, some fat infiltration and an increase in alkaline phosphatase activity. Electron microscopy showed a decrease in the number of mitochondria per cell as well as a decrease in their cristae, enlargement of bile canaliculi, and destruction of the endothelium of the sinusoids bringing the cytoplasm of the necrotic hepatocytes in contact with the lumen of the sinusoid. The rat liver is proposed as a model for the study of pathological effects of animal toxins.

Animals↗
PubMed1975

EEG in ulcerative colitis.

Electroencephalographic tracings of 50 patients with ulcerative colitis (UC) were compared with those of 75 controls. In the UC patients a 24% incidence of abnormal tracings was found as compared with an 8% incidence in the controls. A higher incidence of abnormal electroencephalograms was found among active cases of UC than among those in remission. The meaning of these results is not yet clear.

Colitis, Ulcerative↗