Biomedical subjects
J England
Publications and source records attributed to J England.
Cell-mediated immunity in horses with sarcoid tumors against sarcoid cells in vitro.
Cell-mediated immunity in horses with sarcoid tumor against sarcoid antigens was studied in vitro by means of mixed lymphocyte tumor cell culture assay and lymphocyte-mediated cytotoxicity of 52Cr-labeled target cells. When Mc-1 sarcoid cells were used as stimulatory cells for peripheral blood lymphocytes in the mixed lymphocyte tumor cell assay, a clear difference in the kinetics of the generated lymphocytic proliferative response could be detected between sarcoid and control horses. With sarcoid horses, their proliferative maximum was reached 3 days earlier than that of the control horses, and at this time their proliferative activity was significantly increased over that of control horses. When normal allogeneic fibroblasts were used as stimulatory cells, no such difference between sarcoid and control horses could be seen. The cellular cytotoxicity of peripheral blood lymphocytes from sarcoid and control horses against Mc-1 cells or normal allogeneic fibroblast targets was very low. However, the mean cytotoxicity against Mc-1 was slightly increased for sarcoid horses as compared with that of control horses. In contrast, the cytotoxicity against allogeneic fibroblasts was slightly lower for sarcoid than for control horses. In contrast, the cytotoxicity against allogeneic fibroblasts was slightly lower for sarcoid than for control horses. Furthermore, it was shown that sarcoid horses, but not control horses, had a slightly but consistently increased cytotoxicity against Mc-1 cells as compared with that against normal allogeneic fibroblasts.
Effect of glucagon and pentagastrin on gastric mucosal potential difference in man.
Glucagon given as an intravenous injection of 2 mg (0.57 mmol) or as constant intravenous infusion of 1.64 microgram/kg/h (0.47 nmol/kg/h) significantly increased gastric mucosal potential difference (PD) in man. Pentagastrin infusion of 2 microgram/kg/h (2.8 nmol/kg/h) dramatically reduced gastric PD in man. The effect of each of these hormones on PD was reversed by the administration of the other. Changes in PD induced by one hormone were not associated with reductions in blood levels of the other. There was an approximate correlation between changes in PD and pH of gastric aspirates, however, the patterns of PD and pH changes were at times dissimilar. This study indicates that administration of gastrointestinal hormones significantly alters gastric mucosal PD in man.
False-negative screen for neural tube defect in spina bifida with stenosis of the aqueduct of Sylvius.
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