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Biomedical subjects

J Eldor

Publications and source records attributed to J Eldor.

At least 91 records · Page 5Linked to original sources

Use of low-dose neostigmine intravenously in the treatment of supraventricular tachycardia: an immediate bradycardic effect.

Neostigmine was first used 50 years ago to treat sinus tachycardia and paroxysmal auricular tachycardia. Then there were reports of successful treatment by neostigmine of other forms of supraventricular tachycardias. However, reports of sudden death using neostigmine for reversal of neuromuscular blockade at the end of an operation, which were not properly treated with atropine abandoned the use of neostigmine as an antiarrhythmic drug. Low-dose neostigmine intravenously was used in the treatment of supraventricular tachycardia in three patients described herein. It gave an immediate bradycardic effect in all three patients. The use of a low-dose neostigmine intravenously for an immediate treatment of supraventricular tachycardia is a novel suggestion. It has to be further evaluated and compared to the conventional drugs used like digoxin, verapamil, propranolol or esmolol.

Adolescent↗

Open chest cardiac massage: a review.

Open-chest cardiopulmonary resuscitation (CPR) is physiologically superior to all external CPR methods studied thus far (P. Safer, Ann. Emerg. Med., 13 (1984) 856). Open-chest CPR should again be taught to physicians, and used more often after prolonged cardiac arrest. An extensive review on open cardiac massage is presented herein.

Heart Arrest↗

Prolonged bradycardia and hypotension after neostigmine administration in a patient receiving atenolol.

A 78-year-old woman admitted for an elective hip operation was maintained on atenolol for control of her hypertension. She received neostigmine and atropine for reversal of muscle relaxation at the end of general anaesthesia. She then developed prolonged bradycardia and hypotension which necessitated the use of adrenaline and isoprenaline. Such an adverse reaction with atenolol has not been described previously.

Aged↗

Births following oral contraceptive failures.

Neonatal outcome was studied in 108 infants conceived while their mothers were taking oral contraceptives. The infants tended to be born to younger, less educated mothers and were more likely to have been exposed to hormonal pregnancy tests. Ten newborns were malformed; 8 of these were males. One was anencephalic, and 1 infant had Down's syndrome. There was also a significantly large number of twins and an excess of perinatal mortality. These results are similar to those of previous studies, showing a small but increased risk of adverse outcome in infants born after oral contraceptive failure.

Abnormalities, Drug-Induced↗