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Biomedical subjects

J Elder

Publications and source records attributed to J Elder.

70 records · Page 4Linked to original sources
PubMed1985

Experimental analysis of adherence counseling: implications for hypertension management.

A time series "reversal" design demonstrated that behavioral counseling increased medication adherence from about 60 to 100% for a black, hypertensive patient. However, inadequate pharmacological treatment yielded no clinically important blood pressure decrease. The combination of improved compliance and minimal blood pressure reduction led the patient's physician to explore higher doses and alternate medications to achieve blood pressure control. The physician's aggressive medical treatment was initiated only after the patient's compliance had been improved. Thus, this study suggests that paraprofessional counseling can increase compliance and illustrates the need for both behavioral and physiological data in clinical management to avoid blaming patients for poorly controlled blood pressure.

Adult↗
PubMed1983

Pathogenesis of the slow disease of the central nervous system associated with wild mouse virus. III. Role of input virus and MCF recombinants in disease.

Inbred mice bearing the FV-1n marker when inoculated at birth with an ecotropic murine leukemia virus (WM 1504-E) obtained from wild mice develop a progressive central nervous system (CNS) disease manifested by hindlimb paralysis and incoordination that begins by 6 to 7 weeks of age. Studies of infected SWR/J mice at 3 days to 4 months of age indicated the following: (1) Expression of MuLV gp69/70 and p30 antigens in CNS rises beginning as early as 3 days after inoculation and increases with time. (2) Neuronal damage is evident by Day 7, and neuronal lesions develop in all mice by Day 14. (3) WM 1504-E virus can be isolated from CNS tissue by 48 hr after initiating infection. (4) Upon passage into susceptible newborn mice, the WM 1504-E isolates cause neuronal disease. (5) "Dual-tropic" mink cell focus forming (MCF) -like virus is found in splenic but not CNS tissues by 8 weeks after initiating infection. (6) MCF viruses that arise by env gene recombination between WM 1504-E and endogenous xenotropic viruses do not cause CNS disease upon inoculation into susceptible newborn mice. Similarly inoculated WM 1504-amphotropic virus (WM 1504-A) does not cause CNS disease (7). Results in SWR/J mice can be duplicated in C3H/St and C57Br/cdj mice. These observations define the wild mouse ecotropic virus as the sole infectious agent responsible and sufficient for the development of this neurologic disease. Evidently, the disease from this "slow virus infection" begins early in life shortly after introduction of the infectious agent, but becomes clinically apparent only as neuronal destruction accumulates over the lifetime of the host.

Animals↗
PubMed1983

The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins.

Monoclonal antibodies allow for the detection of antigens which are specific for human thymus-derived lymphocytes. Among these antigens, the T3 complex is of particular interest since it is involved in several T cell functions. The main target antigen of the anti-T3 reagents is borne by a 20-kDa glycoprotein. In addition, glycoproteins of 25-28, 37, and 44 kDa are found in anti-T3 immunoprecipitates derived from surface-labeled cells. The four antigens appeared to be strongly associated with each other in detergent-containing solutions. Comparative studies of the four proteins, facilitated by the use of endo-beta-N-acetylglycosaminidase F, revealed that their polypeptide backbones have different molecular weights and pI values. Moreover, peptide maps of the 20-kDa T3 and the 25-28-kDa T3 were quite different. Metabolic labeling experiments suggested that the 25-28-kDa protein might become associated with the 20-kDa T3 antigen during biosynthesis. The 37-kDa and 44-kDa proteins could not, however, be detected and, therefore, might become associated with the 20-kDa T3 on the cell surface. Evidence has been found for the existence of a fifth member of the T3 complex, namely an unglycosylated 20-kDa T3 species.

Antibodies, Monoclonal↗
PubMed1982

Problem-solving skills of rural battered women.

Recent research suggests that battered women may have a problem-solving skill deficit, thereby limiting their ability to prevent and/or effectively deal with future battering incidents. Situations encountered by battered women were analyzed by gathering data of 30 women receiving outpatient mental health treatment and of women who used a domestic violence emergency shelter. These situations were administered in an open-ended questionnaire format to 14 battered and 20 nonbattered women. These subjects were asked to develop as many alternatives as they could for each situation. Nonbattered women generated significantly more total alternatives and effective alternatives than did battered women. Battered subjects were more likely to produce avoidant and dependent responses.

Adolescent↗
PubMed1981

Phosphorylation of the Abelson murine leukemia virus transforming protein.

The Abelson murine leukemia virus transforming gene product is a phosphorylated protein encoded by both viral and cellular sequences. This gene product has an amino-terminal region derived from the gag gene of its parent virus and a carboxyl-terminal region of (abl) derived from a normal murine cellular gene. Using a combination of partial proteolytic cleavage techniques and antisera specific for gag and abl sequences, we mapped in vivo phosphorylation sites to different regions of the protein. Phosphoproteins encoded by strain variants and transformation-defective mutants of Abelson murine leukemia virus with defined deletions in the primary sequence of the abl region were compared by two dimensional limit digest peptide mapping. Specific phosphorylation pattern differences for wild-type and mutant proteins probably represented deletions of specific phosphate acceptor sites in the abl region. An in vitro autophosphorylation activity copurified with the Abelson murine leukemia virus protein from transformation-competent strains. A peptide analysis of such in vitro reactions demonstrated that these phosphorylation sites were restricted to the amino-terminal region, and the specific sites appeared to be unrelated to the sites found on proteins phosphorylated in vivo. Thus, the autophosphorylation reaction probably correlates with an activity important in transformation, but the specific end product in vitro bears little resemblance to its function in vivo.

Abelson murine leukemia virus↗
PubMed1977

Effects of mercuric chloride on synchronized Chinese hamster ovary cells: survival and DNA replication.

Chinese hamster ovary (CHO) cells in vitro were treated with HgCl2 at various stages in the cell cycle and the effects of this chemical on cell survival, DNA replication, and cell division were observed. In terms of survival the early G1 cells were the most sensitive to treatment, followed by late G1 and early S, while mid S and late S-G2 treated cells were the least sensitive. Treatment with HgCl2 also resulted in reduced rates of DNA replication and delays in cell division. The early G1 treated cells showed substantially reduced rates of DNA replication followed by 4--5 h division delay. The early S and late S-G2 treated cells had some reduction in their rates of DNA replication followed by corresponding division delay of 2.5 h in the early S treated cells and 1 h in the late S-G2 treated cells.

Animals↗
PubMed1970

Additional factors in chronic bronchitis.

A review of persons with chronic bronchitis and controls without bronchitis showed several irritants around the home that aggravated cough, such as house dust, flowers and grasses, smoke, strong fumes, hair spray, insecticide, and soap powders. Most subjects with bronchitis were affected by exposure to one or more of these irritants for at least once a day for three months of the year or more. Out of 163 subjects with chronic bronchitis only six non-smokers were free of factors associated with pulmonary irritation. This evidence from non-smokers not exposed to air pollution adds further strength to the hypothesis that daily phlegm is caused by persistent inhalation of irritants.

Adult↗
PubMedDate not supplied

The effects of the Child and Adolescent Trial for Cardiovascular Health upon psychosocial determinants of diet and physical activity behavior.

BACKGROUND: The Child and Adolescent Trial for Cardiovascular Health is a multisite study of a school-based intervention to reduce or prevent the development of risk factors for cardiovascular disease. The purpose of this paper is to present the evaluation results of the 3-year intervention, focusing upon the psychosocial variables conceptualized as determinants of dietary and physical activity behaviors. METHODS: A total of 96 schools across four study sites (California, Louisiana, Minnesota, and Texas) were randomized to two treatment conditions: intervention and control. Pre- and postmeasurements on the health behavior questionnaire were collected from over 6,000 students. The data analyses utilized a nested design approach in which schools served as the primary unit of analysis. Repeated-measures multivariate analyses were applied to investigate effect sizes for each determinant and to explore theoretical relationships among the determinants over time. RESULTS: The findings indicated sustained significant effects in improved knowledge, intentions, self-efficacy, usual behavior, and perceived social reinforcement for healthy food choices (P < 0.0001 for these five variables) after 3 years. Intermittent effects were observed for perceived support and self-efficacy for physical activity. No gender by determinant interaction effects were observed, and girls reported significantly greater perceived reinforcement for healthy eating than did boys. CONCLUSION: The CATCH program was effective in changing the psychosocial variables likely to influence a reduction in behavior for cardiovascular disease. The study is significant in that it demonstrates the viability and effectiveness of a sustained multifaceted intervention in a preadolescent population. The results point to a need for greater understanding of adolescent developmental issues and the role of community environment (particularly social support) in creating effective curricula.

Adolescent↗
PubMedDate not supplied

[Legal framework and strategy of the tobacco industry in relation to tobacco advertising in Spain].

Publicity is legally regulated in Spain, in order to avoid its misuse. Tobacco publicity is also under those regulation, having had the companies operating in this sector to adapt themselves through new strategies. In this work, the legal restrictions existing in Spain regarding publicity are analyzed, together with some of the strategies developed by tobacco companies in order to elude them. In this sense, and despite of the existing legal framework, it should be noticed that tobacco companies are cleverly taking advantage of the existence of legal loopholes in tobacco publicity to promote their products.

Advertising↗
PubMedDate not supplied

[Analysis of the publicity campaign of the tobacco brand Fortuna in 1999-2000].

The majority of tobacco advertisement in Spain is directed at youth. This advertisement, carried out on several fronts, is particularly effective with young people. In the present work we analyze different advertising efforts involved in the ad campaign carried out by Fortuna-brand (a product of the company Tabacalera S.A., and sector leader of sales in Spain) in 1999 and 2000. In terms of their marketing strategy, we can conclude that Fortuna's principal commercial objective is presenting tobacco as intrinsically associated with being young. Both the indirect promotion of its products through activities and its commercials, are aimed towards developing the image that tobacco symbolizes the series of core values more appreciated by youth. Relevant legislation will have to be adapted to this reality in order to control specifically the manner in which publicity such as that promoted by Fortuna is directed to the population.

Adolescent↗
PubMedDate not supplied

Epidermal growth factor receptor structure, regulation, mitogenic signalling and effects of activation.

The biological effects of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are mediated by an interaction with a specific cell surface receptor having both intra- and extracellular domains. The structure of the intracellular domain can be closely aligned with retroviral protein tyrosine kinases. Upon ligand-binding there is a change in conformation of the extracellular domain, the receptor being converted to dimeric. Dimeric receptor has a higher rate of catalysis than monomeric and rapidly becomes phosphorylated. This form of the receptor now associates with and phosphorylates enzymes such as phospholipase-C, altering their catalytic activity and subcellular distribution This system appears to stimulate the effects of epidermal growth factor receptor(EGFr) activation, notably proliferation, morphology, paracrine effects and differentation.

Animals↗