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Biomedical subjects

J Egger

Publications and source records attributed to J Egger.

At least 73 records · Page 4Linked to original sources
PubMed1985

A dietary management of severe childhood migraine.

We describe in detail a dietary treatment which has been shown to be effective in most children with severe migraine. Potential adverse nutritional and allergic effects are outlined; because of the diet should be undertaken only in those ill enough to justify it. In the first stage very few foods are given, and if the child responds to this oligoantigenic diet, foods are reintroduced one by one at weekly intervals. In this way foods causing symptoms are identified and eliminated. Research is urgently needed to establish simpler empirical diets and diagnostic tests.

Adolescent↗
PubMed1984

[Psychological adaptation in coronary patients].

Summarizing some essential results from empirical investigations about the individual adaptation and coping with coronary heart diseases five principles are formulated: It ist not possible to predict the individual reactions to a coronary disease from the knowledge of the pathophysiological aspects. The behaviour pattern of these patients are different and complex determined. The individual reactions to the outbreak of the disease equally depend on familial, occupational, social and public health care factors on one side and on intrapsychical factors of the patient on the other side (i.e. personality structure, psychological status before the event etc.). The fact of a coronary or myocardial disease does not necessarily lead to a life-crisis or maladaptation. For the patient's style of life positive and/or negative effects of the disease can be differentiated. The patient's appraisal of a therapeutic success depends therefore on the intraindividual reinforcement-value of such a success. Adaptation and coping strategies are not uniform in phenomenological or time aspects. The emotional, cognitive and behavioural patterns primarily tend to help to cope with anxiety and uncertainty (f.i. denial, depression, aggression, building up a new identity). In the patient's mind a myocardial infarction is not necessarily the most important event in his actual life-situation. Concerning the heart disease fears about the own capacity of work and financial outcome are dominant. They are followed by concerns about the medical prognosis or course of disease, family life and partnership, satisfaction with future life and its meaning, and aspects of the social or ecological environment. Over all these patients show relatively optimistic prospects to their own future.

Adaptation, Psychological↗
PubMed1984

Cortical subacute necrotizing encephalomyelopathy. A study of two patients with mitochondrial dysfunction.

Two patients are reported who presented with progressive impairment of neurological and intellectual function, and intractable fits. In both the disease ran a fluctuating course. There was evidence of mitochondrial dysfunction, serum levels of pyruvate and lactate being four to six times normal. Involvement of mitochondria in different organs was suggested by histochemical and ultrastructural investigations of muscle and heart tissue. The children died at nine years and twelve months, respectively. In both autopsy revealed cardiomyopathy and renal abnormalities. The brain showed severe lesions indistinguishable from subacute necrotizing encephalomyelopathy (SNE), the brunt of which was borne by the cortex.

Cerebral Cortex↗
PubMed1984

The coping process with illness in patients with cardiovascular or cerebrovascular diseases: a new survey: EKV.

The EKV is a survey constructed by the authors to get detailed information about the patient's feelings, thoughts, attitudes, and plans when confronted with a severe organic (chronic) disease, especially with cardiovascular or cerebrovascular diseases. Starting from the actual situation the focus lies on the patient's realization of consequences resulting from the illness-event for the organic, emotional-cognitive, familial, occupational and social aspects of life. Further topics are early and previous events or thoughts and the development of symptoms associated with the later outbreak of functional disorders or organic lesions which are treated now. Attention is also paid for the treatment situation in the past and at time and for the patient's projections to future life: thoughts about the progress of his disease, expected physical and psychical potency, occupational and leisure plans, partnership, familial and social life, illness-related changes in the style of life, expected satisfaction with life etc. The survey is to be used as a half-structured interview that takes 2 to 3 hours. It has already been tested, modified and now used on ca. 150 patients with different vascular diseases (pts. with myocardial infarction, coronary heart disease (angina pectoris), functional heart and circulatory disorders; completed stroke, prolonged ischaemic neurological defect, or transitoric investigation with the EKV are in preparation. Within a psychosomatic framework the survey gives a relevant overview and useful insight in the patient's reality, his adapting and coping reactions, the meaning of the chronic disease for his self-conception and way of life, as well as possibilities or necessities for psychological interventions and other treatment aspects.

Adaptation, Psychological↗
PubMed1983

Is migraine food allergy? A double-blind controlled trial of oligoantigenic diet treatment.

93% of 88 children with severe frequent migraine recovered on oligoantigenic diets; the causative foods were identified by sequential reintroduction, and the role of the foods provoking migraine was established by a double-blind controlled trial in 40 of the children. Most patients responded to several foods. Many foods were involved, suggesting an allergic rather than an idiosyncratic (metabolic) pathogenesis. Associated symptoms which improved in addition to headache included abdominal pain, behaviour disorder, fits, asthma, and eczema. In most of the patients in whom migraine was provoked by non-specific factors, such as blows to the head, exercise, and flashing lights, this provocation no longer occurred while they were on the diet.

Abdomen↗
PubMed1983

Mitochondrial inheritance in a mitochondrially mediated disease.

Mendelian inheritance involves the transmission to successive generations of DNA contained in genes in the nucleus, but DNA is also contained in mitochondria, where it is believed to be responsible for the encoding of certain mitochondrial enzymes. Since nearly all mitochondrial DNA is maternally transmitted, one might expect a nonmendelian pattern of inheritance in mitochondrial cytopathy, a syndrome in which there are abnormalities in mitochondrial structure and deficiencies in a variety of mitochondrial enzymes. We studied the pedigrees of 6 affected families whose members we had examined personally and of 24 families described in the literature. In 27 families, exclusively maternal transmission occurred; in 3 there was also paternal transmission in one generation. Altogether, 51 mothers but only 3 fathers had transmitted the condition. These results are consistent with mitochondrial transmission of mitochondrial cytopathy; the inheritance and enzyme defects of mitochondrial cytopathy can be considered in the light of recent evidence that subunits of respiratory-enzyme complexes are encoded solely by mitochondrial DNA. The occasional paternal transmission may be explained if certain enzyme subunits that are encoded by nuclear DNA are affected.

DNA, Mitochondrial↗
PubMed1983

Involvement of the central nervous system in congenital muscular dystrophies.

Three children, two siblings and one unrelated child, with congenital muscular dystrophy with central nervous system (CNS) involvement are discussed. The siblings appeared to suffer from a relatively mild myopathy with progressive brain disease, of which brain biopsy in one showed astrocytic proliferation in the white matter. In the patient with severe muscle disease, autopsy showed widespread patchy demyelination in the white matter and developmental abnormalities in the cerebral and cerebellar cortex. These patients differ from the Japanese (Fukuyama) cases of CMD in the severity of the changes in the cerebral white matter, and from Santavuori's cases in the absence of ocular abnormalities and hydrocephalus. Their unique nosology is discussed.

Adolescent↗
PubMed1983

[Age-dependent adjustment to disease in patients with cardiovascular diseases].

During their rehabilitation treatment 61 inpatients with different cardiovascular diseases or disorders were investigated with structured interviews, questionnaires about anamnesis and psychological tests in order to determine the individual coping strategies. The mean results show that three of four pts with functional heart and circulatory disorders don't know anything or something wrong about the pathology of their symptoms. Pts with coronary heart disease without myocardial infarction don't have any or any right information in 45%, but coronary infarction-pts don't have any right pathogenetic knowledge in only 12% (differences: p less than .05). The pathogenetic knowledge is not statistically correlated with the age of the pts. In total 54% can't give any reasons for the incidence, 18% are accusing their own health behaviour, 15% say that it is fate and 13% are believing that primarily environmental factors are the best conception about the etiology of their disease. The subjective illness-related psycho-physical irritation show a moderate to average strength and does not depend on pts' age. The main actual cognitive and emotional reaction to illness is in 40% denial, 30% are trying to adept actively to the given situation, 22% show acute mourning and anxiety and 8% respond with rebellion, aggressiveness or anger (differences: p less than .01). There is a tendency growing with increasing life-age to accept the event of illness as a chance for an active change to a better style of life in future. Pts with cardiovascular diseases design an overall optimistic development for their own future: they expect an age of 66.2 years, male pts believe to grow older than female (p less than .01). The prospected satisfaction with life doesn't show any significant differences depending on diagnosis or age. All in all the results lead to the conclusion that the factor "age of life" does not play a dominant role in the process of managing with cardiovascular diseases compared with psychological factors of coping with the illness.

Adaptation, Psychological↗
PubMed1982

[Sex function disorders after myocardial infarct. Diagnosis, counseling and therapy].

Sexual activities are possible and important even after myocardial infarction. Sexual complaints after a coronary heart disease are frequent, in most cases functional and primarily caused by psychological or psychosocial problems. There are good reasons to provide for psychological counselling and short-time therapy of sexual disturbances in the postcoronary rehabilitation programme. Beside clarifying the organic situation (physical load capacity, length of the interval after myocardial infarction, genitovascular insufficiency, medication etc.), the hormonal and functional situation, it is necessary to pay particular attention to a sufficient counselling and psychic management of the patient's sexual problems (fear of the dangers of overexertion, depression, fear of failure, the undigested change of familial and occupational status etc.). It is shown that these demands may be taken into account in multidimensional therapeutic work which has been performed in a special rehabilitation centre treating patients suffering from heart and circulatory diseases.

Female↗
PubMed1982

Mitochondrial cytopathy or Leigh's syndrome? Mitochondrial abnormalities in Spongiform encephalopathies.

A boy with mitochondrial cytopathy and neuropathological changes of subacute necrotizing encephalopathy is reported. Conditions with abnormal mitochondria in muscle and/or brain are reviewed and the role of mitochondrial abnormalities in spongiform encephalopathies is discussed. It is suggested that electronmicroscopical and histochemical investigations of muscle tissue would be of value in patients with Leigh's syndrome or other forms of spongiform encephalopathies.

Brain↗
PubMed1982

Joubert-Boltshauser syndrome with polydactyly in siblings.

Two siblings are described with clinical features of the Joubert-Boltshauser syndrome. Both had polydactyly and one had fleshy tumours of the tongue. Computed tomography of the brain showed hypoplasia of the cerebellar vermis, associated in one case with a cyst of the fourth ventricle.

Apnea↗