Search PubMedSearch

Biomedical subjects

J Egawa

Publications and source records attributed to J Egawa.

At least 19 recordsLinked to original sources

[Effect of porcine calcitonin on pain caused by cancer-induced bone destruction].

The analgesic effect of porcine calcitonin (PCT) was studied in 32 patients with cancer-induced bone destruction. Twenty patients (62.5%) showed some response among them 10 of 13 patients who had suffered from uncontrollable pain despite other treatment methods such as radiotherapy, and or the administration of other analgesics. The effect was observed about 10 days after the administration of the drug. Combined therapy with PCT and other modalities such as radiotherapy, chemotherapy and hormone therapy had a marked effect in controlling the pain.

Adolescent

[Fundamental and clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology].

T-1982 (cefbuperazone), a new cephamycin antibiotic, was fundamentally and clinically studied in the field of obstetrics and gynecology. The following results were obtained. The concentrations of T-1982 in arterial and venous blood and genitalia following intravenous injection were measured. The results demonstrated favourable transfer of the drug into various internal genital organs. T-1982 was administered to 12 patients. The efficacy rate was 75.0%, that is to say, good in 9 cases. No side effects were noted in any cases. It is, therefore, presumed that T-1982 is a useful drug for the infectious diseases in the field of obstetrics and gynecology although the number of subjects was not so large in this study.

Adult

[Clinical trial of cancer therapy by radiation combined with hyperthermia].

A clinical trial of radiation therapy combined with hyperthermia for various superficial tumors was performed. For the local hyperthermia, heating modalities with microwave, radiofrequency and ultrasound can be used. Some are still insufficient for clinical application in terms of tumor size and site; there fore, for ther studies through a phase II study are necessary to determine a future direction of hyperthermia in clinical case.

Female

[Heat therapy].

Applications of hyperthermia in cancer therapy is now widely studied. Appropriate apparatus for the tumors with various size and positions should be developed. We are developing a system with 2450 MHz microwave and constructed several applicators for the surface tumors and intracavitary tumors. Those were already used in human tumors. Capacitive heating with RF were used for the combined therapy with radiation in Kyoto University. More than 50% of the treated cases were responded well resulting complete regression of tumors. Experimental system of heating with magnetic induction is now studied.

Aged

Radiation effects on the fine blood vessels in abdominal organs of mice.

The capillary networks of normal and irradiated abdominal organs of mouse were investigated by a resin cast technique. The structure of the capillary system had characteristic appearances. Radiation effects on the fine vascular structures were demonstrated from one appearances. Radiation effects on the fine vascular structures were demonstrated from one to 30 days after a single dose of 5 to 30 Gy whole body irradiation. Prominent morphologic abnormalities of the shape and distribution of the capillaries were identified, especially in the small intestine.

Abdomen