Biomedical subjects
Publications and source records attributed to J Edmonds.
Proteolysis, as measured by tyrosine release, was estimated in abdominal and diaphragm muscle of hamsters. There did not appear to be a difference between dystrophic and control hamsters.
The spectrum of organ involvement in 50 patients with systemic lupus erythematosus has been assessed in a prospective study. All patients were admitted to hospital electively for 2 days and a complete clinical and laboratory assessment protocol completed. Subsequent hospital admissions depended on clinical status. The overall mean observation period was 29 months. Widespread multisystem involvement was found in every patient. Subclinical abnormalities of respiratory and cerebral function were common even in patients in clinical remission. A more conservative approach than has been generally recommended was used for the management of systemic lupus erythematosus and is supported by the estimated 5-year survival of 98%.
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The effects of neurotrophic factors on muscle protein degradation in rat leg muscle were studied. In order to inhibit axoplasmic transport and therefore transport of "trophic" factors, the colchicine cuff method of Albuquerque et. al. (1972) was modified so that the cuffs were cast in situ. Protein degradation was estimated by monitoring the release of tyrosine from the muscle. Our observations that colchicine cuffs increased tyrosine release are consistent with the concept of nerve-muscle trophism.
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Neonatal follow-up studies of school age children, published in the last decade, were critically reviewed. Nine studies examined extremely low birthweight infants (less than or equal to 1000 g) and 16 involved very low birthweight infants (less than or equal to 1500 g). The majority of children had age appropriate I.Q. scores, however, there was a greater variability of test scores. There was an increased need for special education or remedial therapy. Visual-motor integration deficits were frequently reported. Behavioural difficulties were described. Fine and gross motor incoordination was identified. There was no conclusive correlation between perinatal course and school outcome. Gender did appear to influence outcome, in the small percent of studies which examined this variable, with females generally faring better. Low socioeconomic status was the most frequently reported predictor of poor outcome. Identified methodological limitations included heterogeneous samples, lack of control groups, high attrition, variable diagnostic criteria and lack of consensus regarding correction for prematurity.
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