Central on-site preparation of substitution fluid for hemofiltration.
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Blood↗
Biomedical subjects
J Ebben
Publications and source records attributed to J Ebben.
Three hollow fiber dialyzers.
Hollow fiber dialyzers with a variety of sizes and performance characteristics are presently available for the dialysis of adult patients. We evaluated three currently available follow fiber adult dialyzers in vitro and in vivo during treatment of adult patients. All three dialyzers, Gambro GF-120H, Gambro GF-120L, and Travenol CF-1211 were well suited for the dialysis of adult patients. By considering the clinical status of the patients and the performance characteristics of the dialyzer (solute removal, ultrafiltration, priming volume, etc.), it is possible to employ the follow fiber dialyzer which most precisely meets the needs of the patient, without increasing risk factors associated with hemodialysis.
Adult↗
Time of death, recovery of renal function, development of chronic renal failure and need for chronic hemodialysis in patients with acute tubular necrosis.
We analyzed 432 patients with acute tubular necrosis, dialyzed at the University of Minnesota Dialysis Unit between 1968-1979. Only 135 patients or 31% survived. The median time to death was 5 days and to recovery of renal function was 12 days. Serum creatinine continued to fall for one month after the last dialysis and then stabilized. Ultimate serum creatinine level was directly related to age of patient but not duration of need for dialysis. One-fourth of the patients were left with moderate renal insufficiency (creatinine 1.5-3 mg/dl). Eight of 82 (10%) of the patients with long term (greater than 1 mo follow-up) had severe renal failure (creatinine over 3 mg/dl) and 4 other patients never recovered renal function but needed chronic hemodialysis. Acute renal failure is numerically important but not very time demanding on the capacity of dialysis units. The majority of the patients have no clinical problem of renal dysfunction if they survive their basic disease leading to acute tubular necrosis.
Acute Kidney Injury↗
Techniques for use of charcoal hemoperfusion in infants: experience in two patients.
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Charcoal↗
Four new dialyzers.
Dialyzers with a variety of sizes and performance characteristics are presently available for the dialysis of adult patients. We evaluated four currently available disposable adult dialyzers in vitro and in vivo during treatment of adult patients. All four dialyzers, Gambro GLP 1.36m2, 17 mu, Cordis Dow 3500, Gambro GF 120M, and Travenol HD 1000 were well suited to the dialysis of adult patients. By considering the clinical status of the patients and the performance characteristics of the dialyzer (solute removal, priming volume, ultrafiltration, etc.) it is possible to employ a hemodialyzer which more precisely meets the needs of the patient without increasing risk factors associated with hemodialysis.
Arteries↗
Evaluation of three dry-sterilized hollow fiber artifical kidneys.
We investigated three new dry sterilized hollow fiber artificial kidneys (HFAK) (Cordis Dow CDAK 1.3, Travenol CF 1200, Extracorporeal Tri-Ex 1). Dry sterilization makes these dialyzers more economical by shortening set-up time. Dry sterilization also eliminates iatrogenic administration of residual sterilant. Water of imbibition can significantly increase the blood compartment volume of the dialyzer during dialysis. Consequently, a corrected blood volume for each dialyzer was established; these corrected volumes varied from 13--36% greater than the volume determined before dialysate flow. With low dose heparinization of these dialyzers there was between an 18 and 45% decrease in the post dialysis volume, presumably due to fiber clotting during dialysis. This volume added to the residual blood loss measured by a colorimetric technique accounted for a possible blood loss ranging between 26.9 and 53.9 ml per dialysis for these three dialyzers. Our results suggest that a relationship between dialyzer clotting and decreased dialyzer efficiency may exist. These three capillary flow dialyzers had a much lower platelet drop (0--9% pre to post) when compared to 30--40% drop of flat plate dialyzers. These dialyzers were found to be safe and easy to use but the high fiber clotting warrants further investigation in chronic dialysis patients on high dose heparin.
Kidneys, Artificial↗