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J E Richardson

Publications and source records attributed to J E Richardson.

At least 19 recordsLinked to original sources
PubMed1999

GXD: a gene expression database for the laboratory mouse. The Gene Expression Database Group.

The Gene Expression Database (GXD) is a community resource that stores and integrates expression information for the laboratory mouse, with a particular emphasis on mouse development, and makes these data freely available in formats appropriate for comprehensive analysis. GXD is implemented as a relational database and integrated with the Mouse Genome Database (MGD) to enable global analysis of genotype, expression and phenotype information. Interconnections with sequence databases and with databases from other species further extend GXD's utility for the analysis of gene expression data. GXD is available through the Mouse Genome Informatics Web Site at http://www.informatics.jax.org/

Animals↗
PubMed1999

The Mouse Genome Database (MGD): genetic and genomic information about the laboratory mouse. The Mouse Genome Database Group.

The Mouse Genome Database (MGD) focuses on the integration of mapping, homology, polymorphism and molecular data about the laboratory mouse. Detailed descriptions of genes including their chromosomal location, gene function, disease associations, mutant phenotypes, molecular polymorphisms and links to representative sequences including ESTs are integrated within MGD. The association of information from experiment to gene to genome requires careful coordination and implementation of standardized vocabularies, unique nomenclature constructions, and detailed information derived from multiple sources. This information is linked to other public databases that focus on additional information such as expression patterns, sequences, bibliographic details and large mapping panel data. Scientists participate in the curation of MGD data by generating the Chromosome Committee Reports, consulting on gene family nomenclature revisions, and providing descriptions of mouse strain characteristics and of new mutant phenotypes. MGD is accessible at http://www.informatics.jax.org

Animals↗
PubMed1998

The Mouse Genome Database (MGD): a community resource. Status and enhancements. The Mouse Genome Informatics Group.

The Mouse Genome Database (MGD) is a comprehensive community database that integrates genetic, genomic and phenotypic information about the laboratory mouse. MGD provides detailed information about genes and genetic markers, elemental data from mapping experiments, descriptions of molecular segments including ESTs, probes, and cDNA clones, homology information between mouse and many other mammalian genomes, and phenotypic descriptions of gene mutations, gene function and mouse strains. All data are supported by citations. Interactive graphical displays of cytogenetic, genetic and physical maps are available. User support is provided through dedicated staff, bulletin boards, and user documentation. MGD can be accessed at http://www.informatics.jax.org

Animals↗
PubMed1998

Informatics for mouse genetics and genome mapping.

Bioinformatics has become an essential part of biological research. The rapid pace of technology development and the ability to carry out biological experimentation in large scale require computerized systems for data management, analysis, and display. Experimentation with the mouse, a major model organism of the Human Genome Initiative, has intensified the need for bioinformatics tools for mouse mapping and genome analysis. This article describes the Mouse Genome Database in the United States, a primary resource for mouse genomic data, as well as resources at the Mammalian Genetics Unit in the United Kingdom and the Animal Genome Database of Japan. Internet addresses are provided for major genetic and physical mapping resources, major genome data sites, and resources of molecular information.

Animals↗
PubMed1997

The Mouse Genome Database (MGD). A comprehensive public resource of genetic, phenotypic and genomic data. The Mouse Genome Informatics Group.

The Mouse Genome Database (MGD) is a comprehensive community resource of mouse genetic and biological information populated both with data from published literature and with data electronically submitted from the research community. MGD stores genetic, physical and comparative mapping data, clones/probes/PCR information, and phenotype descriptions for genes, mutations and mouse strains. Supporting software for importation, analysis, display and distribution of mouse genetic data have been developed. User support is provided through dedicated staff providing documentation, training, and response to individual user queries. MGD is accessible over the Internet at URL http://www.informatics.jax.org.

Animals↗
PubMed1995

A Rosetta stone of mammalian genetics.

The Mammalian Comparative Database provides genetic maps of mammalian species. Comparative maps are valuable aids for predicting linkages, developing animal models and studying genome organization and evolution.

Animals↗
PubMed1990

A study of a work site health promotion program and absenteeism.

This paper reports on a study of the absenteeism experience of two groups of Johnson & Johnson employees over a 3-year period. Employees at four company sites (n = 1406) where LIVE FOR LIFE, a comprehensive health promotion program, had been introduced, were compared with employees at five company sites (n = 487) without the health promotion program. Analyses of covariance were employed to control for differences between the two study groups with respect to age, gender, job classification (wage or salaried), as well as baseline levels of absenteeism. Adjusted mean levels of absenteeism among wage earners in the LIVE FOR LIFE groups were found to decline over the study period, and were significantly lower (P less than .01) than mean levels for the non-LIVE FOR LIFE wage employees in the final year of the study. No significant differences were found for salaried personnel.

Absenteeism↗
PubMed1988

The incidence of childhood diabetes in certain parts of Scotland.

The incidence of diabetes in children under 12 years of age has been studied in three regions of Scotland from 1976 to 1986. These areas represent more than half of the Scottish population of that age group. The overall annual incidence is 17.6 per 100,000, ranging from 16.8 in densely populated areas to 23.4 in more rural areas. Earlier studies have concerned the age group 0-18 years so the present results from a younger age group are, as expected, slightly lower but show the same trends. After a rise to 1983 there appears to have been a drop, but not in all areas. The danger of drawing conclusions from areas of low population or from short periods of time is stressed.

Adolescent↗
PubMed1988

Traumatic wound of the heart: value of intraoperative colour Doppler flow imaging.

A patient who sustained a traumatic ventricular septal defect from a stab wound is presented. Intraoperative echo-Doppler imaging provided an additional diagnosis of avulsion of anterior papillary muscle of the tricuspid valve prior to cardiotomy. It was concluded that intraoperative echo-Doppler imaging proves a useful guide for cardiac surgery following penetrating trauma.

Adult↗
PubMed1987

HLA-DR4 in giant cell arteritis: association with polymyalgia rheumatica syndrome.

Forty-three patients with well-documented giant cell arteritis (GCA) were studied clinically and with HLA typing. All patients were over age 40. Twenty-two of the patients had coexistent polymyalgia rheumatica (PMR). No association with class I HLA antigens was detected. When compared with HLA findings in 243 healthy controls, HLA-DR4 was increased in patients with GCA and PMR, but not in patients with GCA alone. Pooled analysis of data from 4 published papers confirmed the association of DR4 with GCA and PMR (P much less than 0.00001). Patients with PMR but negative findings of temporal artery biopsies also showed an increased frequency of HLA-DR4, but this did not reach statistical significance, probably because of the small number of subjects. It is likely that the increased frequency of DR4 in GCA patients is related to its association with PMR.

Adult↗
PubMed1986

Impact of worksite health promotion on health care costs and utilization. Evaluation of Johnson & Johnson's Live for Life program.

This study explores the relationship between exposure to a comprehensive worksite health promotion program and health care costs and utilization. The experience of two groups of Johnson & Johnson employees (N = 5192 and N = 3259) exposed to Live for Life, a comprehensive program of health screens, life-style improvement programs, and worksite changes to support healthier life-styles, was compared with that of a control group (N = 2955) over a five-year period. To account for baseline differences, analyses of covariance produced adjusted means for inpatient hospital costs, admissions, hospital days, outpatient costs, and other health costs. Mean annual inpatient cost increases were $43 and $42 for two Live for Life groups vs $76 for the non-Live for Life group. Live for Life groups also had lower rates of increase in hospital days and admissions. No significant differences were found for outpatient or other health care costs.

Costs and Cost Analysis↗
PubMed1986

Lymphocytotoxins in vasculitis. Correlation with clinical manifestations and laboratory variables.

Twenty-eight of 53 patients with various types of vasculitis were found to have cold reacting lymphocytotoxins (LCT). LCT were cytotoxic to both peripheral blood B and T cells as well as to OKT4 and OKT8 subpopulations. The interaction with the B cells was more pronounced than with the T cells as shown by reactivity with the former at higher serum dilutions than with the latter. Similar results were obtained with eluates from the unseparated lymphocytes and from B or from T cells. Partial purification of LCT demonstrated that they belong to the IgM class. LCT correlated with the level of circulating immune complexes as determined by the fluid phase C1q binding assay, but they did not correlate with the level of immunoglobulins, complement or antinuclear factors. The presence of LCT correlated significantly with the activity but not with the disease duration or the number of involved organs. Correlation of LCT with the activity of vasculitis implies that these cytotoxins may have a pathogenetic role and perhaps may serve as a marker for disease activity.

Antigen-Antibody Complex↗
PubMed1985

The nutritional status and feeding practices among sick urban pre-school children admitted to a major hospital in Accra, Ghana.

In a prospective study of 652 sick pre-school children only 33% were found to be adequately nourished. Among the malnourished, 54.3% had first degree malnutrition while 32.3% and 13.4% had second and third degree malnutrition respectively. The majority of malnourished children (72.4%) had undernutrition: kwashiorkor (14.2%), marasmus 7.3%) and marasmic kwashiorkor (6.1%) was relatively less common. Furthermore, 58% of the underweight children were stunted, indicating malnutrition of some considerable duration. Malnutrition was essentially of postnatal origin and closely related to a high incidence of malnutrition-associated illnesses: diarrhoea (74%), measles (51%) and intestinal parasites (54%). Though breast feeding was universal and of adequate duration, milk production was mostly inadequate because of too early supplementation with low-energy cereal gruels with little or no protein-enrichment. The majority of children came from low socio-economic homes (61%) with mostly illiterate or semi-literate mothers. It is essential that newer methods of teaching be employed in the health education of these unfortunate mothers. Health institutions other than well-baby clinics need to have integrated units for nutritional and immunization surveillance and also for serving as avenues for the supply of free supplementary food items to children with poor weight gain, especially those from poor homes. Clinical Nutrition Units are needed to ensure that inpatients receive nutrients sufficient for continuing and catch-up growth.

Adult↗
PubMed1984

Measles in Ghana--1973-1982.

Admissions of children with measles constituted 8.8% of all admissions to the paediatric medical service of the Korle Bu Teaching Hospital, Accra, over the ten-year-period 1973-1982. Measles remains endemic in urban Accra as in the towns of other developing nations. The peak of admissions occurred in the age range seven to 12 months. Complications were frequent, with a high mortality (16.86%). Bronchopneumonia, the commonest complication (63.9%) was also the commonest cause of death in 51.5% of cases. Comparative national case-mortality rates were, however, surprisingly low and should be accepted with caution. There is an urgent need for intensification of immunization efforts through amalgamation of the preventive and curative services of Ghana, especially for children attending health centres for medical care. Vaccination should be administered before the peak age of admission, preferably at six months of age, with a second dose administered as soon after one year of age as possible.

Age Factors↗