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Biomedical subjects

J E Pohl

Publications and source records attributed to J E Pohl.

49 records · Page 3Linked to original sources
PubMed1972

Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.

Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia. Two were insulin-dependent diabetics and one of these suffered from renal failure. In all patients albuminuria diminished markedly, while the fluid retention was controlled with frusemide. Three pregnancies were successfully terminated by lower segment caesarean section and in the remaining case vaginal delivery resulted in the birth of a healthy baby. Control of blood sugars presented no problems in the diabetic patients. Only minimal adjustments of insulin dosage were required. One of the non-diabetic patients developed mild hyperglycaemia which responded to tolbutamide. The babies, ranging in age from 5 to 12 months, have continued to thrive.

Acute Disease↗
PubMed1972

Impairment of cognitive function associated with hydroxyamylobarbitone accumulation in patients with renal insufficiency.

1. Sodium amylobarbitone was given by intravenous infusion to six patients with chronic renal insufficiency and to six healthy volunteer subjects. Serum concentrations of amylobarbitone and its major metabolite hydroxyamylobarbitone were measured by a gas chromatograph method.2. The serum concentrations of amylobarbitone were consistently lower in the patient group than in the control group and the concentration half time was shorter (0.10>P>0.05); the 48 h urinary excretion of hydroxyamylobarbitone was reduced (P<0.001) and the serum concentrations of hydroxyamylobarbitone were consistently raised.3. When two patients were given 200 mg of sodium amylobarbitone daily over five consecutive days the serum concentration of hydroxyamylobarbitone rose steadily to a maximum of about 8 mug/ml. The serum concentrations in two healthy control subjects did not exceed 0.5 mug/ml.4. Three parallel tests of cognitive function (Otis matched test forms A, B and C) were given to 16 control patients and to 12 amylobarbitone-treated patients. Significant impairment of performance was observed in test B (P<0.001) at a time when amylobarbitone only could be detected in the patients' serum, and in test C (P<0.001) when amylobarbitone concentrations were very low (0.52+/-0.08 mug/ml+/-SEM) but hydroxyamylobarbitone concentrations were still high (3.30+/-1.23, mug/ml+/-SEM).5. There was a strong (r=-0.71) and significant (P<0.01) negative correlation between the performance in test C and the serum concentration of hydroxyamylobarbitone. It is concluded that hydroxyamylobarbitone has cerebral depressant effects in man.

Adult↗
PubMed1971

Use of diazoxide in hypertension with renal failure.

Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment. Rapid initial and good long-term control of hypertension was achieved in all cases without the production of clinically significant postural hypotension. The side effects of diazoxide, including its diabetogenic effect, were easily controlled. There was a highly significant improvement in renal function in most patients on long-term oral diazoxide therapy.Diazoxide may have an important place in both the short- and long-term therapy of resistant hypertension, particularly in association with renal damage.

Adolescent↗
PubMedDate not supplied

Myocardial infarction and thrombolysis: a comparison of the Indian and European populations on a coronary care unit.

We reviewed the ward admission notes of 211 Indian and 192 European patients admitted over a period of 12 months to a coronary care unit. More Indian patients had myocardial infarctions (34% vs 27%, p < 0.05); they were more likely to have diabetes mellitus (47% vs 14%, p < 0.001), but less likely to smoke (19% vs 67%, p < 0.001). Fewer Indian patients were treated with thrombolysis (49% vs 80%, p < 0.001), late presentation being the principal reason (62% vs 40%, p < 0.05). The referral rates for exercise stress testing and cardiac catheterisation were not significantly lower for Indian patients. The Indian patient admitted into a coronary care unit is more likely to have had a myocardial infarction and yet less likely to receive care comparable to that of his European counterpart.

Adult↗