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Biomedical subjects

J E Olson

Publications and source records attributed to J E Olson.

107 records · Page 6Linked to original sources
PubMed1980

Persistent hoarseness: an aggressive approach for early detection of laryngeal cancer.

Persistent hoarseness in a patient should always alert the physician to the possibility of laryngeal carcinoma. Prompt visualization of the larynx is essential, particularly in high-risk patients over 40 years of age without a history of upper respiratory infection. Mirror examination (indirect laryngoscopy) is the usual initial diagnostic procedure, although Hopkins' rod telescope and the fiberoptic laryngoscope may provide more adequate visualization. Direct laryngoscopy and biopsy allow definitive diagnosis.

Adult↗
PubMed1979

Low-frequency harmonic acceleration in the evaluation of surgical treatment of Meniere's disease.

23 patients with classical findings of Meniere's disease and so diagnosed by a neurotologist were tested with harmonic acceleration. 7 of these patients were selected to receive endolymphatic-mastoid shunts for intractable vertigo and/or highly progressive fluctuant hearing loss. All 7 patients showed an increase in the impairment in their phase relationships at the lowest frequency (0.01Hz) following surgery which was considered to be secondary to the procedure. Later this phase lag returned to a level approaching normal. They also showed a definite decrease in the asymmetry (labyrinthine preponderance) of their nystagmic responses to acceleration.

Acceleration↗
PubMed1979

The use of glucagon in operative cholangiography.

We have found intravenously administered glucagon to be useful in relaxing the sphincter of Oddi during operative cholangiography. It is readily available, has few potential side-effects, is easily administered intraoperatively and has been promptly and reliably effective.

Adult↗
PubMed1978

Lipomas of the internal auditory canal.

We present two cases of lipoma of the cerebellopontine angle (CPA), which brings, to our knowledge, the total reported in the literature to six. These cases had a clinical, surgical, and postoperative course that was similar to a small acoustic neuroma. The roentgenographic aspects were in keeping with small, CPA tumors. A review of the literature of CPA tumors and lipomas of the CNS is presented. We discuss the controversy surrounding the origin of lipomas of the CNS.

Adult↗
PubMedDate not supplied

Hyperthermia-induced seizures in rat pups with preexisting ischemic brain injury.

To investigate the mechanism(s) relating perinatal brain injury to increased seizure sensitivity in the developmental age period, we studied hyperthermia-induced seizures in rat pups with a preexisting unilateral ischemic cerebral injury. At 2 days of age, the pups underwent a carotid artery ligation followed by 20 min of anoxia. By light microscopy, there were no pathologic changes in the postischemic cerebral cortex at 5, 10, or 20 days of age. Seizures were induced by hyperthermia at 5, 10, 15, or 20 days of age. Seizure temperature thresholds increased with maturation in both postischemic and control animals. Temperature thresholds for behavioral seizures were significantly lower at 10, 15, and 20 days in postischemic pups, compared with control animals. By EEG criteria, seizure thresholds also were lower at 10 and 15 days in the postischemic pups compared with control animals. Preictal EEG slowing appeared at the same temperature in experimental and control animals at all ages. We conclude that the rat pup is an appropriate model for the study of enhanced epileptogenesis in the presence of a perinatal ischemic encephalopathy.

Animals↗
PubMedDate not supplied

Comparison of subjective symptomatology and responses to harmonic acceleration in patients with Menière's disease.

Vestibular function testing employing caloric stimulation has been of limited value in the evaluation of patients with Menière's disease, with its cardinal shortcoming being poor repeatability. This modality has not been useful in determining appropriate treatment for these individuals. We have used low frequency harmonic acceleration to study patients with vestibular pathology and have noted a high level of repeatability of responses to this type of stimulation. This study was designed to determine if the clinical status of patients with Menière's disease could be correlated with their responses to harmonic acceleration. Thirty-six patients with typical symptoms of Menière's disease were evaluated and divided into four groups based on severity of symptoms. Analysis of variance of the phase shifts in asymmetry (or preponderance) showed a significant difference between the groups. Responses to this type of stimulation correlated with the clinical status of the patients to a significant degree. These data indicate that harmonic acceleration can be of value to the otologist in the evaluation of patients with Menière's disease.

Adult↗
PubMedDate not supplied

Osteomalacia and weakness complicating jejunoileal bypass.

Five years following jejunoileal intestinal bypass surgery for obesity, a patient developed debilitating weakness and muscle pain. Osteomalacia was suspected clinically by radiographic and laboratory abnormalities and confirmed by bone biopsy. Malabsorption was documented as well as secondary hyperparathyroidism. Successful treatment of this syndrome with vitamin D and calcium identified a medically reversible disorder which obviated the need for surgical reanastomosis.

Adult↗