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Biomedical subjects

J E Morgan

Publications and source records attributed to J E Morgan.

At least 181 records · Page 10Linked to original sources
PubMed1978

Enhancement by hyperthermia of the effect of BCNU against the EMT6 mouse tumor.

The combination of moderate hyperthermia (43 degrees C water bath for 1 hour) and BCNU against the EMT6 mouse tumor has been studied. The effect was found to be much greater than could have been predicted from the effects of the single modalities and this is true whether the endpoint is tumor cure, growth delay, or in vitro assay of clonogenic fraction. The results indicate that inhibition of "recovery from potentially lethal drug damage" is not the mechanism by which heating potentiates the action of BCNU.

Animals↗
PubMed1977

Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07-0582 on the EMT6 mouse tumour.

The combination of hyperthermia and the hypoxic cell radiosensitizer Ro-07-0582 has been investigated on the EMT6 tumour implanted into the legs of BALB/c mice. Treatments at a drug dose of 1 mg/g over a range of waterbath temperatures from 37 to 45 degrees C are described. The surviving clonogenic fraction following treatment was assayed in vitro. Measurements of intra-tumour temperature have been made, and shown to be better correlated with the cytocidal effect on the tumour than the waterbath temperature. No significant effect of Ro-07-0582 was observed at 37 degrees C. However, marked cytotoxicity due to the drug was seen at intra-tumour temperatures above 42-5 degrees C for 1 h. These were in addition to the cytocidal effect of the hyperthermia. The results are discussed in relation to the distribution of temperatures and hypoxic cell populations throughout the tumour.

Animals↗
PubMed1977

Recurrent stress urinary incontinence in the female.

1,500 females presenting with recurrent urinary incontinence were investigated in depth. 27% required further surgery, 127 of whom were treated with a 2-team Marlex sling. Careful assessment is the key to treatment including cystoscopy and good radiological documentation. One must be aware of the capabilities and limitations of the various procedures employed for stress incontinence and select the correct procedure for the given problem. When dealing with recurrent stress incontinence the surgical procedure must take down all periurethral scar, anteriorly and posteriorly and adequately elevate the urethrovesical junction so it is not the dependent point at the base of the funnel. The Marlex sling procedure fulfills the above criteria, has been singularly effective, and remarkably free of complications.

Cystoscopy↗
PubMed1977

Liver biopsy in hemophilia A.

Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia A who had the persistence of abnormal liver-function tests for at least 6 months, are described. Three patients had chronic active hepatitis, and three had chronic persistent hepatitis. No complications were encountered as a result of the biopsy procedure. These results suggest that percutaneous liver biopsy should be considered in patients with hemophilia A with continuously abnormal liver-function tests to establish a histologic diagnosis and to guide further therapy.

Acute Disease↗
PubMed1977

Risk factors and early diagnosis in pancreatic carcinoma.

A case is reported of pancreatic carcinoma recognized four years after bile peritonitis complicated cholecystectomy. The patient possessed all the known significant risk factors associated with pancreatic carcinoma. The wider recognition of risk factors for pancreatic adenocarcinoma might lead to closer follow-up of patients with multiple factors and possible earlier diagnosis and treatment leading to increased survival in patients with the disease.

Adenocarcinoma↗
PubMed1976

Total pancreatectomy for recurrent medullary fat necrosis.

A patient had subcutaneous and medullary bone fat necrosis associated with chronic, recurrent pancreatitis. In the case, recurrent symptoms of pancreatitis as well as progressive bone destruction were correlated with an increase in serum lipase levels. Total pancreatectomy was followed by relief of all symptoms and healing of destroyed bone. Medullary fat necrosis may be associated with pancreatitis, pancreatic trauma, or cancer of the pancreas. Pancreatectomy may be useful if conservative treatment does not lead to healing of severe medullary fat necrosis associated with recurrent pancreatitis.

Chronic Disease↗
PubMed1976

A rocking motion sensor for the blind.

Rocking motion is an unconscious and often unwanted phenomenon exhibited by the blind. It is usually manifested in oscillatory back and forth, side to side, or rotatory movements of the upper torso or head at about 1 Hz rate. Subjects desiring to function unobtrusively in the world of the sighted need to be alerted when rocking so they can control it. The rocking motion sensor incorporates biofeedback and records rock occurrences. A miniature body mounted accelerometer senses body accelerations exceeding 0.1g. These motions during a given period, compared with a presettable "rock threshold", discriminate rocking from normal activities. Sound biofeedback alerts the subject that he has exceeded threshold. Another counting and timing subsystem determines "end of rock" and resets the system. A recorder is provided that records signals only during rocking. Timing information is provided on a separate channel to permit later time line analysis. The rocking motion sensor system utilizes primarily solid state CMOS circuits with a combination of synchronous-asynchronous timing. The recorder is a modified commercial unit. The two units are separate, portable, and belt mounted. Tests have been made and results will be presented.

Biomedical Engineering↗