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Biomedical subjects

J E Martins

Publications and source records attributed to J E Martins.

18 recordsLinked to original sources
PubMed2000

Pityrosporum folliculitis: renal transplantation case report.

Pityrosporum folliculitis is caused by the fungus Pityrosporum ovale. It is characterized by the presence of pruriginous follicular papulae and papulae-pustules in face, upper part of the trunk, and upper limb root. It is more prevailing in places with hot and humid climates. Its incidence can be associated with either immunosuppressive or chemotherapy states secondary to pathologies. We report herewith a case of pityrosporum folliculitis in a patient who had previously underwent kidney transplantation and these result of the itraconazol therapeutics given.

Adult↗
PubMed2000

UVB-induced acantholysis in endemic Pemphigus foliaceus (Fogo selvagem) and Pemphigus vulgaris.

BACKGROUND: The autoantibody-mediated disease in fogo selvagem (FS) is aggravated by sunlight exposure. OBJECTIVE: The aim of this study was to test whether UVB exposure of uninvolved skin of patients with FS (n = 21) enhances epidermal acantholysis and in vivo binding of FS autoantibodies as compared with a control group (n = 4). Another control group included 8 patients with pemphigus vulgaris (PV). RESULTS: Exposure of uninvolved skin of FS to UVB induces acantholysis (15/21 patients) with in vivo binding of IgG and C3 to the epidermal intercellular spaces (17/21 patients). Similar results were found in PV (6/8 patients). The test was negative in the control group. CONCLUSION: Sunlight exposure is harmful in the clinical course of patients with FS and those with PV. Protection from sunlight should be part of the treatment of these patients.

Acantholysis↗
PubMed1995

Erythroderma: analysis of 247 cases.

The profile of 247 patients with erythroderma during a 23 year period from January, 1962 through March, 1985, with a follow-up period ranging from 1 to 26 years were analysed. The patients presented with diffuse erythema, scaling and pruritus of more than 2 months' duration, and the age ranged from 16 to 60 years. Psoriasis was the most frequent underlying disease with an estimated frequency of 44.9%, the reaction to the use of drugs appeared in 7.3% of total cases and association with reticulosis showed a frequency of 4.1%. The cause of the erythroderma could not be determined in 29.2% of the cases. Six differences in terms of underlying diseases were not observed. One or more skin biopsies along with clinical findings were diagnostic or suggestive of the underlying disease in 63.6% of the cases. Repeated skin biopsies are recommended as the best method for etiologic diagnosis of erythroderma. At P = 0.05 significance level, masculine/feminine ratio of 2:1 was found. The question arises whether causal agent of erythroderma may not be somehow related to different exposure by sex to environmental antigens.

Adolescent↗
PubMed1993

Cephalometric standards for white Brazilians.

Lateral cephalometric radiographs were obtained from 30 individuals that were equally divided into groups by gender. Their ages varied from 18 to 31 years. All were white Brazilians with normal dental occlusions and good facial profiles. A combination of angles and linear measurements from Steiner's and Downs' analyses were determined. Means and standard deviations were calculated for the sample. Student's t test did not show a statistically significant difference between men and women. The entire sample was compared with the North American standards reported by Steiner and Downs. Statistically significant differences were found for GoGn/SN and SND angles. The statistically greater values of 1/NA(mm), 1/NB(mm), and 1/NA(degrees) for the Brazilians indicate typical morphological aspects with protrusive incisors. These differences and the great variation within the sample should be taken into account when formulating an orthodontic treatment plan for Brazilians.

Adolescent↗
PubMed1988

Mineral balance and blood pressure in the young spontaneously hypertensive rat.

To evaluate factors that might be related to the pathogenesis of hypertension in spontaneously hypertensive rats (SHR), mineral balance studies were conducted in SHR and control Wistar-Kyoto (WKY) rats at the ages of 9, 13 and 16 wk. During the first balance period, before onset of hypertension, Na, Ca, Mg and P balances were all significantly more positive in SHR than in WKY rats. Percentage of absorbed Na excreted in urine was correlated with the rise in blood pressure of SHR but not of WKY rats during the first 4 wk of the study. At 13 wk balances of all four nutrients still tended to be higher in SHR. During the 16th wk of life, after onset of hypertension, Na, Ca and P balances were similar in SHR and WKY rats, but Mg balance was significantly lower in SHR. The percent urinary excretion of absorbed Na was lower in SHR at 9 wk of age, but after onset of hypertension it was similar to that in WKY rats. Food intake was always greater in SHR, whereas growth during the study was less, and absorption of Ca, Mg and P declined more rapidly with age in SHR than in WKY rats. The data suggest that nutrient malabsorption in SHR, if it occurs at all, is most likely an effect of, rather than a cause of, hypertension.

Absorption↗
PubMed1983

Dermal collagen distribution. A histochemical and ultrastructural study.

Normal skin biopsy specimens obtained from 5 representative species of mammals, including man, were studied by the silver impregnation technique for reticulin fibers, by the histochemical Picrosirius-polarization method which is specific for collagen, and by transmission electron microscopy. The finely woven meshwork of argyrophilic reticulin fibers present in the adventitial dermis showed characteristics which are typical of collagen type III, when studied by aid of the Picrosirius-polarization method and by electron microscopy. On the other hand, the coarse collagen fibers of the deeper layers displayed ultrastructural and histochemical aspects which are characteristic of collagen type I. The foregoing observations support previous biochemical and immunohistologic findings, strongly suggesting that collagen type III is found mainly in the upper dermis while collagen type I predominates in the deeper layers.

Animals↗
PubMed1983

[Histopathological study of the cubital epineurium in patients with undifferentiated forms of Hansen's disease].

Twelve hanseniasis patients, undifferentiated group, with negative bacilloscopy and having undergone no prior treatment, were submitted to a biopsy of the cubial epineurium for histopathological study. All subjects were clinically observed after one month, and six of them were examined 4 to 5 years afterwards. Histopathology of the epineurium presented acid-fast bacilli in one patient and tuberculoid granuloma formation tendency in another. Epineural thickening was observed in nine patients and perivascular lymphomonocuclear inflammatory infiltration in six. The clinical examination after 1 month in the 12 patients as well as after 4 to 5 years in 6 of them, demonstrated innocuousness of the performed biopsy. Four to five years after the initial observation, the clinical examination showed that two patients who remained Mitsuda negative did not present histopathologically thickened epineurium at the beginning, while in four patients who then presented positive Mitsuda, the initial histopathological examination showed epineural thickening. Among the nine patients having a histopathologically thickened epineurium, six did not present initial lesions in the upper limbs. Therefore, the study of the cubital epineurium early thickening deserves special mention, and should be performed in a larger number of patients, as well as in control groups, since the follow-up of four among six patients showed epineural thickening and reversal of the Mitsuda reactions to positivity.

Adolescent↗
PubMedDate not supplied

[Experimental evaluation in mice of vitamin B complex repellent activity against Culex quinquefasciatus].

One untested but widely held opinion in Brazil is that oral use of vitamin B complex is useful as a mosquito repellent. We exposed Balb-C mice to a large number of Culex quinquefasciatus females, after giving vitamin B complex to mice (drops by mouth). There was no difference between mice attractiveness to mosquitoes in the vitamin B group compared to normal, but very few of the females bite mice in both groups, so the experiment was inconclusive. We suggest further experiments in this subject, using other models were the animals are more attractive to mosquitoes.

Animals↗