Search PubMed⌕ Search

Biomedical subjects

J E Martin

Publications and source records attributed to J E Martin.

At least 19 recordsLinked to original sources
PubMed1979

An analysis of the hyperactive syndrome: a comparison of hyperactive, behavior problem, asthmatic, and normal children.

In an attempt to determine whether the commonly described deficits associated with hyperactivity--inappropriate activity, short attention span, low frustration tolerance, and impulsivity--are unique to this population, hyperactive, behavior problem, asthmatic, and normal control children were studied. The test most often used in research with hyperactives were administered. Hyperactives, when compared to normals, did show deficits in the aforementioned areas. However, when compared to the behavior problem and asthmatic children only the attentional deficits clearly differentiated hyperactives from the other children.

Asthma↗
PubMed1979

The detection and diagnosis of early occult and minimal breast cancer.

This article has attempted to describe the present status of efforts toward routine detection of breast cancer at a stage when it is readily curable and to point out, not only the potentials of screening programs, but also the problems and difficulties that beset them. We believe that efficient, safe screening and accurate early diagnosis are achievable and that trial directed toward this end should not only continue but expand. We see no other avenue that offers as bright a prospect for a meaningful reduction in breast cancer mortality and the monstrous toll--medical, emotional, sociologic and monetary--it exacts.

Adult↗
PubMed1979

A social learning approach to vocational training of the severely retarded.

Seven severely retarded adults from a small rural developmental centre were treated for in appropriate vocational behaviour in the centre's workshop. Target types of behaviour were accurate and efficient performance of three types of operationally defined work behaviour collectively called work skills. Specific inappropriate behaviour for individual residents included chin wiping, inappropriate touching, and eyes off task. Training involved providing instructions, performance feedback, role-playing, and social and monetary reinforcers, which resulted in improvement in all types of targeted behaviour. Follow-up four weeks after treatment was conducted revealed a maintenance of gains on target behaviour.

Education of Persons with Intellectual Disabilitie↗
PubMed1979

Pharmacokinetic determinants of penicillin cure of gonococcal urethritis.

In a 1964 study of the pharmacokinetic determinants of penicillin cure of gonococcal urethritis, 45 male prisoner volunteers were experimentally infected with strains of Neisseria gonorrhoeae having known in vitro penicillin susceptibility. After developing urethritis, subjects received intramuscular penicillin G and had serum samples obtained serially to determine penicillin concentration. Using a multiple regression technique, we studied patient-associated parameters and parameters of the serum penicillin curves to determine the best predictors of treatment results. Cure was best predicted by the time the serum penicillin concentration remained above three to four times the penicillin minimum inhibitory concentration of the infecting strain (probability of correct classification, >0.80). Those cured had serum penicillin concentrations which remained in this range for means of 7 to 10 h. Our findings confirm principles of antimicrobial therapy derived from animal models and may have application in studying therapy of gonorrhea and other infectious diseases.

Adult↗
PubMed1979

The effects of feedback on blood pressure discrimination.

Discrimination of blood pressure in the natural environment as a function of feedback was assessed. Seventeen normotensives screened for blood pressure lability were randomly assigned to two groups. These subjects were then asked to estimate their systolic and diastolic blood pressure values two times per day over a 4-week period. Feedback for accuracy of blood pressure discriminations was implemented across the two groups in a multiple baseline fashion, using a feedback withdrawal condition in Group I to assess maintenance effects over time. Results showed improvement in discrimination accuracy for subjects in both groups when feedback was used, and no decrement in performance over a 2-week period after feedback was removed for subjects in Group I. Discrimination of systolic pressures improved at a slightly faster rate than discrimination of diastolic pressures.

Adolescent↗
PubMed1979

Assessment of smoking behavior.

The nature of smoking risk is first reviewed and a classification of procedures for assessing smoking behavior is presented. Areas requiring assessment include not only the traditionally measured smoking rate, but also the substance used and topography of consumption. Each of these areas may be assessed through a variety of self-report, observational, or indirect techniques. These techniques as well as some of their advantages and disadvantages are presented. Recently published (1975 to mid-1978) data-based smoking research appearing in four journals (Addictive Behaviors, Behavior Therapy, Journal of Applied Behavior Analysis, and Journal of Consulting and Clinical Psychology) is then reviewed with respect to measurement reliability and the use of multiple measures. Results show a strong tendency to assess only the risk area of smoking rate and a low frequency of appropriate measurement reliability checks, especially during baseline and treatment phases. Some of the implications of these results are discussed.

Humans↗
PubMed1979

Breast cancer missed by mammography.

Because a "negative" mammogram that is followed by a biopsy diagnostic of cancer is a matter of deep concern, a retrospective review was conducted of 48 such missed diagnoses at four Breast Cancer Detection Centers. The study group comprised 40,000 women participating in breast cancer screening examinations. From 3,271 biopsies during screening, 499 cancers had been found. Biopsies in the interval between screening examinations totaled 630 and yielded 48 malignancies. These 48 interval cancers were studied in an attempt to discover why they were not found on the preceding mammographic examination. Three major categories of error were disclosed and each is discussed: (1) poor radiographic technique; (2) absence of radiographic criteria of cancer; (3a) obvious oversight by the radiologist; and (3b) lack of recognition of subtle radiographic signs. This last reason is discussed in detail in the belief that better recognition of these indirect radiographic signs will lead to more accurate diagnoses, particularly in early cancers.

Adult↗
PubMed1979

Sexual experimentation by adolescents while babysitting.

This paper deals with the sexual experiences an adolescent might have as a result of babysitting. The impact of babysitters in our culture has been ignored in the literature, and yet we find it practiced widely by teenagers in the United States. Parents and society in general have few guidelines in sitter selection and in recognizing the potential impact of the sitter on their children.

Adolescent↗
PubMed1978

An evaluation model for school health services.

The following article represents a summary of a study conducted during the 1976-77 school year in Virginia. The investigation was an attempt to describe some characteristics of school health services around the Commonwealth. The study also provided an opportunity to implement an evaluation model designed specifically for the Virginia situation, but its flexibility allows for modification in order to meet the evaluation needs of other school populations.

Communicable Disease Control↗
PubMed1978

Quantitative study of the decussating optic axons in the pony, cow, sheep, and pig.

A quantitative study of optic axons in the optic tracts of several species was performed to determine the number and percentage of optic axons that decussate. Animals were prepared by unilateral ocular enucleation, and light microscopic techniques were employed to count the fibers. The mean number of fibers projecting from a single eye was 732,119 for the pony, 1,041,739 for the cow, 534,755 for the sheep, and 442,629 for the pig. The mean degree of crossover at the chiasm was 80.8% in ponies, 82.9% in cattle, 88.9% in sheep, and 87.8% in pigs.

Animals↗
PubMed1977

Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine.

The effects of pineal indole compounds on the response of the neonatal rat anterior pituitary gland to LH-releasing hormone (LHRH) were studied in organ culture. After 24 h of culture under control conditions, pituitary glands from 5-day-old female rats were routinely incubated for an additional 24 h with the test compounds. Medium LH content was determined by double antibody radioimmunoassay. LHRH (10(-9) M) induced a 10-fold increase in LH levels over control values. Melatonin at a concentration of 10(-9) M significantly reduced the LHRH-stimulated release of LH; maximal suppression to 14% was attained with 10(-8) M melatonin. Similarly, 10(-8) M LHRH caused a 26-fold elevation in medium LH which was suppressed to 62, 55, and 47% by 10(-9), 10(-8), and 10(-7) M melatonin, respectively. In short-term experiments, inhibition was evident within 30 min of treatment. A developmental study of the effect of melatonin on LH release revealed significant inhibition with pituitary glands from rats 2, 5, and 10 days of age but not with glands from animals 21 and 30 days of age. Other pineal indoles were tested for their effects on the LH response to a single dose of LHRH (3 x 10(-10) M). Serotonin at a concentration of 10(-9) M significantly suppressed LH release; maximal reduction to 37-53% occurred with 10(-8) to 10(-6) M serotonin. 5-Methoxytryptamine also produced an inhibition which was significant only at 10(-6) M, the highest concentration tested. N-Acetylserotonin, 5-hydroxyindoleacetic acid, 5-methoxyindoleacetic acid, 5-hydroxytryptophol, and 5-methoxytryptophol showed no consistent inhibitory activity at doses up to 10(-7) M. These findings indicate that melatonin, serotonin, and 5-methoxytryptamine can act directly on the neonatal pituitary gland to suppress LHRH-induced release of LH.

5-Methoxytryptamine↗
PubMed1976

Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor.

Neonatal rat anterior pituitary glands treated in organ culture with 1 nanomolar luteinzing hormone-releasing factor (LRF) showed a tenfold increase in medium luteinizing hormone (LH) concentrations over control values. Simultaneous treatment of the glands with 1 nanomolar melatonin significantly reduced the stimulatory effect of LRF on release of LH. This finding indicates that melatonin can act directly on the neonatal pituitary to inhibit the LH response to LRF.

Animals↗