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Biomedical subjects

J E Levenson

Publications and source records attributed to J E Levenson.

17 recordsLinked to original sources
PubMed1990

Successful medical management of Acanthamoeba keratitis.

Seven patients with documented Acanthamoeba keratitis were treated with prolonged and intensive triple antiamoebic therapy consisting of topical neomycin-polymyxin B-gramicidin, propamidine isethionate 0.1%, and miconazole nitrate 1%. Additionally, five patients were treated with topical corticosteroids. Six of seven patients were cured of Acanthamoeba keratitis with medical therapy alone, one patient required therapeutic penetrating keratoplasty to eradicate the infection. Two patients underwent penetrating keratoplasty to improve their vision after medical therapy. Our series differs from previous reports in that triple antiamoebic therapy was used in all seven patients and was successful in both early and advanced cases of Acanthamoeba keratitis. Prolonged and intensive topical therapy with these three antiamoebic drugs may be an effective mode of therapy for Acanthamoeba keratitis.

Administration, Topical↗
PubMed1989

Four cases of keratoconus and posterior polymorphous corneal dystrophy.

We examined four young men with keratoconus and posterior polymorphous corneal dystrophy. All four patients showed central corneal steepening and irregularity, and large areas of irregular polymorphous opacification at the level of Descemet's membrane (in at least one cornea of each patient), which are consistent with posterior polymorphous dystrophy.

Adult↗
PubMed1987

Induction of acute corneal allograft rejection by alpha-2 interferon.

A 38-year-old man who underwent corneal transplantation in 1973 for treatment of a keratoconus is described. In 1982, hairy cell leukemia was diagnosed and he was treated with splenectomy followed by chlorambucil and androgen therapy. In April 1984, treatment with alpha-2 interferon was begun, and two weeks later, evidence of acute corneal allograft rejection developed. The allograft rejection responded to temporary discontinuation of alpha-interferon and the administration of topical corticosteroid. Treatment with interferon was resumed, and he has subsequently had no clinical evidence of rejection. Although the mechanism of antineoplastic activity of alpha-interferon in hairy cell leukemia is unknown, the observations described in this report suggest that clinically important immune phenomena may occur in patients undergoing interferon therapy.

Adult↗
PubMed1984

Dematiaceous fungal keratitis following penetrating keratoplasty.

A keratitis with an unusual, sessile, filamentary mass extending into the anterior chamber developed in a patient three weeks after penetrating keratoplasty. The causative organism was identified as Exophilia (Wangiella) dermatitidis, a dematiaceous fungus. The infection was cured with a combination of medical and surgical therapy. Inoculation of the isolate into rabbit corneas produced a similar keratitis from which the same organism was cultured. Miconazole levels measured in corneal tissue removed at surgery were approximately 25 times greater than the minimum inhibitory concentration for the fungal isolate.

Adult↗
PubMed1981

UCLA clinical trial of radial keratotomy. Preliminary report.

A clinical trail of radial keratotomy ws begun under a strict research protocol at the Jules Stein Eye Institute in November 1979. The results for the first 52 eyes undergoing radial keratotomy are reported three months after surgery. Preoperatively uncorrected visual acuity was less than 20/200 in all 52 eyes. and postoperative visual acuity was less than 20/200 in 11 eyes (21%). Three months postoperatively, uncorrected visual acuity was 20/40 or better in 27 eyes (52%) and 20/20 or better in 13 eyes (25%). Postoperatively the best-corrected visual acuity decreased in 10 eyes (20%), but maximum decrease in any eye was one line of snellen letters. Preoperatively mean refractive error was -4.9 (/+-2.2) diopters, and postoperatively the mean decrease in myopia was 3.4 (/+-2.2) diopters. Postoperatively 13 eyes (25%) had a hyperopic refractive error of +0.25 to +3.25 diopters, but all of these eyes were able to accommodate and obtain 20/20 visual acuity without glasses. Postoperatively there was no statistically significant change in axial length, anterior chamber depth, or scleral rigidity, but there was a mean corneal endothelial cell loss of 10% (P = 0.0002). Decrease in myopia achieved by radial keratotomy did not correlate with the steepness of corneal curvature, corneal diameter, or scleral rigidity. Three months after surgery, significant symptoms of glare were present in 10 eyes (20%0, and annoying variable visual acuity was noted in five eyes (10%).

Adult↗
PubMed1980

Corneal endothelial damage from previously implanted intraocular lenses.

Intraocular lenses which had been surgically removed from human eyes were compared to new uncoated IOLs with regard to damage caused by dynamic and static contact with fresh rabbit corneal endothelium. Previously implanted IOLs caused consistently less endothelial damage. Possible mechanisms and the implications of these findings for the corneal surgeon doing pseudophakic keratoplasty are discussed.

Aged↗
PubMedDate not supplied

Corneal edema: cause and treatment.

Corneal edema, adequately understood and appropriately treated, has a good prognosis. The pathophysiological bases and the various causes are considered. Goals and techniques of medical and surgical therapies are reviewed.

Acetazolamide↗