Biomedical subjects
Publications and source records attributed to J E Knapp.
An ethanol extract of the roots of Cryptolepis sanguinolenta (Asclepidaceae) afforded, after partitioning and chromatography, the alkaloids quindoline and CSA-3. The structural elucidation of CSA-3 is currently in progress. Cryptolepine was also isolated from this species.
A phytochemical investigation of the roots of Tiliacora funifera (Menispermaceae) resulted in the isolation and identification of funiferine N-oxide, a new bis(benzylisoquinoline) alkaloid.
A phytochemical investigation of an ethanolic extract of the fruit of Cocculus carolinus resulted in the isolation and characterization of the alkaloids, cocculolidine and cocculine. The cyccculine, magnoflorine, and palmatine, previously reported in the stems and leaves of this species, were also isolated and identified.
An ethanol extract of the root of a Mexican variant of Cannabis sativa L.(marijuana) afforded, after partitioning and chromatography, the new spermidine alkaloid cannabisativine.
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Triclisia dictyophylla Diels (Menispermaceae) is a woody climber indigenous to West Africa which has been used natively as a medicinal in the treatment of several ailments. Chromatography of an extract of the whole plant afforded tridictophylline (3), a new morphinan alkaloid whose structure was established by a consideration of spectral data and confirmed by x-ray crystallographic analysis. The bisbenzylisoquinoline dibenzodioxin alkaloids cocsuline (1) and trigilletimine (2) were also isolated from the same extract.
This article is a comprehensive review of the published activities of the Microbiology Subcommittee of the USP Committee of Revision for the 1995-2000 revision cycle. The activities of this revision cycle were designed to position USP activities in microbiology that will be useful as technology advances. In addition to reviewing the changes accomplished, this article discusses the rationale for many of the changes and some background information on new initiatives underway. Where appropriate, changes in the USP that did not fall under the direct purview of the MCB Subcommittee but of interest to the microbiology community are also discussed.
When grown on a malt extract-glucose medium, Aspergillus parvulus Smith (ATCC "169911) produced at least four metabolites detectable on thin-layer plates with ferric chloride spray. Two of these metabolities, asparvenone (7-ethyl-3,4-dihydro-4,6,8-trihydroxy-1(2H)-naphthalenone) and O-methylasparvenone (7-ethyl-3,4-dihydro-4,8-dihydroxy-6-methoxy-1(2H)-naphthalenone), were isolated and their structures determined. The structure of O-methylasparvenone was determined by chemical and spectral means and X-ray crystallographic studies of its monoacetate. The structure of asparvenone was deduced by spectral and chemical means and by methylation with diazomethane to O-methylasparvenone.
A phytochemical investigation of the acidic fraction from an ethanolic extract of the roots of Ruscus aculeatus L. (Liliaceae) has resulted in the isolation and identification of a sterol mixture, a fatty acid mixture, chrysophanic acid, a new compound named euparone and an incompletely characterized phenolic substance.