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Biomedical subjects

J E Josephson

Publications and source records attributed to J E Josephson.

At least 37 records · Page 2Linked to original sources
PubMed1988

Ocular side effects of isotretinoin therapy.

Isotretinoin (Accutane Capsules) is a synthetic vitamin A compound used for treatment of recalcitrant cystic acne. It has numerous ocular toxic side effects which include anterior segment inflammation, dry eye syndrome, contact lens intolerance, altered refraction, photosensitivity, and reduced night vision. Eye care practitioners should be aware of these potential side effects and be prepared to communicate with the prescribing physician if side effects present.

Anterior Eye Segment↗
PubMed1988

Differentiation of corneal complications observed in contact lens wearers.

Corneal epithelial cystic formations and epithelial infiltrates are relatively common in contact lens patients. Accurate diagnosis of these conditions is needed for proper management of the patient, but the observation and differential diagnosis is hampered by the minute size and similar biomicroscopic appearance of these conditions. This paper presents a description of these subtle formations and the slit lamp techniques for differentiating epithelial microcysts, vacuoles, bullae, and infiltrates. The clinical significance of these conditions is also discussed.

Contact Lenses↗
PubMed1988

The dangers of distilled water in contact lens maintenance.

The reports of serious corneal infection associated with hydrogel lens wear prompted us to explore the level of sterility of the distilled water used by lens wearers in our practice. Fifty patients supplied samples of their partially-used distilled water for testing. Of the samples, 12% were found to be contaminated. Five samples of previously unopened distilled water were tested and no growth was found. We recommend that patients do not use distilled water for the care of hydrogel contact lenses. Rather, sterile unit dose or multi-dose (aerosol) nonpreserved, or preserved salines can be used.

Bacteria↗
PubMed1987

Spoilage of hydrogel contact lenses by lipid deposits. Tear-film potassium depression, fat, protein, and alcohol consumption.

"Jelly-bump" deposits, which are composed mainly of lipids, on high water content, extended-wear hydrogel lenses, are a clinically significant problem of unknown etiology. The authors explored the effect of nutrition on the frequency of deposition of these jelly bumps. Forty-three patients were included in this masked case-control study from five contact lens practices in North America. Thirty patients were lipid-depositor cases and 13 were controls. Tear specimens were drawn and analyzed for potassium by atomic-absorption spectrophotometry. Detailed dietary histories were conducted and diet nutrient composition was computed. Patients with diminished tear-potassium concentrations have an increased risk of jelly-bump deposition. Elevated intake of protein, alcohol, and cholesterol also appeared to be correlated significantly with increased jelly-bump deposition. The authors found that diabetics and the use of diuretics, anticholinergics, sympathomimetics, were associated with tear-film potassium depletion and lipid deposit formation.

Adolescent↗
PubMed1987

Visual field loss with colored hydrogel lenses.

The visual fields of 10 healthy myopic patients were compared using hydrogel lenses with a clear pupil and an opaque colored portion covering the iris and clear hydrogel lenses. Significant (greater than 10 degrees) field loss was found in all cases when the midperipherally colored lenses were worn. Patients interested in these lenses should be advised of this slight reduction of peripheral vision before fitting.

Contact Lenses↗
PubMed1987

Exploring the sting.

Stinging on insertion has been reported by hydrogel lens wearers after use of the AOsept system. The authors investigated the pH of AOsept and various salines used in conjunction with AOsept to determine if there were differences. A significant range (6.57-7.25) was found in the various solutions. The authors recommend the use of a sterile buffered saline as a morning soak for patients using the AOsept system.

Contact Lenses↗
PubMed1987

Monovision vs. aspheric bifocal contact lenses: a crossover study.

Twenty selected presbyopic patients were fitted with both monovision correction and Hydrocurve bifocal contact lens correction in a crossover study. Eighty percent of the population preferred bifocal correction and 20% preferred monovision. The results suggest that bifocal contact lens correction should be explored prior to considering monovision correction.

Consumer Behavior↗
PubMed1986

Sorbic acid revisited.

135 patients wearing hydrogel lenses were prescribed a care system of sorbic acid preserved surfactant, Lensept and Bausch and Lomb Sensitive Eyes Saline (sorbic acid 0.10%). Fifteen percent of patients presented with an adverse ocular response to their care system. The etiology was attributed to sorbic acid as the use of nonpreserved saline eliminated the signs and symptoms. This incidence of reaction is similar to those published earlier on thimerosal preserved saline and sorbic acid preserved saline.

Contact Lenses↗
PubMed1986

Bifocal hydrogel lenses: an overview.

Until the advent of bifocal hydrogel lenses, monovision or reading glasses were the modes of correction for hydrogel contact lens wearing presbyopes. Recent design innovations and improvements in the manufacturing technology of soft contact lenses have made possible new developments in bifocal hydrogel lenses. Patient selection and patient education play key roles in optimizing patient success. There are several hydrogel bifocal designs that are possible for the presbyope. The variations of these designs and their pertinent considerations are discussed.

Contact Lenses↗
PubMed1981

Selecting an appropriate hydrogel lens care system.

The selection of the appropriate hydrogel lens care system must incorporate an understanding of the properties and actions of cleaning, disinfecting and rinsing solutions; the characteristics of the lens; and the ocular characteristics of the patient. When changes in a care system are required, reselection involves recognizing: the nature of adverse ocular responses; the nature of deposits; any changes in patient characteristics; the characteristics of potential new products. These factors are considered and used to create an approach to selecting the initial care system and to reselecting an alternate care system.

Contact Lenses, Hydrophilic↗