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Biomedical subjects

J E Jordan

Publications and source records attributed to J E Jordan.

At least 73 records · Page 4Linked to original sources
PubMed1978

Tuberous sclerosis in old age.

A case of tuberous sclerosis without seizures in a 64-year-old man has been presented. Typical cutaneous, retinal, and bone lesions were found, along with calcifications in the lateral and third ventricle. Tuberous sclerosis is generally seen in young patients, though its occurrence in elderly patients has been described in the literature. Diagnosis in the present case was delayed. It is hoped that reemphasis of this aspect of tuberous sclerosis will lead to a prompt diagnosis in similar cases.

Age Factors↗
PubMed1978

The usefulness of routine electrocardiographic monitoring in the EEG laboratory.

In two groups of 500 unselected general hospital patients, EKG abnormalities were found in the EEG lab in 7% and 18.6%. While the most common abnormality was premature ventricular contractions, a wide variety of serious and minor abnormalities were seen, in some instances of emergent nature. Cardiac disease was unsuspected in around 40% of these patients and confirmed in a majority of these when looked for. Depending on the EKG abnormality, hyperventilation was shown to have an adverse effect 9--50% of the time in patients with normal EKG's, it tended to produce an increase of heart rate, but this was not invariant and the change in heart rate was not related to air exchange or EEG change. It is easy for any EEG laboratory to record EKG with existing equipment, and the results of this study suggest that it should be incorporated as a routine procedure. Moreover, the data indicated that hyperventilation is not necessarily a benign procedure. It should be undertaken only after control EKG recordings and assessment of the patient's cardiac status, and performed with EKG monitoring.

Aged↗
PubMed1977

Normal laboratory values in Beagle dogs of twelve to eighteen months of age.

Analyses of several body fluids are reported on Beagle dogs and compared with previous studies. All of the spinal fluid data and most of the urine data have not been previously reported in Beagles. Values of creatine phosphokinase, urine 5-hydroxyindoleacetic acid, and urine vanillymandelic acid are reported in the present study.

Animals↗
PubMed1975

Effects of cholecalciferol on the translocation of calcium by non-everted chick ileum in vitro.

An apparatus is described that allows perfusion of a non-everted segment of intestine in vitro and the study of the accumulation of substances within the mucosal cells. The translocation of Ca(2+) by rachitic-chick ileum and the effect of pretreatment with cholecalciferol was investigated, with the following conclusions. (1) Entry of Ca(2+) across the microvilli into mucosal cells is by diffusion; it does not require metabolic energy or the presence of any other inorganic ions. (2) Pretreatment of the chick with cholecalciferol causes increased permeability of the microvillus to Ca(2+) in both directions (lumen to cell, cell to lumen). The increased transport brought about by cholecalciferol in vivo can be partially mimicked by sodium dodecyl sulphate added in vitro. (3) The sign and the magnitude of the electrical potential difference prevailing across the ileum does not influence Ca(2+) transport. (4) Exit of Ca(2+) from the mucosal cell is temperature-sensitive, requires metabolic energy and Na(+). (5) Pretreatment with cholecalciferol caused increased movement of Ca(2+) out of the cell across the basement membranes. This effect of cholecalciferol given in vivo could be markedly increased by the presence of dicyclohexylcarbodi-imide in the perfusion fluid. These observations suggested that cholecalciferol increased Ca(2+) entry (and exit) at the mucosal surface and also caused Ca(2+) to be more available to the pump at the serosal surface.

Anaerobiosis↗
PubMed1975

Evaluation of the electrosleep machine.

Seven dogs were intensively studied to determine the clinical, physiological, biochemical, and pathological effects of the electrosleep machine. Both the normal dose and a high dose of current was studied. The most notable finding was an increasing number of histologic findings with increasing current dose. There is some question regarding the true nature of these findings. Other changes which were less definite included: EEG slowing and depression of the amplitude of the B-wave in the ERG. Suggestive changes included a chronic increase in pulse rate. Because of the small number of subjects, further studies are indicated to investigate further the findings of this study.

17-Ketosteroids↗