Accuracy of physicians' office laboratory results.
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Facility Regulation and Control↗
Biomedical subjects
J E Huffstutter
Publications and source records attributed to J E Huffstutter.
Cellular immunity to collagen and laminin in scleroderma.
Peripheral blood mononuclear cells (PBMC) obtained from scleroderma patients and normal controls were cultured in the presence of types I and IV collagen, intima collagen, laminin, and phytohemagglutinin. PBMC from 9 of 19 patients (47%) demonstrated lymphocyte transformation in response to laminin, and those from 2 of 17 patients (12%) demonstrated reactivity to type IV collagen. None of the patient PBMC were responsive to type I collagen or to intima collagen. Healthy controls failed to demonstrate lymphocyte transformation in response to laminin or collagens. Analysis of clinical data, including age, disease duration, and degree of skin thickening and internal organ involvement, failed to predict the response to laminin or type IV collagen. The significance and disease specificity of this cellular immunity to laminin and, with lower frequency, to type IV collagen, that occurs in some scleroderma patients are unknown.
Adult↗
A modified scleroderma skin scoring method.
The extent of skin thickness in scleroderma has been reported to correlate with the degree of internal organ involvement. An objective method for the clinical evaluation of skin involvement (skin score) in scleroderma is described. In this preliminary study, the method was tested in twenty scleroderma patients. An acceptable degree of inter-observer reproducibility was noted. This method is proposed as a means of monitoring the degree of skin involvement and the overall disease activity.
Humans↗