Association of enteroaggregative Escherichia coli with travellers' diarrhoea.
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Diarrhea↗
Biomedical subjects
J E Hassall
Publications and source records attributed to J E Hassall.
Ischaemic necrosis of the ilium complicating haemolytic anaemia due to an unstable haemoglobin.
A case of ischaemic necrosis of bone (INB) affecting the right hemipelvis in a 57 year old woman with an unstable haemoglobinopathy is presented. The rarity of INB in this site, the usefulness of nuclear scanning, and the relation between haemolytic anaemia and INB are discussed.
Anemia, Hemolytic↗
Severe autonomic neuropathy in amyloidosis secondary to rheumatoid arthritis.
Autonomic neuropathy, although reported to occur in 15% of patients with AL primary) amyloidosis, is extremely rare in AA (secondary) amyloidosis. We report a patient with amyloidosis secondary to rheumatoid arthritis in whom autonomic neuropathy resulted in severe and disabling orthostatic hypotension. Extensive amyloid deposits were found throughout the autonomic nervous system.
Amyloid↗
Faecal carriage of Clostridium perfringens.
The numbers and serotypes of Clostridium perfringens present in the faeces of three groups of hospital patients and young healthy laboratory workers were examined in studies lasting between 10 and 13 weeks. In one hospital some long-stay geriatric patients carried relatively high numbers of C. perfringens (greater than 10(7)/g) most of the time and it was not unusual in any one week for the majority of these patients to carry the same serotype(s). However, the numbers of C. perfringens in the faeces of young long-stay patients in the same hospital were in the range of 10(3)-10(4)/g and carriage of common serotypes was not observed. These results were similar to the findings with the young laboratory workers. This investigation indicates that two of the laboratory criteria often used in the investigation of C. perfringens food poisoning, i.e. faecal counts of greater than or equal to 10(5) C. perfringens/g and patients carrying the same serological type need to be interpreted with caution with suspected outbreaks involving some groups of geriatric long-stay hospital patients.
Clostridium perfringens↗
Osteonecrosis after high dosage, short term corticosteroid therapy.
A retrospective review was made of 66 patients who had undergone neurosurgical treatment for intracranial aneurysms and who had been treated with high doses of corticosteroids to reduce postoperative cerebral edema. At a mean followup time of 50.3 months, one patient had developed bilateral osteonecrosis of the hips, among 44 who were available for followup.
Adolescent↗
Current trends in the management of myasthenia gravis: plasmapheresis and immunosuppressive therapy.
In recent years a considerable body of evidence has accumulated to demonstrate autoimmune mechanisms in myasthenia gravis. This evidence has important implications for the aetiology, diagnosis and management of the disease. The primary abnormality in myasthenia gravis is related to the presence of antibody which reacts with the acetylcholine receptor. Measurement of this IgG antibody in the serum has become the most reliable diagnostic adjunct to the edrophonium test, and in an individual patient, the level of the serum antibody relates closely to the clinical indices. In cases of myasthenia where control with anticholinesterase drugs is unsatisfactory, methods to lower the antiacetylcholine receptor antibody are indicated: these may include thymectomy, immunosuppressive therapy of plasmapheresis. Two patients with very severe disease are described in whom all types of therapy were used and in whom survival depended ultimately on the use of plasmapheresis. These patients illustrate the importance of receptor antibody in the clinical manifestations of myasthenia gravis and in its management.
Acetylcholine↗
Surgical treatment of aortic valvular disease in rheumatoid arthritis.
Two patients with severe rheumatoid arthritis and aortic regurgitation, developed progressive symptoms of left ventricular failure. Symptoms were inadequately controlled by medical therapy. Surgical treatment was at first considered with great reluctance because of the theoretical risk of operative and postoperative complications in patients with a diffuse disease of connective tissue. The suspected complications did not materialize. Valvular replacement should be considered in patients with severe valvular disease associated with rheumatoid arthritis.
Adult↗