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Biomedical subjects

J E Gillespie

Publications and source records attributed to J E Gillespie.

33 records · Page 2Linked to original sources
PubMed1987

Three-dimensional computed tomographic reformations of sellar and para-sellar lesions.

The purpose of this study was to determine whether diagnostically useful three-dimensional (3D) reformations could be obtained from unmodified high resolution pituitary CT scans. Twelve CT examinations in 9 patients in whom an enhancing tumour or extensive bone destruction was identified around the sella, were studied using 3D images obtained on soft tissue and bone thresholds. 3D images were considered superior to conventional CT sections and reformations for the assessment of the vascular relations of tumours with large supra-sellar components, and in cases of extensive bone erosion. In selected cases, 3D CT imaging may facilitate a faster and more comprehensive appraisal of high resolution CT studies by clarifying otherwise complex spatial relationships.

Adult↗
PubMed1987

Three-dimensional CT reformations in the assessment of congenital and traumatic cranio-facial deformities.

Standard radiography and computed tomography (CT) produce two-dimensional representations of anatomical structures under investigation. Recent developments in computer software now enable the production, from a series of conventional CT sections, of three-dimensional images of complex anatomical structures thus providing an opportunity for improved diagnosis and treatment planning.

Facial Bones↗
PubMed1987

Three-dimensional reformations of computed tomography in the assessment of facial trauma.

Three-dimensional (3D) computed tomography (CT) reformations were obtained in 15 patients presenting with facial injuries of differing severity. The 3D images were compared with standard radiographs and high resolution CT, including multiplanar reformations, and assessed under the headings of fracture detection, extent and displacement using a simple scoring system. 3D was valuable in severe trauma with multiple fractures, providing a clear demonstration of fraction extent and fragment displacement. 3D was much less useful in minor trauma in which little or no fragment displacement had occurred, and demonstrated fewer fractures overall than either radiography or CT in all categories of facial injury. When used as part of a high resolution CT examination 3D imaging can provide useful information to both radiologist and surgeon in cases of severe facial trauma.

Facial Injuries↗
PubMed1987

Trigeminal nerve tumor: comparison of CT and MRI. Case report.

Benign tumors of the middle fossa components of the trigeminal nerve are rare. The authors describe the case history, radiological investigation, and operative findings of a patient with a large trigeminal neurofibroma of the middle fossa. The unusual mode of presentation is discussed. Valuable information was provided by magnetic resonance imaging prior to successful removal of this tumor.

Adult↗
PubMed1986

Magnetic resonance imaging in syringomyelia.

The aim of the study was to assess the reliability of magnetic resonance imaging (MRI) in the detection of syrinx cavities and to determine the proportion of cavities associated with Chiari malformation. MRI was performed in over 120 patients with neurologic deficits referable to the cranio-cervical junction. Forty-one patients were also evaluated by CT myelography (CTM). CTM demonstrated appearances consistent with intramedullary cavitation in 14 patients. MRI detected 11 of these but in 3 the appearances, including cord size, were normal. In the entire study 27 syrinx cavities were demonstrated by MRI, 8 associated with trauma, posterior fossa or spinal tumours, or spinal dysraphism. Of the remaining 19, tonsillar ectopia was present in 10 (53%). It is concluded that a lack of concordance between MRI and CTM exists in the detection of small cavities in the normal sized cord, and that syringomyelia without evidence of tonsillar ectopia is identifiable by MRI more frequently than might be anticipated.

Adolescent↗
PubMed1985

Gallbladder visualisation following paediatric cardioangiography with Hexabrix.

Fifty children had an upper abdominal radiograph performed 24 hours after cardioangiography with Hexabrix (meglumine/sodium ioxaglate). The gallbladder was clearly visualised in 32 patients (64%) in the absence of clinical or radiographic evidence of renal impairment. Total contrast dose would appear to be the main determining factor. Hexabrix differs significantly in this respect from conventional uro-angiographic contrast media (diatrizoate and iothalamate) in which opacification of the gallbladder is unusual and strongly associated with renal impairment. Possible reasons for this difference are discussed.

Adolescent↗
PubMed1980

Effect of indomethacin on desoxycorticosterone acetate-sodium chloride-induced renal lesions in the pregnant rat and her offspring.

To explore the effects of inhibition of prostaglandin synthesis on renal lesions, 37 female rats were made hypertensive and of these, 22 were treated with indomethacin. The blood pressure (207 +/- 5 mm Hg) in the indomethacin group was significantly (p < 0.01) higher than the blood pressure (191 +/- 7 mm Hg) in the control group. Weight changes were not significantly different. Renal lesions of varying severity were noted in mothers and offspring of both groups. The lesions ranged from thickening of the basement membranes to glomerular congestion, some with nearly complete eradication of glomerular architecture. Although the lesions appeared to be more marked in the indomethacin-treated group, no specific pattern of lesion location nor significant differences in the severity of the lesions was demonstrated. These data suggest that the lesions noted were the result of the hypertension. However, exacerbation by indomethacin could not be excluded.

Animals↗
PubMedDate not supplied

Timolol plus maximum tolerated antiglaucoma therapy: a one-year followup study.

Thirty-three eyes of 22 patients with primary open-angle glaucoma or severe ocular hypertension had topical timolol maleate added to their maximally tolerated medical regimens. With minimal side effects, 25 eyes (76%) could be treated medically for one year, and only eight eyes (24%) required filtering surgery. Thirteen (39%) of the medically treated eyes achieved intraocular pressures of 21 mm Hg or less. After the addition of timolol, 17 of the 33 eyes (52%) completed the one-year protocol with final mean intraocular pressure decreases of 5 mm Hg or more on medical therapy.

Aged↗