Search PubMed⌕ Search

Biomedical subjects

J E Fantasia

Publications and source records attributed to J E Fantasia.

At least 19 recordsLinked to original sources
PubMed1999

Heterotopic oral gastrointestinal cyst: report of 2 cases and review of the literature.

Oral heterotopic gastrointestinal cyst is a rare entity occurring in infants and children and showing a predilection for males. The cyst usually appears as an asymptomatic swelling in the floor of the mouth. Difficulty in feeding, swallowing, respiration, and speech have been reported in approximately 30% of those affected. The tongue-in particular, its anterior aspectis involved in up to 60% of reported cases. The clinical, radiographic, and histopathologic features of cases of heterotopic gastrointestinal cyst involving the anterior tongue in a 2-year-old girl and the anterior floor of the mouth in a 2-month-old boy are presented, and theories of pathogenesis are discussed.

Child, Preschool↗
PubMed1997

Polymorphous low-grade adenocarcinoma: flow cytometric, p53, and PCNA analysis.

Polymorphous low-grade adenocarcinoma of minor salivary glands (terminal duct carcinoma, lobular carcinoma) was first defined more than a decade ago. A 17% recurrence rate and a 9% metastasis rate have been reported. Fifteen formalin-fixed, paraffin-embedded archival cases were analyzed. Ploidy and proliferative activity were evaluated with flow cytometric analysis. Demonstration of an abnormal p53 gene product and proliferative cell nuclear antigen analyses were also performed with routine immunohistochemical procedures. The purpose of this investigation was to evaluate these parameters and determine if a correlation existed. Flow cytometry was performed on 10 cases; 3 showed an aneuploid cell line (mean, S-phase diploid tumor cells 5.9%; S-phase aneuploid 26.7%). Products of a mutation of the p53 tumor suppressor gene have been noted to accumulate in salivary gland tumors, both benign and malignant. Qualitative assessment revealed p53 positive staining in 4 of 15 tumors; positive cells comprised 5% to 10% of the tumor. The percentage of tumor cells positive for proliferative cell nuclear antigen staining ranged from 0.5% to 70%. There was no correlation between proliferative activity as determined by proliferative cell nuclear antigen when compared with results of flow cytometric analysis except for one case that exhibited p53 staining, a 26% proliferative cell nuclear antigen fraction, and a distinct aneuploid cell line.

Adenocarcinoma↗
PubMed1997

Diagnosis and treatment of common oral lesions found in the elderly.

A wide variety of oral lesions are recognized in the geriatric patient. The most common lesions include neoplasia, immunologic based mucosal disease, hematological disorders, oral manifestation of systemic disease, and conditions characterized by oral or facial pain. Diagnostic and treatment considerations for leukoplakia, carcinoma, metastatic disease, candidiasis, herpes zoster, plasmacytoma, myeloma, lymphoma, several of the more common vesiculoulcerative mucosal diseases and idiopathic burning mouth syndrome are presented.

Aged↗
PubMed1988

Labial salivary gland tumors.

A study was conducted on labial salivary gland tumors from four oral pathology laboratories. Of the 103 identified tumors, 87 (84.5%) were from the upper lip, whereas 16 (15.5%) were from the lower lip. Of the 87 upper lip tumors, 80 (92.0%) were benign. Forty-three of these were monomorphic adenomas and 37 were pleomorphic adenomas. Seven malignant tumors of the upper lip were as follows: four adenoid cystic carcinomas, two acinic cell carcinomas, and one adenocarcinoma. Of the 16 lower lip tumors, 15 (93.8%) were malignant. Thirteen of these were mucoepidermoid carcinomas and two were acinic cell carcinomas. The only benign lower lip tumor was an intraductal papilloma. These results confirm the findings of previous investigations, showing that minor salivary gland tumors are much more common in the upper lip than the lower lip, but that lower lip tumors are more likely to be malignant.

Adolescent↗
PubMed1988

Survey of tissue-diagnostic services in United States dental schools--1985.

Tissue-diagnostic services in United States dental schools were surveyed to determine activities during 1985. Results were compared with those of similar surveys conducted in 1953, 1958, 1969, 1975, and 1980. A continuing increase in the number of specimens processed has occurred, and there has been a parallel increase in the number of malignant specimens noted. The percentage of malignant specimens in relation to total specimens processed has not changed significantly.

Biopsy↗
PubMed1987

Pathologic fracture of the mandible associated with simultaneous occurrence of an odontogenic keratocyst and traumatic bone cyst.

A case is presented which involved a pathologic fracture of the mandible associated with a large radiolucent lesion extending from the parasymphysis to the coronoid notch. The osseous defect was found to involve two separate lesions, identified histologically as a traumatic bone cyst in the anterior portion and an odontogenic keratocyst in the posterior aspect. The clinical course and treatment are discussed.

Adult↗
PubMed1986

Ultrastructure of sialadenoma papilliferum.

Sialadenoma papilliferum is a rare tumor of salivary gland origin and has been reported in the parotid and minor salivary glands of the oral cavity. This tumor is morphologically similar to the papillary syringoadenoma of the sweat gland. We report the clinical and morphologic features of five cases and review the literature. Ultrastructural examination of case 1 revealed the predominant cell type to be an oncocytic cell. These cells contained numerous mitochondria, exhibited parallel filaments within the cell cytoplasm, and were attached by desmosomes. The neoplastic cells appear to exhibit characteristic features of various cell types of the salivary gland duct apparatus.

Adult↗
PubMed1984

Localization of free secretory component in pleomorphic adenomas of minor salivary gland origin.

Secretory component (a glycoprotein) is an antigenically distinct portion of the secretory immunoglobulin A, which has been identified in a number of normal and neoplastic epithelial cells. Localization of secretory component was determined in pleomorphic adenomas of minor salivary gland origin using the four-step peroxidase-antiperoxidase technique. Antiserum that detected only free secretory component (FSC) was used. Staining for secretory component was noted in the epithelium that lined duct-like spaces; but was absent in myoepithelial cells and mucous acini. These findings suggest a role for FSC in evaluating the histogenesis of various salivary gland neoplasms.

Adenoma↗
PubMed1984

Myxoid lipoma of oral soft tissue. A clinical and ultrastructural study.

Myxoid lipoma is an unusual histologic type of lipoma. This article reports four cases of myxoid lipoma that arose in the mouth. In frozen sections stained with oil red O, the cytoplasm of tumor cells stained strongly positive. Intercellular mucoid material was PAS-positive and diastase-resistant. It also stained positively with alcian blue. Electron microscopic observations revealed that adipocytes were in different stages of differentiation, with lipid globules of variable size observed in the cytoplasm. Many pinocytotic vesicles appeared at the plasma membrane. Mature adipocytes were surrounded by a basal lamina. Fibroblasts, collagen fibers, and mucoid material were scattered among adipocytes. It appears possible that, in the histogenesis of myxoid lipoma, multipotent mesenchymal cells undergo multidirectional differentiation. Some cells differentiate to produce mucosubstance, while others differentiate to become adipocytes.

Adipose Tissue↗
PubMed1982

Calcium oxalate deposition in the periodontium secondary to chronic renal failure.

Deposition of calcium oxalate in the periodontium with accompanying bone loss and tooth resorption, occurred in a 55-year-old woman on long-term renal dialysis for end-stage renal disease. These deposits were birefringent upon examination with polarized light. Scanning electron microscopy of the deposits revealed clusters of sharply angular oblong and needlelike crystals. Microincineration followed by staining with alizarin red S was positive for calcium oxalate. X-ray diffraction studies of the crystals in the tissue specimen revealed a pattern identical to that of commercially prepared calcium oxalate monohydrate. It is postulated that pre-existing inflammatory periodontal disease may have provided the appropriate milieu for the deposition and precipitation of crystals. These deposits, acting as a foreign body, further intensified the inflammatory response, resulting in extensive alveolar bone loss and external tooth resorption.

Adult↗
PubMed1981

Hyaline bodies in the connective tissue wall of odontogenic cysts.

Hyaline bodies are sometimes encountered in the connective tissue wall of odontogenic cysts. In this study, various histomorphologic types of hyaline bodies were observed in a dentigerous cyst and a residual apical periodontal cyst. Some hyaline bodies appeared to be a coagulum of serum fluid surrounded by a small number of fibroblasts. Others appeared to be composed of fibrillar structures. Still others appeared to be a mixture of various amounts of serum coagulum and fibrillar structures. Immunoperoxidase procedures revealed various amounts of serum proteins in hyaline bodies. Gomori's trichrome stain and Mallory's staining technique showed that fibrillar structures were collagenous in nature. Electron microscopy showed that fibrillar structures were frayed collagen fibrils. These observations suggest that various histologic types of hyaline bodies represent different stages of development and that the basic pathogenic mechanism is pooling of extravasated serum followed by fibrosis.

Adult↗
PubMed1980

Basal cell adenomas of the minor salivary glands. A clinicopathologic study of seventeen new cases and a review of the literature.

The basal cell adenoma (BCA) is a benign monomorphic salivary gland tumor. Those of minor gland origin tend to occur within or adjacent to the upper lip (80 percent). The BCA is an encapsulated, slow-growing lesion which most commonly affects older persons. Several different histologic patterns can be noted, and often a combination of these variations is present within the same tumor. Simple surgical excision appears to be adequate treatment.

Adenoma↗