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J E Duque-Parra

Publications and source records attributed to J E Duque-Parra.

5 recordsLinked to original sources
PubMedDate not supplied

[Neuro anatomical and neurological elements associated with the brain over the course of time].

INTRODUCTION: This article gives a sequential vision of neuro anatomical concepts which have been considered to be relevant in the past, associating them with contemporary neurofunctional and neurological viewpoints. DEVELOPMENT: We start with the most ancient written records, concerning the brain at the time of the pharaohs, followed by the classical view of the Greek physicians and subsequent writers, through the phrenological period during which the relation between bony hypertrophy and cerebral function was emphasized as being suitable for the study of cerebral function at that time. Subsequent advances directed study of the nervous system towards recognition of the cells of the cerebral parenchyma, firstly through use of the optical microscope and later the electronic microscope, to make direct observations of the synapses with the vesicles of neurotransmitters. Thus reaching the present day and considering certain aspects of contemporary investigation in neuroscience, which bring structural and physiological aspects closer together. As a multi disciplinary science diverse elements have been combined so as to investigate and understand, using various tools and methods, the basic concepts described in relation to the structure and function of the nervous system, especially the brain.

Anatomy↗
PubMedDate not supplied

[Neurobiological relations and aging].

Of the different aspects of a series of neurobiological changes that take place throughout the life cycle of an individual, in this paper we examine those involved in the aging process. These changes have been associated on different scales, including on a macroscopic level, that take into account variations in the shape, weight and volume of the brain and other encephalic structures. A part of the information about the weight seems to be incompatible and hence its incompatibility has been questioned and argued from a quantitative perspective. The functional option has been proposed as an alternative in the maintenance of normal brain functioning, as have changes on the microscopic scale in neuronal processes, the reduction in number of neurons in certain parts of the brain, which has also been questioned for the case of olfactory nerve fibres, and finally changes that take place on the molecular scale in the alteration of some neurotransmitters in certain parts, modifications suffered by mitochondrial enzymes and others that depend on the genome. These aspects have all been taken into consideration along with a resulting physiological relation in an attempt to gain a slightly more holistic, although still fragmented, view of the process, and to consider neoteny as an evolutionary strategy in the human species that serves to maintain brain functioning.

Aging↗