The excretion of tritiated digoxin in normal human volunteers before and after unilateral nephrectomy.
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Adult↗
Biomedical subjects
J E Doherty
Publications and source records attributed to J E Doherty.
Determinants of digitalis dosage.
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Age Factors↗
The clinical pharmacology of digitalis glycosides: a review.
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Blood Urea Nitrogen↗
Tritiated digoxin excretion of patients following renal transplantation.
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Adult↗
Studies with tritiated digoxin in anephric human subjects.
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Acute Kidney Injury↗
The distribution and concentration of tritiated digoxin in human tissues.
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Adult↗
Peritoneal dialysis and hemodialysis of tritiated digoxin.
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Cell Membrane Permeability↗
Recognition and management of the intermediate coronary syndrome.
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Adult↗
Tissue concentration and turnover of tritiated digoxin in dogs.
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Animals↗
Radiocarbon cholesterol turnover in cholesterol pericarditis.
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Aged↗
Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease.
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Adult↗
The management of angina pectoris.
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Angina Pectoris↗
Digoxin versus digitoxin.
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Biological Availability↗
Clinical pharmacokinetics of digitalis glycosides.
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Aged↗
Digitalis-sensitive Na+, K+-ATPase: lack of a direct catecholamine-mediated stimulation in bovine myocardial tissue.
It has been documented that biogenic amines can stimulate Na+, K+-ATPase from various tissue preparations. However, it is unclear whether or not this stimulation occurs in myocardial tissues. We have evaluated possible catecholamine stimulation of purified Na+, K+- ATPase preparations utilizing a bovine ventricular microsomal preparation. We have studied the dose response of the enzyme to ouabain and digitoxigenin in the presence and absence of propranolol and norepinephrine. Our results indicate that propranolol increases the sensitivity of Na+, K+-ATPase to inhibition by digitalis, and that stimulation of Na+, K+-ATPase in bovine myocardium is not mediated via an adrenergic mechanism. In addition, our results indicate that in myocardial tissue, both stereoisomers of propranolol produce a direct nonspecific membrane effect which can modify Na+, K+-ATPase activity.
Animals↗