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Biomedical subjects

J E Davis

Publications and source records attributed to J E Davis.

At least 91 records · Page 5Linked to original sources
PubMed1988

Polymorphic Bgl II restriction sites of DR alpha demarcate a novel HLA-DR1 antigen.

Mechanisms to account for the unusual properties of a DR1 alpha beta complex (designated DRgp50) that is resistant to dissociation under normal conditions utilized were investigated. Expression of this DRgp50 complex is highly correlated with the failure of cells from certain DR1 individuals (DR1x) to stimulate specific DR1-restricted or alloreactive T-cell clones. Pulse/chase experiments demonstrated that this DRgp50 complex was not detectable until approximately 1 h of chase. The DR1 alpha and beta chains associated into the heterodimer in the absence of glycosylation and alterations in the number of oligosaccharides or sialylation of cell surface forms were not evident when compared with normal DR1 alpha and beta chains. Restriction fragment length polymorphism patterns of DR beta genes from normal (DR1n) and DR1x individuals were indistinguishable. However, a difference in the alpha chain genes between DR1n and DR1x individuals was revealed using Bgl II. This Bgl II restriction site mapped to the 3' untranslated region of DR alpha and represents a new genomic marker to distinguish this functional and biochemical variant of DR1.

Bacterial Proteins↗
PubMed1988

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American Medical Association↗
PubMed1987

Breast carcinoma metastatic to bladder.

Breast carcinoma metastatic to the bladder and presenting initially with urinary tract symptoms has been reported only sporadically. Two cases, one unique in that the bladder was the sole site of metastasis, are reported herein, along with a review of the literature.

Aged↗
PubMed1987

The major ambulatory surgical center and how it is developed.

Of the more than 20 million surgical operations performed each year in this country, 40 to 50 per cent can be done without hospitalizing the patient, and more and more of these out-of-hospital operations are being done on patients requiring general anesthesia or a period of postoperative observation. This article reviews the advantages and disadvantages of major ambulatory surgery in general, as well as those of the different types of ambulatory surgical units. The steps in the development of a unit, including the various committees involved in its development and operation, are outlined.

Ambulatory Surgical Procedures↗
PubMed1987

Selecting the patient for major ambulatory surgery. Surgical and anesthesiology evaluations.

In assessing the patient as a candidate for major ambulatory surgery, the surgeon must make an individual and specific judgment concerning the suitability of each patient. Factors to be considered include the patient's age, general physical and mental condition, anesthetic risk, attitudes about ambulatory surgery, and social and family situation, as well as whether the current standards and customs for ambulatory surgery in that community encompass the proposed procedure. Candidates for anesthesia can be ranked with the classification of the American Society of Anesthesiologists.

Aging↗
PubMed1987

Major ambulatory surgery of the general surgical patient. Management of breast disease and hernias of the abdominal wall.

Procedures for management of breast disease and abdominal wall hernias are those that are done most commonly by the general surgeon and for which the ambulatory surgical unit is apt to be the preferred site. Surgical technique for the management of the various forms of breast disease is reviewed. Most hernias of the abdominal wall can be repaired safely, conveniently, and comfortably in the ambulatory surgical unit. Except for large hernias, no type of hernia should be categorically denied consideration for ambulatory care.

Abdominal Muscles↗
PubMed1987

Major ambulatory surgery of the general surgical patient. Management of anorectal conditions, peripheral vascular problems, and gastrointestinal endoscopy.

The growing experience with controlling postoperative pain and with using Foley catheters postoperatively has made surgeons less hesitant to perform some anorectal procedures in an ambulatory setting. Procedures for the treatment of varicose veins of lesser severity can often be done in an ambulatory surgical center. Because of the risk for respiratory complications and perforations, some endoscopic procedures are appropriate for the major ambulatory surgical unit.

Ambulatory Surgical Procedures↗
PubMed1987

The future of major ambulatory surgery.

Major ambulatory surgery has grown steadily in its availability and use for the past two decades. This growth and expansion have come about because of three facts: major ambulatory surgery has become a totally accepted modality for delivery of surgical care; it benefits all participants; and it is cost-effective. Public interest and demand, surgeon satisfaction and participation, and payor encouragement and mandate will ensure its continued growth.

Ambulatory Surgical Procedures↗
PubMed1987

Individuality and mutuality in the language of families of field-dependent and field-independent children.

The use of singular and plural first-person pronouns provided a measure of individuality and mutuality in families of 18 field-dependent and 20 field-independent children (19 boys and 19 girls). The families were observed in home and laboratory settings. Consistent with notions of a more differentiated sense of self, field-independent boys and girls used more I words; the greater social orientation of the field-dependent children was reflected in their more frequent use of we terms. Family members in the field-independent group were more varied in their use of these linguistic measures, especially in the lab. Fathers of field-independent children used more we words. These usages were discussed in terms of social control mechanisms. personal pronoun usage as indicators of separateness/connectedness in families was also discussed.

Child↗
PubMed1987

Rapid field measurement of the assimilation rate versus internal CO(2) concentration relationship in green ash (Fraxinus pennsylvanica Marsh.): the influence of light intensity.

Assimilation rate (A) versus intercellular CO(2) concentration (C(i)) relationships for leaflets of five-year-old green ash (Fraxinus pennsylvanica Marsh.) trees were computed from gas exchange measurements obtained in the field with a closed-circuit, portable photosynthesis measurement system comprising an LI-6200 gas analyzer and an LI-6000 computer, (Li-Cor, Inc., Lincoln, Nebraska, USA). Observations were made over a range of light intensities achieved by attenuating direct sunlight with neutral density filters, and over a range of ambient CO(2) concentrations achieved by breathing into the assimilation chamber and then lowering the CO(2) concentration to the desired level with the LI-6200's soda-lime scrubber. Boundary layer conductance was determined by use of a leaf replica made of moist filter paper. Typically, A-C(i) curves at four light intensities were obtained in three to four hours. The initial slope (when A = 0) of the A-C(i) curve obtained at a light intensity of 1750 micromol m(-2) s(-1) (full sunlight) was similar to that obtained at a light intensity of 840 micromol m(-2) s(-1). However, when light intensity was reduced further (to 370 and 160 micromol m(-2) s(-1)), the initial slope of the A-C(i) curve also decreased, indicating that at these light intensities, assimilation was limited by photochemical energy supply, as well as CO(2) concentration.

Journal Article↗
PubMed1987

Defective antigen presentation and novel structural properties of DR1 from an HLA haplotype associated with 21-hydroxylase deficiency.

We have segregated DR1+ individuals into two categories according to whether or not their class II+ cells stimulated T lymphocyte clones specific for or restricted to DR1. In a majority of cases (87%), failure to stimulate was a property of cells having the B14;DR1 haplotype and/or nonclassical 21-hydroxylase deficiency. Absence of clonal proliferation could not be explained by release of an intercellular suppressor factor or by stimulator cell absorption of interleukin 2. Homozygous cells inheriting both stimulatory (DR1n) and nonstimulatory (DR1x) haplotypes did not successfully mediate clonal expansion, implying that a trans acting factor operates intracellularly to modify both DR1 alleles or their products. Other DR alleles did not appear to be affected as evidence by normal proliferative responses of T lymphocyte clones restricted to DR2 or DR7 and stimulated by DR1x,2 and DR1x,7 cells, respectively. By two-dimensional gel analysis, we have further identified a 50-kD surface glycoprotein contained in anti-DR immunoprecipitates of DR1x, but not DR1n or non-DR1 cellular lysates. This 50-kD structure had antigenic and peptide identity to DR alpha and beta chains but was resistant to dissociation under conditions that normally separate DR alpha and beta (8 M urea plus 5% 2-mercaptoethanol); boiling in sodium dodecyl sulfate was required to segregate the component polypeptides of the 50-kD heterodimer. We postulate that a product of a novel combinatorial association between constitutive chains of DR may interfere with or compete for normal T cell receptor recognition of DR1 as both an alloantigen and a restricting element. We further propose that gene abnormalities within the class III region of a haplotype associated with nonclassical 21-hydroxylase deficiency may extend into the DR subregion of the major histocompatibility complex with consequent aberrations in DR1 presentation.

Adrenal Hyperplasia, Congenital↗
PubMed1986

Heat stress associated with the use of vapor-barrier garments.

Use of personal protective devices in the workplace, while intended to diminish risk of injury, may in some cases increase personal risk from environmental hazards. A case of a juvenile diabetic with complaints of near syncope while working in a plastics laminating process is analyzed. Although his symptoms might be attributed to a variety of causes, they were traced to the effects of heat stress related to wearing vapor-barrier disposable coveralls in a warm environment (85 degrees F). A field study of asbestos workers involved in abatement of asbestos steam pipe insulation illustrates how clothing impermeable to sweat may result in elevation of core body temperature. When workers use vapor-barrier coveralls, work practices or wet bulb globe temperature limits may need to be revised to prevent heat-related injury.

Adult↗
PubMed1986

Transient hypertension after percutaneous transluminal renal artery angioplasty.

A retrospective analysis of 128 technically successful percutaneous transluminal renal angioplasty (PTRA) procedures was performed. After the procedures, transient systemic hypertension (TSH) developed in 39 patients. The phenomenon usually occurred within 30 minutes of balloon dilation and always within 2 hours of PTRA. TSH lasted less than 5 hours in 35 patients and never persisted for more than 24 hours. TSH is a self-limiting process and should not be confused with the more sustained hypertension that arises from a complication of balloon angioplasty.

Adolescent↗
PubMed1986

Fluid conservation in athletes: responses to water intake, supine posture, and immersion.

The roles of antidiuretic hormone (ADH) and aldosterone in the elicited diuretic responses of trained and untrained men to seated, supine, and head-out water immersed conditions were studied. Volunteers were comprised of groups of six untrained individuals, six trained swimmers, and six trained runners. Each subject underwent three protocols, six hours in a seated position, supine position, or immersion (35 degrees C water). The last two protocols were preceded and followed by 1 h of seated position. After 10 h of fasting, 0.5% body wt of water was drunk. One hour later the trained groups had higher urine osmolalities (P less than 0.05) and urinary excretion rates of ADH (P less than 0.05) and lower urine flow rates (P less than 0.05) than untrained subjects. Throughout the sitting protocol, urinary ADH was also higher in both trained groups (P less than 0.05). Both supine posture and immersion resulted in significant decreases in urinary ADH in the untrained subjects (P less than 0.05) but no changes wer noted in swimmers and only during the second hour of immersion in the runners (P less than 0.05). The natriuresis and kaliuresis were greater during immersion than in the supine position but plasma renin activity, measured only in trained groups, and plasma aldosterone, measured in the untrained group, were decreased similarly with both protocols. The increases in urinary sodium excretion and urine flow rate were lower in trained than untrained subjects during the supine and immersion protocols (P less than 0.05). The data are compatible with an increased osmotic but decreased volume sensitivity of ADH control in trained men.

Adult↗