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Biomedical subjects

J E Connell

Publications and source records attributed to J E Connell.

13 recordsLinked to original sources
PubMed2001

Fixed-time schedule effects as a function of baseline reinforcement rate.

Using an arbitrary response, we evaluated fixed-time (FT) schedules that were either similar or dissimilar to a baseline (response-dependent) reinforcement schedule and extinction. Results suggested that both FT schedules and extinction resulted in decreased responding. However, FT schedules were more effective in reducing response rates if the FT reinforcer rate was dissimilar to baseline reinforcer rates. Possible reasons for this difference were evaluated with data analysis methods designed to identify adventitious response-reinforcer relations.

Adolescent↗
PubMed1996

Novel genetic screen for genes involved in posterior body patterning in Drosophila.

Much of our current understanding of how cytoplasmic determinants are localized and activated stems from genetic analyses in Drosophila. Characterization of mutants defective in establishing the initial embryonic body pattern has revealed the importance of mRNA localization and translational control and identified several factors required for these processes. Nevertheless, many additional genes are likely to be involved. Here, we describe a novel genetic screen designed to identify genes that participate in posterior body patterning, an elaborate process involving the sequential use of two localized cytoplasmic determinants, the products of the oskar and nanos genes. From the screen, we recovered new alleles of genes known to be required for posterior body patterning, demonstrating the validity of the approach. In addition, we isolated numerous other mutants. Further characterization of one mutant, P58, revealed that it is a novel allele of bullwinkle. We find that in bullwinkle mutants, oskar mRNA localization is not maintained in the embryo and oskar protein accumulates ectopically and to abnormally high levels. These defects are distinct from previously described perturbations in oskar activity and provide new insights into the regulation of oskar.

Animals↗
PubMed1996

aubergine enhances oskar translation in the Drosophila ovary.

Although translational regulation of maternal mRNA is important for proper development of the Drosophila embryo, few genes involved in this process have been identified. In this report, we describe the role of aubergine in oskar translation. Previously, aubergine has been implicated in dorsoventral patterning, as eggs from aubergine mutant mothers are ventralized and seldom fertilized (Schupbach, T. and Wieschaus, E. (1991) Genetics 129, 1119-1136). We have isolated two new alleles of aubergine in a novel genetic screen and have shown that aubergine is also required for posterior body patterning, as the small fraction of eggs from aubergine- mothers that are fertilized develop into embryos which lack abdominal segmentation. Although aubergine mutations do not appear to affect the stability of either oskar mRNA or protein, the level of oskar protein is significantly reduced in aubergine mutants. Thus, aubergine is required to enhance oskar translation. While aubergine-dependence is conferred upon oskar mRNA by sequences in the oskar 3' UTR, aubergine may influence oskar translation through an interaction with sequences upstream of the oskar 3' UTR.

Animals↗
PubMed1991

Nutritional management of children and adolescents with insulin-dependent diabetes mellitus: a review by the diabetes care and education dietetic practice group.

Although individuals with insulin-dependent diabetes mellitus (IDDM) represent only a small proportion of the total number of persons with diabetes, IDDM is one of the most prevalent chronic childhood diseases. The goals of management in IDDM include normal growth and development, control of blood glucose, maintenance of optimal nutritional status, and prevention of complications. Insulin replacement is the mainstay of treatment in IDDM; however, optimal therapy requires a careful balance of food, insulin, and physical activity. To our knowledge, this is the first comprehensive nutrition review of IDDM that emphasizes research specifically in the area of IDDM (vs non-insulin-dependent diabetes mellitus), including data on children and adolescents when available. the process of nutrition education utilizes a staged approach beginning with "survival" information and progressing to in-depth or continuing education and counseling. Important considerations should be to guide the child/adolescent to a meal plan that fits individual life-style, promotes optimal compliance, and advances the goals of management. Throughout the diabetes nutrition education process, the dietitian can positively affect the lives of children/adolescents and their families. More research is needed to better define ways of meeting the nutrition needs of children and adolescents with IDDM in the areas of fiber and glycemic control, fish oil and lipids, sodium and hypertension, and weight control.

Adolescent↗
PubMed1980

Marry capital giving cycle with deferred giving cycle.

This article suggests a way to transform the future to the present by transferring planned giving techniques into capital campaigning. The author discusses the merits of his case by instilling the needs of the donor first and the success of the institution as a natural second.

Financial Management↗
PubMedDate not supplied

Pizazz in the pediatric population.

Teaching the Exchange Lists for Meal Planning to children with insulin-dependent diabetes mellitus requires a different approach from that used with patients in other stages of the life cycle. To fill your nutrition education sessions with pizazz and capture the childrens' attention, use some of the creative ideas for teaching and utilizing the exchange system presented here.

Adolescent↗