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Biomedical subjects

J E Carter

Publications and source records attributed to J E Carter.

At least 127 records · Page 7Linked to original sources
PubMed1980

Nitroglycerin compatibility with intravenous fluid filters, containers, and administration sets.

The effect of intravenous filters, containers and administration sets on nitroglycerin potency was studied. Solutions of nitroglycerin (50 and 100 microgram/ml) in water for injection, in 5% dextrose injection and in 0.9% sodium chloride injection were prepared. The concentration of these solutions was measured after (1) filtration through a 0.2-micron filter, (2) storage in glass and plastic containers and (3) administration through eight i.v. administration sets. Filters decreased nitroglycerin concentration by 2--55%. Nitroglycerin concentration was not changed after storage for 48 hours in glass bottles. In plastic i.v. bags, concentration decreases were substantial and related to surface contact area and storage temperature. The i.v. administration sets caused immediate, substantial decreases in nitroglycerin concentration that were a function of drip rate, surface area, length of exposure to tubing, and tubing materials. The study suggests that concentrations of nitroglycerin solutions could be reduced by as much as 80% when filtered, placed in a plastic i.v. bag and given through an i.v. administration set.

Drug Packaging↗
PubMed1980

Bretylium tosylate intravenous admixture compatibility. I: Stability in common large-volume parenteral solutions.

The stability of bretylium tosylate in 11 common large-volume parenteral solutions was studied. Two containers of each solution, one glass and one plastic (except for mannitol and sodium bicarbonate solutions, which were available in glass only), were stored at each of the following conditions: intense light (1400-2000 foot candles), ambient room temperature with normal light, 40 degrees C, and 4 degrees C. All samples were tested at 0 and 24 hours; some samples were also tested at 48 hours and 7 days. Testing included measurement for optical density at 4000 and 600 nm, pH level, and bretylium content as determined by HPLC. The admixtures remained clear and colorless, except that mannitol precipitated out of mannitol solutions stored at 4 degrees C. No appreciable changes in pH were observed. HPLC assays showed no significant changes in bretylium tosylate concentrations. Bretylium tosylate is compatible with each of the 11 common intravenous solutions chosen for investigation under the storage conditions studied. Admixtures with mannitol should not be refrigerated, because mannitol crystallizes from solution at refrigerator temperatures.

Bretylium Compounds↗
PubMed1980

Anthropometric characteristics of female Olympic rowers.

Anthropometric data on 51 (23%) of the female rowers in the 1976 Montreal Olympic Games are summarized and compared to a female non-rower athletic sample and to a female Canadian university student sample. The rowers, being taller and heavier (means 174.3 cm and 67.4 kg) tended to be larger in all measures than the reference samples, with the exception that the university students had larger mean skinfold thicknesses. The Heath-Carter somatotype distribution of the rowers (mean 3.1 - 3.9 - 2.8) was compared to that of the students (4.0 - 3.5 - 2.9) and other female athletic samples. Proportionality profiles scaled to a unisex reference human or phantom showed both samples to be rather similar in proportional lengths except for longer tibiale height, wider transverse chest breadth, larger flexed arm and forearm girths, and smaller skinfold thicknesses in female rowers than in students. Fractionation of body mass by a four-component model showed the rowers to have similar percent skeletal and residual masses, lower percent fat and higher percent muscle mass than students. The anthropometric characteristics as described and analyzed in this study are submitted as the basic anthropometric reference for those interested in fostering the development of women's rowing.

Adolescent↗
PubMed1979

Rapid and accurate stability-indicating assay for nitroglycerin.

A rapid high-pressure liquid chromatographic method for determining the nitroglycerin concentration in liquid dosage forms and intravenous admixture solutions is presented. A coefficient of variation of less than 1.8% was achieved over the concentration range most commonly encountered (50-500 microgram/ml). A variable wavelength detector (lambda = 218 nm) and a micro-alkyl phenyl column were employed. The mobile phase was acetonitrile-tetrahydrofuran-water (26:10:64). Total analysis time was 12 min.

Chromatography, High Pressure Liquid↗
PubMed1979

Extrinsic lesions simulating hepatic metastases.

When numerous defects are demonstrated in the liver scan of a patient confirmed as having malignant tumor, metastatic disease of the liver can usually be easily diagnosed. However, the scan must be interpreted with caution because extrinsic tumor compression often mimics metastatic disease.

Diagnosis, Differential↗
PubMed1979

Cardiac ganglionitis associated with sudden unexpected death.

In a postmortem study of the hearts of two young women who died suddenly and unexpectedly, we found a remarkably similar and distinctive ganglionitis, predominantly in the region of the sinus node. Both women had ventricular fibrillation at the time of collapse. Vesicular neuritis and older neural degeneration were present in other regions of the heart. Except for focal fibromuscular dysplasia of the sinus node artery and atrioventricular node artery of one heart, there was no other significant anatomic abnormality in either heart. The functional significance of this cardiac ganglionitis is unclear, but its location in and around the conduction system makes it a possible cause of the fatal electrical instability. Recognition that ganglionitis of the heart may be associated with sudden death should stimulate a number of additionally useful studies.

Adult↗
PubMed1978

Changes in somatotypes of European males between 17 and 24 years.

In order to examine the possible changes in somatotype of young males, 14 boys who had been somatotyped annually from 11 to 18 years by the Health-Carter anthropometric rating method were re-somatotyped at 24 years. The analysis focused on years 17, 18 and 24. Discriminant analysis, somatotype dispersion indices and distances, and the I-index were used to analyze the data. The findings showed a significant shift in somatotype from ectomorphmesomorph towards endo-mesomorphy between 17 and 24 years. This shift was greater than that observed by Zuk ('58), and was in the same direction. It is hypothesized that the somatotypes of males become more endo-mesomorphic from 17 years to the mid-twenties.

Adolescent↗
PubMed1978

Intropin (dopamine hydrochloride) intravenous admixture compatibility, Part 3: stability with miscellaneous additives.

The compatibility of dopamine hydrochloride (Intropin) with various additives in 5% Dextrose Injection, USP, was studied. Dopamine hydrochloride stability for 24 hours in the admixture was established by colorimetric and thin-layer chromatographic procedures. Dopamine hydrochloride solutions are generally stable at an acidic pH and all admixtures produced a slightly acidic solution. Additives tested and found stable for 24 hours in the presence of Intropin included heparin sodium, lidocaine hydrochloride, neutral cephalothin sodium, oxacillin sodium and gentamicin sulfate. The chemical stability of methylprednisolone sodium succinate and hydrocortisone sodium succinate was not established. Potassium chloride, calcium chloride and calcium gluceptate may be assumed to be stable in the presence of Intropin. Above pH 5.0, the calcium gluceptate-Intropin admixture exhibited a color change indicating physical incompatibility. The pH and physical compatibility of all admixtures were established. In order to avoid a fixed combination of potent drugs, it is recommended that a "piggyback" administration set or administration into a second injection site be employed when another drug is to be administered with Intropin.

Dopamine↗
PubMed1977

Synthesis and PMR and mass spectra of potential metabolites and other derivatives of bis(2-ethylhexyl) phthalate.

The 3- and 4-hydroxylated derivatives of the plasticizer bis(2-ethylhexyl) phthalate and the monoesters derived from these hydroxylated derivatives were synthesized. The structures of the two 4-hydroxy monoesters were confirmed by lithium borohydride reduction to their corresponding hydroxymethylbenzoic acids, followed by cyclization of the reduced compounds to known phthalides. All compounds were characterized by PMR and mass spectra. The PMR data reiterate the difficulty in predicting chemical shifts in multisubstituted benzene rings.

Diethylhexyl Phthalate↗
PubMed1976

Influence of physical activity on stability of somatotypes in boys.

The purpose of this study is to examine the stability of somatotypes of boys with different activity levels followed longitudinally for eight years. Thirty-nine boys ated 11 were somatotyped annually (until 18 years) using the Heath-Carter anthropometric rating method. Three sub-groups were formed according to their levels of systematic physical activity designated High, Moderate, and Low Activity. There were no differences in somatochart distributions of the Total Group, but there were considerable individual changes which cancelled each other in group comparisons. All boys changed their somatotype ratings at least once and 67% changed in component dominance. The inter-age correlations for the components were generally of poor prediction value, and the somatotype migratory distances showed considerable variation. The Total Group means differed on three components and this was attributed to differences within the Moderate Activity Group, the only sub-groups to differ. It was concluded that changes occur in somatotypes of adolescent boys, but the influence of physical activity on the changes is inconclusive.

Activities of Daily Living↗
PubMed1976

Intropin (dopamine hydrochloride) intravenous admixture compatibility. Part 2: stability with some commonly used antibiotics in 5% dextrose injection.

The stability of dopamine hydrochloride (Intropin) and several commonly used antibiotics was studied as admixtures in 5% Dextrose Injection USP. The antibiotic-dopamine-dextrose 5% admixtures were assayed for dopamine by colorimetric and chromatographic procedures. The antibiotics were assayed by standard microbiological methods. Kanamycin sulfate, tetracycline hydrochloride, carbenicillin disodium and chloramphenicol sodium succinate were stable in the Intropin-5% dextrose admixture for a period of 24 hours at room temperature in fluorescent and natural (western exposure) light. Gentamicin sulfate, penicillin G potassium and cephalothin sodium were stable in Intropin-5% dextrose admixture for six hours. Ampicillin sodium was stable in the Intropin admixture for only one hour. Amphotericin B was physically unstable in the Intropin-dextrose 5% solution upon admixture. The potency of dopamine hydrochloride remained substantially unchanged in the presence of the above antibiotics. It is recommended that dopamine not be added to amphotericin B or ampicillin sodium admixtures. Further, in order to avoid a fixed combination of potent drugs, it is recommended that a "piggyback" administration set or administration into a second injection site be employed when another drug is to be administered with dopamine hydrochloride.

Anti-Bacterial Agents↗
PubMed1975

Effects of stressful underwater demolition training on body structure.

Antropometric measurements and Heath-Carter somatotype ratings were made on 32 subjects upon entry into a U.S. Navy underwriter demolition team training program. Twenty subjects successfully completed the 4-month program and were remeasured. Comparisons were made between initial and final scores for those completing training, and between initial scores for trainees who successfully completed the program and scores for those men who dropped from training, for the following variables: somatotype as a whole, three somatoptype components, height, weight, height/weight.33, sum of skinfolds, arm and calf girths, and bone breadths. No differences were seen between successful and unsuccessful trainees, on any variable, when results from the pre-training measurements were compared. Successful trainees did not change in height or bone breadths, but showed decreased skinfolds and height/weight.33, along with increased weight and girths. Successful trainees' somatotypes changed, with a decrease in endomorphy and ectomorphy, and an increase in mesomorphy.

Adult↗