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Biomedical subjects

J E Brorsson

Publications and source records attributed to J E Brorsson.

5 recordsLinked to original sources
PubMed1980

Disseminated aspergillosis treated with amphotericin B and surgery in a boy with chronic granulomatous disease.

A case of systemic infection caused by Aspergillus fumigatus in a seven-year-old boy suffering from chronic granulomatous disease is described. The fungus had infiltrated his lungs, his left foot and the popliteal and inguinal lymph nodes. Amphotericin B, 1 mg/kg daily, was given for three months via a central venous catheter, Progressive anaemia made amputation of his left leg necessary. The bone tissue was heavily infiltrated with fungal elements. The regional lymph nodes were also resected because of fungal growth. After six months no fungi were found in liver aspirates taken on account of liver abscesses due to Staphylococcus aureus. The combined medical and surgical approach resulted in complete eradication of the Aspergillus infection, as verified by the disappearance of Aspergillus precipitins.

Amphotericin B↗
PubMed1976

Comparative study of the in vitro antibacterial activity of cefoxitin, cefuroxine, and cephaloridine.

The in vitro antibacterial effects of cefoxitin, a semisynthetic cephamycin, cefuroxime, a new cephalosporin antibiotic, and cephaloridine were compared. With gram-positive bacteria, marked differences were found only in the effects against Streptococcus faecalis, where cephaloridine and cefuroxime were superior to cefoxitin. With gram-negative aerobic bacteria, cefoxitin, which is known to be more resistant to beta-lactamases from gram-negative bacteria than any cephalosporin, was found to be more effective than cefuroxime and cephaloridine against ampicillin-resistant strains of Escherichia coli and indole-positive strains of Proteus. Haemophilus influenzae was found to be more susceptible to cefuroxime than to cefoxitin and cephaloridine. When ampicillin-resistant strains of H. influenzae were tested, markedly higher minimal inhibitory concentration values were obtained with cephaloridine in comparison to those obtained with ampicillin-susceptible strains. These increases in the minimal inhibitory concentration values were not observed with cefoxitin and cefuroxime, probably due to the resistance of these two compounds to beta-lactamases. Strains of Bacteroides fragilis were found to be much more susceptible to cefoxitin than to cefuroxime, which in turn was superior to cephaloridine. The results obtained indicate that cefoxitin and cefuroxime both are superior in their antibacterial spectra to the cephalosporins that are now in clinical use.

Bacteria↗
PubMed1976

Isolation of Chlamydia in acute salpingitis.

In 22 patients with acute salpingitis, verified by laparoscopy, samples for attempted isolation of bacteria, Mycoplasma and Chlamydia were drawn from aspirates and cervical smears. CF-antibodies to Chlamydia were measured to acute and convalescent phase sera. Anaerobic bacteria were isolated from tubal secretions in two patients and Mycoplasmas in one patient. In two patients Chlamydia were recovered from the Fallopian tube. The serological investigation indicated Chlamydia infection in 6 patients.

Acute Disease↗