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Biomedical subjects

J Duprey

Publications and source records attributed to J Duprey.

72 records · Page 4Linked to original sources
PubMedDate not supplied

[Adrenoleukodystrophy (Schilder-Addison's disease): a probable case in an adult (author's transl)].

Adrenoleukodystrophy (Schilder-Addison's disease) is a sex-linked recessive syndrome usually observed in children, associating neurological disorders and Addison's disease. Its outcome is death after a few years. The authors report the case of a man in whom a spastic paraparesis and a mental deterioration appeared at the age of 30 years. A biological adrenal deficiency was found: plasma cortisol and urinary 17-hydroxy-steroids and 17-ketosteroids failed to increase after synacthen stimulation; plasma ACTH level was above normal. Since two nephews of the patient suffered from adrenoleukodystrophy, the same disease is likely in the reported patient.

Addison Disease↗
PubMedDate not supplied

[Tomodensitometry: localizing value in hypertension of adrenal origin (author's transl)].

Computarized axial tomography has shown the localization of adrenal lesions in four cases of hypertension of adrenal origin: two phaeochromocytomas, one primary hyperaldosteronism, one Cushing's syndrome. This method has the advantage of being neither invasive, nor time-consuming. Unfortunately, it cannot localize tumors smaller than two cm in diameter. It seems to be highly beneficial in phaeochromocytoma, where it can advantageously take the place of arteriography. It is less fruitful in primary hyperaldosteronism and in Cushing's syndrome because lesions are smaller.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

[Results of treatment of Graves' disease by antithyroid drugs. Report of 90 cases (author's transl)].

Ninety patients with Graves' disease were given treatment with antithyroid drugs. The first course, which is almost always immediately successful, gave in the long term 46 failures and 44 successes. Among the latter, 38 had a follow up equal or greater than one year after interruption of the course. Among the 78 cases sufficiently well followed up for the whole period of treatment (of which 21 had at least two courses of treatment), we noted 23 failures and 55 successes (70%) for which the average follow up was 61 months. If one requires a follow up equal or greater than one year after the end of treatment, we noted 47 good results out of 70 fully documented cases, i. e. 67%. The possible failures almost always occurred less than one year after the end of treatment. The delay since the last interruption of antithyroid drugs is thus of prognostic value. The result of treatment was not found to be related to any of the clinical or laboratory parameters found during the initial stage of the disease, nor with the type of antithyroid drug used. The addition of thyroid hormone to antithyroid drugs does not seem to be of any use. On the other hand, delay in starting treatment seems to favour the failure of treatment. Other interesting prognostic factors may be sought in the kinetics of TSH, the T3-suppressibility, the early radioiodine uptake, the estimation of thyrostimulating antibodies, and the study of HLA histocompatibility antigens.

Adolescent↗
PubMedDate not supplied

[Adrenomyeloneuropathy in adults. Relationship with adrenoleukodystrophy in children (author's transl)].

The case reported concerns a man in whom appeared gradually, since the age of twenty-seven years, difficulty in walking and sexual impotence. The neurological syndrome consisted of pyramidal signs and objective sensory disorders of the lower limbs, intermittent sphincter disorders and mild mental deterioration, which was progressive. Biopsy of a sensory nerve showed rarefaction of myelinated fibres. The endocrine syndrome consisted of peripheral adrenal insufficiency, which was undoubted but with biologic evidence only. There was no response of plasma cortisol during five stimulation tests with tetracosactide and there was a gradual rise in plasma A.C.T.H. The clinical picture was thus that of an adrenomyeloneuropathy.

Adrenal Insufficiency↗
PubMedDate not supplied

[A phonomecanographic test of hyperthyroidism].

Systolic intervals may be studied by phonomechanography. This provides data regarding the function of the left ventricle. In the absence of any problem of intraventricular conduction or valvular lesion, such information is particularly valuable. Thyroxine impregnation, whetHer active directly and/or by catecholamine hypersecretion, results in cardiac hyperkinesia which is reflected not only by tachycardia but also a shortening penetration time and contraction of the ventricular muscle. This shows itself within systole as a change in the relation between the duration of the pre-ejection phase (PPE) and the ejection phase. The first decreases whilst the second remains normal and their ratio changes, PPE/E changes from a normal value of 0.34 +/- 0.04 to 0.25 +/- 0.03. These tests are not only of value in diagnosis but also make it possible to observe the effects of treatment. It is certain that a true phonomechanographic syndrome of cardiac hyperkinesia may be described. The commonest, though not the only, aetiology is hyperthyroidism.

Electrocardiography↗